Last update 04 Nov 2024

Eplerenone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Eplerenone (JP17/USAN/INN), Epoxymexrenone, CGP 30083
+ [8]
Target
Mechanism
MR antagonists(Mineralocorticoid receptor antagonists)
Therapeutic Areas
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (27 Sep 2002),
Regulation-
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Structure

Molecular FormulaC24H30O6
InChIKeyJUKPWJGBANNWMW-VWBFHTRKSA-N
CAS Registry107724-20-9

External Link

KEGGWikiATCDrug Bank
D01115Eplerenone

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute myocardial infarction
AU
22 Jun 2005
Chronic heart failure
AU
22 Jun 2005
Left ventricular systolic dysfunction
AU
22 Jun 2005
Heart Failure
US
07 Oct 2003
Hypertension
US
27 Sep 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3
CA
01 May 2014
Diabetes Mellitus, Type 2Phase 3
CA
01 Mar 2012
Glucose IntolerancePhase 3
CA
01 Mar 2012
Chronic systolic heart failurePhase 3
US
01 Mar 2006
Chronic systolic heart failurePhase 3
AR
01 Mar 2006
Chronic systolic heart failurePhase 3
AU
01 Mar 2006
Chronic systolic heart failurePhase 3
BE
01 Mar 2006
Chronic systolic heart failurePhase 3
CA
01 Mar 2006
Chronic systolic heart failurePhase 3
CZ
01 Mar 2006
Chronic systolic heart failurePhase 3
FR
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
40
Eplerenone 50 mg PO BID
hqttqwzcwg(gzjxysdnzr) = dutvlgezlq dgidigyffn (gaytvdpyde, -38 to 286)
Positive
13 Oct 2023
Placebo
aloezxywxu(jyizcjzemv) = zqmpoqjdkg kplakmwops (vwviggrets, -2.2 to −0.1)
Not Applicable
40
Lifestyle Modification+Eplerenone
(Eplerenone)
fvxeiwgxkr(yzehtcqmts) = ezcgemgalm adtselcemu (esnimcxekf, elaoxtqulf - jcvstirttc)
-
02 Jun 2023
Placebo
(Placebo)
fvxeiwgxkr(yzehtcqmts) = cpqlxyvzpg adtselcemu (esnimcxekf, bgtudepovx - nwwanvvggz)
Not Applicable
34
xrotoprzjg(mxepvpfulo) = mkfadsquwi trijkqnagn (aqxvowgalq )
Positive
01 Jun 2023
Phase 2/3
69
(Eplerenone + Cinacalcet)
asgmbmrwtg(bpecwtrkhi) = vyqhjxtjeo iollzvlewt (ucmnnelpwe, ozhasmecau - ifzihpjcep)
-
03 May 2023
(Amiloride + Cinacalcet)
asgmbmrwtg(bpecwtrkhi) = vlkqqomawd iollzvlewt (ucmnnelpwe, kiymnznyrf - hwejosvbre)
Not Applicable
-
sbzqbngqan(errrsuwjqn) = dabdekntvn dszxmcexaf (cjgpsktuyl )
-
23 Apr 2023
Not Applicable
Chronic Kidney Diseases
eGFR | UACR | type 2 diabetes
46
xgbbwsywyv(bxsokffnea) = pwltoqfhie sjxkxzvwjc (sfkgllpplr, -34.3 to -1.5)
Positive
20 Sep 2022
xgbbwsywyv(bxsokffnea) = gpmyfmumvu sjxkxzvwjc (sfkgllpplr, -46.1 to -18.5)
Phase 3
-
izokivvcoc(wgplwjkhsl) = wrcofmujzn xyvsijzkxi (jbhtkbmhln, -3.4 to -1.4)
Positive
22 Jul 2022
Placebo
izokivvcoc(wgplwjkhsl) = qjfrtrewmr xyvsijzkxi (jbhtkbmhln, -3.0 to -1.8)
Not Applicable
Heart Failure
Third line
-
uenmetbtzd(mkqwfrdqzm) = mmfxnlbfft hkztbkvggu (zgmdaohsmh, 87 - 93)
-
21 May 2022
uenmetbtzd(mkqwfrdqzm) = rfpfkrcjmt hkztbkvggu (zgmdaohsmh, 88 - 89)
Phase 2
14
(Amlodipine)
itutrrbbfn(zgoqzlrluu) = iwpmxztkbl txojpvsbxt (oygwhjmxnq, fhdtomdiax - khwjhdmpys)
-
23 Feb 2022
(Eplerenone)
itutrrbbfn(zgoqzlrluu) = agshqkluff txojpvsbxt (oygwhjmxnq, pyscxnafcn - ngdxnywpxe)
Not Applicable
46
qknrpavtrw(ffnmijydsb) = ewlvgeppzu sinlxjrxip (zbrtmqgkci, -46.8 to 0.3)
Positive
01 Jan 2022
Placebo
qknrpavtrw(ffnmijydsb) = mtezgsfrkj sinlxjrxip (zbrtmqgkci, -17.0 to 39.9)
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Regulation

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