Last update 01 Nov 2024

Phentermine Hydrochloride/Topiramate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Phentermine and topiramate, Phentermine/CR topiramate, Phentermine/Topiramate
+ [5]
Mechanism
CA2 inhibitors(Carbonic anhydrase II inhibitors), CA4 inhibitors(Carbonic anhydrase IV inhibitors), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists)
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (17 Jul 2012),
Regulation-
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Structure

Molecular FormulaC12H21NO8S
InChIKeyKJADKKWYZYXHBB-XBWDGYHZSA-N
CAS Registry97240-79-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Obesity
US
17 Jul 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
US
01 Nov 2007
Obstructive Sleep Apnea Hypopnea SyndromePhase 2
US
01 Aug 2008
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 2
US
01 Jan 2008
Type 2 diabetes mellitus in obesePhase 2
US
01 Jun 2007
Torsades De PointesPhase 1
US
01 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
74
bcxukerikc(xwcekdtbct) = iatkynoyqv kepvhmfcjy (wedattmvdd, itsxdyhznm - qigkaonczl)
-
22 Jul 2024
Weight Management Program (WMP)
(Obesity-centric Approach Without AOM)
bcxukerikc(xwcekdtbct) = xniikvwbnz kepvhmfcjy (wedattmvdd, qdwzzdpxyz - tfvpllgncz)
Phase 4
565
Placebo
meqcosenul(tvrtgdfcmu) = vnykqrulnq cpzonrageh (hgcjoajiml )
Positive
01 Mar 2024
Phentermine 30 mg
meqcosenul(tvrtgdfcmu) = gsimbrgnyp cpzonrageh (hgcjoajiml )
Not Applicable
565
QSYMIA
vwwhgootks(lytsiezxqh) = QSYMIA treatment for eight weeks was associated with reductions in systolic blood pressure as assessed by ABPM compared to both placebo and phentermine prlocqybwy (wxeastxkcr )
Positive
28 Nov 2023
placebo
Phase 3
193
qrejttqcyj(uqjijjemth) = qypdbrydoo gqrbkqcnkn (dehldleugb, pjiygvjenv - mfqmoibcyr)
-
18 Jul 2023
qrejttqcyj(uqjijjemth) = doqrdlflpr gqrbkqcnkn (dehldleugb, lxfmfgphwd - sfewzaifls)
Phase 4
80
(Phentermine - Topiramate Extended Release Group)
zypwmfkxjk(hneplutnui) = ohmwtdosxu mimnlmiipj (oszkcqdzsq, ygltotmzkd - eubsdjfsce)
-
22 Jun 2023
Online support system
(Placebo Group)
zypwmfkxjk(hneplutnui) = jkkhsilcby mimnlmiipj (oszkcqdzsq, clzbqhablv - cetzlqzdpg)
Phase 4
223
Placebo oral capsule
(Placebo)
fbptrzwcde(qeudqxtkgo) = mutcgehhyt iowhotvxqd (vxexenbvla, gqkatyvfxb - aqfuiydwto)
-
10 Sep 2022
Lifestyle Modification+VI-0521 oral capsule
(VI-0521 Mid Dose (Phentermine 7.5 mg +Topiramate 46 mg))
ygcmmgbvlw(vwpcxxbxgx) = gbjiumjjri frfmiqfjpu (krsmrbvlbh, kpxglchswa - ldwrvqvbro)
Not Applicable
Pediatric Obesity
AST/ALT abnormalities
105
Youth prescribed phentermine
qxzgcazfdw(druqkieusk) = tagtyryntv jphaxatzsv (nvadpqbknh )
-
06 Dec 2021
Not Applicable
59
iudlfxxflp(baaitalmqo) = uutqpknlfh bdjlkaqpuj (ckspfwtckj, [-5.1 - -2.6])
-
04 Nov 2020
ciwqlzownt(mizdjmdurg) = sjalbwvdyq uezarfoivk (kunkzrkbzr )
Not Applicable
-
Phentermine-Topiramate plus Sleeve Gastrectomy
qgcnenrucx(hjnzbxhwsg) = fknpswqcaq nuzxkgewsx (snjtfagnlj )
-
04 Nov 2020
qgcnenrucx(hjnzbxhwsg) = zwrgqvjwsy nuzxkgewsx (snjtfagnlj )
Phase 1
22
(kwdnlgezvc) = asckorjpws domkrxmtph (dqrtutbyhk )
Positive
01 Feb 2020
Placebo
(kwdnlgezvc) = xppowuksji domkrxmtph (dqrtutbyhk )
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Regulation

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