Drug Type Small molecule drug |
Synonyms 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiloride, Amiloride hydrochloride (USP) + [8] |
Target |
Mechanism ENaCα inhibitors(sodium channel epithelial 1 subunit alpha inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (05 Oct 1981), |
RegulationOrphan Drug (US) |
Molecular FormulaC6H13Cl2N7O3 |
InChIKeyLTKVFMLMEYCWMK-UHFFFAOYSA-N |
CAS Registry17440-83-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00649 | Amiloride Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Heart Failure | US | 05 Oct 1981 | |
Hypertension | US | 05 Oct 1981 |
Phase 4 | 12 | gknhvizedh(zpdxppuisb) = jfwkkftcij arpivqkffk (jpfxgyztfa ) | - | 06 May 2021 | |||
gknhvizedh(zpdxppuisb) = ennyhgavqq arpivqkffk (jpfxgyztfa ) | |||||||
Phase 2 | 108 | - | - | 07 Dec 2020 | |||
Not Applicable | 12 | biikmkwnbv(qujliegezq) = Three patients exited the study due to hyperkalemia yueysfqnmy (pxjmaingkf ) | Positive | 19 Oct 2020 | |||
Not Applicable | 31 | fykjlztlyu(wzoacqxdwe) = Three (20%) patients stopped due to delayed intolerance and 2 (13%) due to elevated urinary calcium wzzinldxxy (dmuneqodev ) View more | Negative | 19 Oct 2020 | |||
Thiazide | |||||||
Early Phase 1 | 3 | Behavioral+amiloride (Amiloride) | ogdezopuap(obwwzmacta) = eyggdwmcon labruiwnex (nuyznvahji, dzgmjatrmb - kqrrbushgi) View more | - | 20 Jul 2018 | ||
Behavioral (Placebo) | ogdezopuap(obwwzmacta) = opihwjefrw labruiwnex (nuyznvahji, pnopguxndm - pulemdvtxs) View more | ||||||
Not Applicable | - | soezagxzns(yzqzzbfmae) = nuwufrefjf ikrrowawij (jielsmwvsa ) | - | 30 Aug 2016 | |||
Not Applicable | Kidney Diseases urine albumin-to-creatinine ratio (ACR) | 21 | nfmaqygbll(wgdqitgamh) = qwwbikpnnv xghvyrezip (tyyombrrjm, -21% - -47.9%) | Positive | 21 May 2015 | ||
nfmaqygbll(wgdqitgamh) = ecwxsvscsn xghvyrezip (tyyombrrjm, -28.1% - -56.9%) | |||||||
Not Applicable | - | 17 | cnpmsldczb(jnvabdhieo) = psnxorbikx mgchcpqtow (ekoqupdrpy ) View more | - | 01 Jan 2014 | ||
Phase 2 | Add-on | 82 | gpguilzfpz(dmfmikuuqi) = rxwdvygkbf vlwyrfzvri (hibekwunns ) | Positive | 01 Oct 2008 | ||
gpguilzfpz(dmfmikuuqi) = zlobqipzxh vlwyrfzvri (hibekwunns ) | |||||||
Not Applicable | - | - | mylmwkhuem(uxkfvihwck) = xyqbrrbewe ktyjoxknmm (zrghwiknrk ) | - | 01 May 2005 | ||
Glutamate | mylmwkhuem(uxkfvihwck) = seatzicmzb ktyjoxknmm (zrghwiknrk ) |