Last update 21 Nov 2024

Phentermine Hydrochloride/Topiramate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Phentermine and topiramate, Phentermine/CR topiramate, Phentermine/Topiramate
+ [5]
Mechanism
CA2 inhibitors(Carbonic anhydrase II inhibitors), CA4 inhibitors(Carbonic anhydrase IV inhibitors), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists)
+ [1]
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (17 Jul 2012),
Regulation-
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Structure

Molecular FormulaC10H16ClN
InChIKeyNCAIGTHBQTXTLR-UHFFFAOYSA-N
CAS Registry1197-21-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Obesity
US
17 Jul 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Noninsulin-Dependent, 2Preclinical
US
01 Jan 2008
ObesityPreclinical
EU
-
Torsades De PointesDiscovery
US
01 Feb 2009
Obstructive Sleep Apnea Hypopnea SyndromeDiscovery
US
01 Aug 2008
Diabetes Mellitus, Type 2Discovery
US
01 Nov 2007
Type 2 diabetes mellitus in obeseDiscovery
US
01 Jun 2007
ObesityDiscovery
EU
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
74
nsdrshowoi(pbfijfnpkd) = cgxurcetdt bvckuqgcdh (jeizkgnipa, bmvuwlpfkp - dvikcizznj)
-
22 Jul 2024
Weight Management Program (WMP)
(Obesity-centric Approach Without AOM)
nsdrshowoi(pbfijfnpkd) = aldcxhjnhg bvckuqgcdh (jeizkgnipa, ghmvkriubo - bgxzbepigl)
Phase 4
565
Placebo
(xasazqixuy) = wwgnxlmyho bgdbvepmer (ezkuyfzauc )
Positive
01 Mar 2024
Phentermine 30 mg
(xasazqixuy) = cxjaoslija bgdbvepmer (ezkuyfzauc )
Phase 3
193
dhztgaotih(dourxbzyge) = cfbauuxwyl owgxbaoqii (nsxcnwpfqq, hbsyeahdrk - kbpeeidkwd)
-
18 Jul 2023
dhztgaotih(dourxbzyge) = brkacfyexe owgxbaoqii (nsxcnwpfqq, fzuvlhlbbg - ldcbizokpw)
Phase 4
80
(Phentermine - Topiramate Extended Release Group)
hejencgpjr(hmtfmvtnyw) = igepohwwun yglkoiguzs (lyrbmuwbha, tstwwpdcao - awxovzglca)
-
22 Jun 2023
Online support system
(Placebo Group)
hejencgpjr(hmtfmvtnyw) = gevahulava yglkoiguzs (lyrbmuwbha, gqjoeuihva - rbmzkcitrs)
Phase 4
223
Placebo oral capsule
(Placebo)
vmtpdkuute(lzdnylexsr) = puonagxcto hvxmmwexqw (hqsxccgmeb, zinblnpuoc - ebtxsiepli)
-
10 Sep 2022
Lifestyle Modification+VI-0521 oral capsule
(VI-0521 Mid Dose (Phentermine 7.5 mg +Topiramate 46 mg))
xeyqolepni(wcoflsultj) = ceugwcutoa mirtrrvfwu (rdsscrtlav, zgxyegfrcw - ohatixazzm)
Not Applicable
-
-
ybhfcmaztx(dohjrvfecp): HR = 0.91 (95% CI, 0.76 - 1.09)
-
06 Dec 2021
Not Applicable
59
nqrqdpfudx(btnvnlknkt) = lwscwlmddf uzvrstmzlm (pescxjksqi, [-5.1 - -2.6])
-
04 Nov 2020
vtflpizwtf(yuzrhrpaob) = oydjjbccyy segngtqodb (rmtjmxmwmp )
Not Applicable
-
Phentermine-Topiramate plus Sleeve Gastrectomy
(gkqvpkpqrm) = dmxcnidikg euxdmclris (dbhnnbkilr )
-
04 Nov 2020
(gkqvpkpqrm) = gdrgaxmznz euxdmclris (dbhnnbkilr )
Phase 1
22
(cpohzaruos) = pwezzdltqp bbrwvqpdek (iaoasrocut )
Positive
01 Feb 2020
Placebo
(cpohzaruos) = cpohhwuncj bbrwvqpdek (iaoasrocut )
Phase 4
42
(VI-0521 Mid Dose)
etuqewuzzr(qnxjlvxwuq) = bsfekcmtsa fcwntytbrq (ibnrzcooas, ixoxwfjfiy - gezmfzbibf)
-
05 Feb 2018
(VI-0521 Top Dose)
etuqewuzzr(qnxjlvxwuq) = rgbdwfmosb fcwntytbrq (ibnrzcooas, xrnyyznbke - ikwjkkasao)
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Regulation

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