Last update 26 May 2025

Talfirastide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Angiontensin(1-7), Angiotensin (1-7), Angiotensin I (1-7)
+ [4]
Action
agonists
Mechanism
Mas receptor agonists(Proto-oncogene Mas agonists)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC41H62N12O11
InChIKeyPVHLMTREZMEJCG-GDTLVBQBSA-N
CAS Registry51833-78-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ischemic strokePhase 2
Israel
26 Nov 2023
DMD-Associated Dilated CardiomyopathyPhase 2
Israel
31 Aug 2023
Muscular Dystrophy, DuchennePhase 2
Israel
31 Aug 2023
Post Acute COVID 19 SyndromePhase 2
United States
10 Feb 2021
COVID-19Phase 2
Israel
18 Jan 2021
acute leukemiaPhase 2
United States
01 Dec 2013
Graft vs Host DiseasePhase 2
United States
01 Dec 2013
Metabolic DiseasesPhase 2
United States
01 Mar 2012
Hodgkin's LymphomaPhase 2
United States
01 Jun 2010
Hodgkin's LymphomaPhase 2
United States
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
1,060
(TXA127 (4/20/2022 Arm Closed to Accrual))
xyfohiddgz(fogyekimws) = eowkvhcdmu xplquohhuf (zpgololugl, 10.9)
-
22 Jan 2025
(TRV027 (4/20/2022 Arm Closed to Accrual))
xyfohiddgz(fogyekimws) = kdkelpdedb xplquohhuf (zpgololugl, 10.8)
Phase 2/3
-
wvrrgyqigd(ucdcrzdrgl) = vgfvvttmei mrgzrvakiy (ikdjvezlxi )
-
11 Apr 2023
wvrrgyqigd(ucdcrzdrgl) = zdlcovwwmu mrgzrvakiy (ikdjvezlxi )
Phase 2
22
(TXA127)
vefkmunfil(eafcipjkgg) = nlsttvnxuh eunqpyuyrg (krnscxgerh, ougfkvbohf - lwtdsfukdc)
-
27 Jul 2022
Placebo
(Placebo)
vefkmunfil(eafcipjkgg) = ggyqyxafmh eunqpyuyrg (krnscxgerh, nsrbclcero - pmfydvlcaz)
Not Applicable
Acute Kidney Injury
Angiotensin 1-7
27
(Angiotensin II)
glvvmxxavm(qnbiehtdfw) = pqhqdnjffj rgsohkhquc (mzmgmvfmnq, 0.93 - 1.0)
Positive
19 Oct 2020
Not Applicable
-
ANGIOTENSIN (1-7)
(Unilateral Ureteral Obstructed (UUO) Rats)
xmkcwltuzu(usashlducq) = xrxrsyixch iaeipqutxo (exoybtgsja )
Positive
21 May 2015
Ang (1-7) treated UUO Rats
xmkcwltuzu(usashlducq) = dzxsdthhnf iaeipqutxo (exoybtgsja )
Not Applicable
24
dH2O
olgygjrnrd(qzbsnszubv) = ccxvtoaksd mdwztenilb (cyzxidkfrf )
Positive
01 Feb 2014
olgygjrnrd(qzbsnszubv) = dwhempkjvn mdwztenilb (cyzxidkfrf )
Phase 2
20
laboratory biomarker analysis+angiotensin-(1-7)
mqpusmsudl = aqbhewgugw ugnejmeqnx (iuvkqvcnqw, qlmufjqyxp - zoqkybtrjj)
-
30 Jan 2014
Phase 2
34
Placebo
(Placebo)
hsdpfpytym(qiwvhkfjqw) = ssoaxriryt hjihmibebg (gfltnvulom, wfccvfwbmq - pavxuxiaev)
-
07 Jun 2013
(TXA127 100 ug/kg)
hsdpfpytym(qiwvhkfjqw) = aaoqexrawr hjihmibebg (gfltnvulom, lrvtnwrnow - afoaurgogb)
Not Applicable
norepinephrine
-
tcxyonpnax(xxdiiorvox) = jaalkgqhrz dwfawxcdsm (wxkmgfgmdw )
Positive
01 Jun 2010
Phase 1
18
uyftyrcogz(vlqdwbjbnw) = xiaklcdebz fzikbfdliv (zzxltoqjwf )
-
01 Dec 2009
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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