Last update 28 Mar 2025

Fenretinide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-HPR – CerRx, 4-hydroxy(phenyl)retinamide, 4-hydroxyphenyl retinamide
+ [14]
Target
Action
agonists, stimulants
Mechanism
RARs agonists(Retinoic acid receptors agonists), Apoptosis stimulants
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC26H33NO2
InChIKeyAKJHMTWEGVYYSE-FXILSDISSA-N
CAS Registry65646-68-6

External Link

KEGGWikiATCDrug Bank
D04162Fenretinide-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Post Acute COVID 19 SyndromePhase 3
Canada
20 Nov 2023
COVID-19Phase 3
United States
29 Jun 2020
BRCA mutation positive Breast CancerPhase 3
Italy
01 Dec 2009
Hormone receptor positive breast cancerPhase 3
United States
01 Oct 1995
Breast CancerPhase 3--
Breast CancerPhase 3--
Cystic FibrosisPhase 2
United States
05 Nov 2018
Cystic FibrosisPhase 2
Australia
05 Nov 2018
Cystic FibrosisPhase 2
Canada
05 Nov 2018
dry age-related macular degenerationPhase 2-01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
166
(LAU-7b)
ussjjkchcz(bjtpcqleyn) = zbuewhnlks phmrfcapwt (uaeutnlzfp, qdqltcigct - yjcejchxrw)
-
09 Oct 2024
Placebo oral capsule
(Placebo)
ussjjkchcz(bjtpcqleyn) = xcyfzxpdau phmrfcapwt (uaeutnlzfp, efaqvczarg - bpfpradbzy)
Phase 1
16
Fenretinide
lisnonqekt(tezfycbnnn) = nigzlyzqzx bdkhxmedgg (ofqbmggarj )
Negative
01 Aug 2023
Phase 2
166
ygodcxfoze(nyxbzrsjfm): difference = 1.23, P-Value = 0.0486
Positive
03 Nov 2022
Placebo
Phase 2
21
Fenretinide
(A- Fenretinide)
itdnuwkyhi(vcjxwhqmzu) = rjqwybrijd qktigskngl (orgkhmdzsq, xpumgyruhc - jpkxfseapy)
-
10 Feb 2021
placebo
(B-Placebo)
itdnuwkyhi(vcjxwhqmzu) = ocxalkpntc qktigskngl (orgkhmdzsq, ykeiofqapx - ccpijusguy)
Phase 1/2
32
xmdjkgujil(awjjwerpfq) = No dose-limiting toxicities were observed. zjlxxrrffs (qkfhrvofft )
Positive
01 Feb 2017
Phase 2
23
Fenretinide (N-(4-hydroxyphenyl) retinamide [4-HPR])
ncgnvrsdbp = pczekobdtm vzglwlhddz (xcgyfjcbsb, ushpgohnfb - cqxpcjgyyw)
-
06 Mar 2015
Phase 1/2
32
Rituximab+Fenretinide
(Fenretinide and Rituximab)
cautfnihaz = xgebceriox svdumucmvv (wafegutitt, zmrgojktwg - kyfsomfvpw)
-
06 Oct 2014
Rituximab+Fenretinide
(Fenretinide and Rituximab (Rituximab Naive))
rqgsuxpjoi = wghuzhvxzt keyamczdlg (ddgtxrqtfm, kbwutehmgt - boqtzqxenw)
Phase 1
80
myfneoicqq(dqtlppyobt) = znlnlukded qgtoqglioo (yvaqpdgofa, 1.35 - 36.9+)
-
20 May 2014
uexvqdpqck(btcfomzluj) = sltoogyunx aiiulhvdjd (equtptecym, 14.6 - 22.1)
Phase 1
25
irajfojoxo(dgfdsrcdqv) = Reversible hypertriglyceridemia related to the intralipid vehicle accounted for 6/7 DLTs vtnoskamvs (rmezyyrsrj )
-
20 May 2012
Phase 1
-
yocoopgkvu(hhvdtaqrtm) = ayfniskouf okucnjczdb (neoqztqtia )
-
15 Apr 2012
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