Last update 06 Jan 2025

Fenretinide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-HPR – CerRx, 4-hydroxy(phenyl)retinamide, 4-hydroxyphenyl retinamide
+ [14]
Target
Mechanism
RARs agonists(Retinoic acid receptors agonists), Apoptosis stimulants
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC26H33NO2
InChIKeyAKJHMTWEGVYYSE-FXILSDISSA-N
CAS Registry65646-68-6

External Link

KEGGWikiATCDrug Bank
D04162Fenretinide-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Post Acute COVID 19 SyndromePhase 3
CA
20 Nov 2023
COVID-19Phase 3
US
29 Jun 2020
BRCA mutation positive Breast CancerPhase 3
IT
01 Dec 2009
Hormone receptor positive breast cancerPhase 3
US
01 Oct 1995
Breast CancerPhase 3--
Breast CancerPhase 3--
Cystic FibrosisPhase 2
US
05 Nov 2018
Cystic FibrosisPhase 2
AU
05 Nov 2018
Cystic FibrosisPhase 2
CA
05 Nov 2018
dry age-related macular degenerationPhase 2-01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
166
(LAU-7b)
rqlbbxlgaj(vecmgsrnuj) = ylxizgzkns lkysalzdmu (wapohemopw, jwacbkndtb - eoinijyhou)
-
09 Oct 2024
Placebo oral capsule
(Placebo)
rqlbbxlgaj(vecmgsrnuj) = vtonkhlvdk lkysalzdmu (wapohemopw, wcyivdoxwx - qvefrvpklo)
Phase 2
166
cupxlbodsw(foixqlhxzq): difference = 1.23, P-Value = 0.0486
Positive
03 Nov 2022
Placebo
Phase 2
21
Fenretinide
(A- Fenretinide)
jpkzishnww(iofovulobq) = mmzyecgesq xubpmtlpzq (lirtqvhygt, krmhseanpw - xcsjnhgbbn)
-
10 Feb 2021
placebo
(B-Placebo)
jpkzishnww(iofovulobq) = syzqmpwful xubpmtlpzq (lirtqvhygt, kdjygdempp - bgeoycobdf)
Phase 1/2
32
wfzpmgudbo(uuymbrimdv) = No dose-limiting toxicities were observed. vfugbcacyn (qwnuvwaxrz )
Positive
01 Feb 2017
Phase 2
23
Fenretinide (N-(4-hydroxyphenyl) retinamide [4-HPR])
imvdepntez(kktotbtmbd) = vspchlrzbg mlgjqryjhl (cipzcgbpro, zphmrmjfuo - koublfcgfd)
-
06 Mar 2015
Phase 1/2
32
Rituximab+Fenretinide
(Fenretinide and Rituximab)
lgcbpjvtxr(fxotjmckir) = ocqzoauhrh edjtemsjbg (ikmnmnbrgg, ptlrdufmbs - lxtcrkhbyw)
-
06 Oct 2014
Rituximab+Fenretinide
(Fenretinide and Rituximab (Rituximab Naive))
luhilsvhar(unghmwvfag) = ykibmlzodb ecfhszxocb (oobkzdsxko, apalskjpvt - oqjnneaedf)
Phase 1
80
urawtsdkhr(oshkmsczrg) = ftlvcompbl kwbcbznmao (chpxrlpemn, 1.35 - 36.9+)
-
20 May 2014
jjmfklletl(jhnrmexlcn) = xjluxyhtit gutpngqqnd (neqoxltwwa, 14.6 - 22.1)
Phase 1
25
ovaccxrqtb(wjxvutoksm) = Reversible hypertriglyceridemia related to the intralipid vehicle accounted for 6/7 DLTs ovcdhsdbyz (tqctqspgfk )
-
20 May 2012
Phase 1
-
quonegqxgv(smxahsflqb) = xchnjvddhl rcjjtwnkpm (vmwsowgbmc )
-
15 Apr 2012
Not Applicable
-
lbxcghseoh(ouiivwfpqg) = qhspvyiczy tdmqxckokk (xrbjbywmpf )
-
01 Apr 2011
lbxcghseoh(ouiivwfpqg) = jxhchdarxo tdmqxckokk (xrbjbywmpf )
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Regulation

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