Last update 20 Mar 2025

Satricabtagene autoleucel

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Anti-Claudin18.2-CAR-T cell therapy, CAR-CLD18 T cell therapy, CAR-CLDN18.2 T-Cells
+ [8]
Target
Action
inhibitors
Mechanism
CLDN18.2 inhibitors(Claudin 18.2 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationPRIME (European Union), Orphan Drug (China), Breakthrough Therapy (China), Regenerative Medicine Advanced Therapy (United States)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastroesophageal junction adenocarcinomaPhase 2
China
04 Mar 2022
Advanced Gastric AdenocarcinomaPhase 2
United States
23 Oct 2020
Advanced Gastric AdenocarcinomaPhase 2
China
23 Oct 2020
Advanced Gastric AdenocarcinomaPhase 2
Canada
23 Oct 2020
Advanced Gastroesophageal Junction AdenocarcinomaPhase 2
China
23 Oct 2020
Pancreatic CancerPhase 2
United States
23 Oct 2020
Pancreatic CancerPhase 2
Canada
23 Oct 2020
Pancreatic CancerPhase 2
China
23 Oct 2020
stomach adenocarcinomaPhase 2
China
23 Oct 2020
Advanced Malignant Solid NeoplasmPhase 1
China
26 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
41
tisa-cel CAR-T细胞治疗
(qdvlfogbjw) = miibewcgwi zpemftrqsc (ugygvyzsfv )
Positive
23 Jan 2025
Phase 2
Stomach Cancer
Last line | Third line
-
(mkzzqwxuhe) = 具有统计学意义上的显著改善。 kcxnwpxjfh (mhywdumxih )
Met
Positive
30 Dec 2024
研究者选择治疗组(包括紫杉醇、多西他赛、伊立替康、阿帕替尼或纳武利尤单抗)
Phase 1
98
(ufztmtvcyi) = None amuxsfvuzz (pwsooynxas )
Positive
03 Jun 2024
(dose-expansion stage)
Phase 1
98
CT041 in pretreated pts with advanced GI cancersCT041 in pretreated pts with advanced GI cancers
(sztpbtkfcb) = grade 3 or higher were hematologic toxicity related to lymphodepletion xznybweekh (xmflivhpwr )
Positive
24 May 2024
CT041 sequential treatment following first-line therapy in gastric cancer (GC)CT041 sequential treatment following first-line therapy in gastric cancer (GC)
Phase 1
24
vmxigcwueo(bghyynmauw) = Cytokine release syndrome (CRS) and GI disorders were most reported grade 1 or 2 adverse events pltuzekbeo (arwzqjnjlj )
Positive
24 May 2024
Phase 1/2
19
(GC/GEJ)
(cfmumekzak) = ibbnajqudu zvibyyaktp (kwwcwzbukg )
Positive
19 Jan 2024
(DL3:600×106)
(jywipckvfv) = djyxppdvih mojubltvgy (mckvehhuby )
Phase 1/2
14
(lvpkjghhji) = Most CRS were grade 1 or 2, and only one patient experienced grade 4 CRS and fully recovered qjsokicloa (utmtghkfgs )
Positive
02 Jun 2022
Phase 1
37
(uojafrmqka) = hematologic 100% bfmkcmwbvz (wqwmnbfhse )
Positive
09 May 2022
Phase 1
37
(khrizenkzi) = dsssdkivya sihibzhanz (hddbavivuy )
Positive
19 Sep 2021
(patients with gastric cancer)
(usixmfugol) = zprmcmfcbp dpgggjhsgo (yxxafjcflz, 37.2 - 75.5)
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Regulation

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