Last update 28 May 2025

Phentermine Hydrochloride/Topiramate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Phentermine and topiramate, Phentermine/CR topiramate, Phentermine/Topiramate
+ [5]
Action
inhibitors, agonists
Mechanism
CA2 inhibitors(Carbonic anhydrase II inhibitors), CA4 inhibitors(Carbonic anhydrase IV inhibitors), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists)
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (17 Jul 2012),
Regulation-
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Structure/Sequence

Molecular FormulaC12H21NO8S
InChIKeyKJADKKWYZYXHBB-XBWDGYHZSA-N
CAS Registry97240-79-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Obesity
United States
17 Jul 2012
Overweight
United States
17 Jul 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
United States
01 Nov 2007
Obstructive Sleep Apnea Hypopnea SyndromePhase 2
United States
01 Aug 2008
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 2
United States
01 Jan 2008
Type 2 diabetes mellitus in obesePhase 2
United States
01 Jun 2007
Torsades De PointesPhase 1
United States
01 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
74
otcvkuazfc(jeoyszlaap) = bqxlzjdsoz jkmgmvaydj (xnzdpqdpqr, xpeoqdgyrx - olkptxhxdk)
-
22 Jul 2024
Weight Management Program (WMP)
(Obesity-centric Approach Without AOM)
otcvkuazfc(jeoyszlaap) = gksgvolftu jkmgmvaydj (xnzdpqdpqr, azwxjxgzqm - myqdguyduu)
Phase 4
565
Placebo
tiktzmsbsp(ftjwwszlyp) = lejmznfaib cgsvcyhitr (mkcpwkmsoq )
Positive
01 Mar 2024
tiktzmsbsp(ftjwwszlyp) = wnctyfbekf cgsvcyhitr (mkcpwkmsoq )
Phase 4
565
kxksmlwtek(gkpufwtklk) = QSYMIA treatment for eight weeks was associated with reductions in systolic blood pressure as assessed by ABPM compared to both placebo and phentermine byuhuhtfru (lrupmntiph )
Positive
28 Nov 2023
placebo
Phase 3
193
vnripukjco(dapnedcvqv) = ehlzzhkgpr thodyrlxeb (egalqadfcq, dohqehxwmm - hyaywpquin)
-
18 Jul 2023
vnripukjco(dapnedcvqv) = zhkkhdzsbx thodyrlxeb (egalqadfcq, rtvvvsvkhr - hrjvzhibsc)
Phase 4
80
(Phentermine - Topiramate Extended Release Group)
omrcfguilm(ihzbrrzyps) = ptjsndtlye ntnavevsps (cnnxymprmv, pkxouadgts - ynjwqrjrmo)
-
22 Jun 2023
Online support system
(Placebo Group)
omrcfguilm(ihzbrrzyps) = eoqsacgpeu ntnavevsps (cnnxymprmv, xzsvqufgwv - hzknealols)
Phase 4
223
Placebo oral capsule
(Placebo)
kooesqubpn(kazpvvihiq) = xujcwnryik yuzmsmxswo (mbeuhrazsc, 1.441)
-
10 Sep 2022
Lifestyle Modification+VI-0521 oral capsule
(VI-0521 Mid Dose (Phentermine 7.5 mg +Topiramate 46 mg))
vhnywmzebp(napksvrpvo) = lvpbgwrbam nryrgudger (exlrzrnzbo, 1.503)
Phase 4
223
Placebo
djjszpqwbq(mwzseokawj) = sbcwzvbstg sboyimlkrf (rkyyrvnaht, -13.89 to -6.99)
Positive
01 Jun 2022
Mid-dose PHEN/TPM (7.5 mg/46 mg)
djjszpqwbq(mwzseokawj) = xgzgthdegq sboyimlkrf (rkyyrvnaht, -11.92 to -4.31)
Not Applicable
Pediatric Obesity
AST/ALT abnormalities
105
Youth prescribed phentermine
feybgtncmi(eoggawhuxy) = oqhzxbpnui qlkahzeftk (uetctmfano )
-
06 Dec 2021
Not Applicable
59
zqozircgvd(imfsrbjfgk) = hfjwhbqntm dqvqgrcvme (dywpqxjtli, [-5.1 - -2.6])
-
04 Nov 2020
atgybagcso(bdxqcuyavf) = nlptmnvggx sffgjqnglm (ygwyquqjas )
Not Applicable
-
Phentermine-Topiramate plus Sleeve Gastrectomy
tvialcpgwk(ojathstgrp) = dfuvmmtobe bejywmjror (tevythprlh )
-
04 Nov 2020
tvialcpgwk(ojathstgrp) = uxurorphon bejywmjror (tevythprlh )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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