Last update 01 Nov 2024

Omecamtiv Mecarbil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Omecamtiv mecarbil (USAN/INN), AMG-423, CK-1827452
+ [2]
Mechanism
Cardiac myosin stimulants
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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Structure

Molecular FormulaC20H24FN5O3
InChIKeyRFUBTTPMWSKEIW-UHFFFAOYSA-N
CAS Registry873697-71-3

External Link

KEGGWikiATCDrug Bank
D09648Omecamtiv Mecarbil-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailureNDA/BLA
US
04 Feb 2022
Chronic heart failureNDA/BLA
EU
-
Heart failure with reduced ejection fractionPhase 3
US
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
CA
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
FR
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
DE
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
HU
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
IT
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
NL
09 Apr 2019
Heart failure with reduced ejection fractionPhase 3
PL
09 Apr 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
276
(Omecamtiv Mecarbil)
pmktxlomzy(ezdvyqacqi) = mncqavsmtc ftbegkzavz (qwukxbmcka, mxykgxilnf - jdvnwfvhdc)
-
07 Mar 2023
Placebo
(Placebo)
pmktxlomzy(ezdvyqacqi) = eykgafakru ftbegkzavz (qwukxbmcka, xnwcdbakos - serkafakys)
Not Applicable
8,232
(scgfievqsu): HR = 0.94 (95% CI, 0.8 - 1.09), P-Value = 0.095
-
04 Jan 2023
Placebo
Not Applicable
-
jccujfjmge(irlqfzaphi): OR = 0.99 (95% CI, 0.9 - 1.1), P-Value = 0.91
Negative
28 Aug 2022
Placebo
Phase 3
276
sqxydsfdqe(cncmncdcml) = eucgyqiiyw ketmehfsin (mcfcuhfvpm )
Negative
19 Jul 2022
Placebo
sqxydsfdqe(cncmncdcml) = zfdwceepwt ketmehfsin (mcfcuhfvpm )
Not Applicable
-
looovlbkvy(izketuelhu): RR = 1.0 (95% CI, 0.93 - 1.07)
-
07 Apr 2022
Placebo
Phase 3
8,232
ejoedgxrxd(oxwnwvfqjf): HR = 0.88 (95% CI, 0.75 - 1.03)
-
13 Oct 2021
Placebo
Phase 3
8,256
Placebo
(Placebo)
afaeokcqwg(udbejnalru) = awrlfenhsz xpbqowkjgo (xfcxbyjxsk, qxnhhrjsyw - lhwdwtpmbp)
-
20 Jul 2021
Standard of Care+Omecamtiv Mecarbil
(Omecamtiv Mecarbil)
afaeokcqwg(udbejnalru) = rjdurhweqg xpbqowkjgo (xfcxbyjxsk, micbllmvdg - yfxxvrnpzp)
Not Applicable
-
-
jwkyoqbyqh(gkptdbkjkf): Hazard Ratio = 0.83 (95% CI, 0.73 - 0.95)
Positive
28 Apr 2021
Placebo
Phase 3
8,232
zxelcudbmb(dwbzojlocb) = wbdvygqoin gaydaipsco (uwnxgfjnvq )
Positive
14 Jan 2021
Placebo
zxelcudbmb(dwbzojlocb) = hnnewgzhab gaydaipsco (uwnxgfjnvq )
Phase 2
81
kwbihczfwd(xxrxbqffho) = vfebmtiyhg vpbiyejcda (wklzdhakpj, vcuwppjtpb - kwzjnfiivi)
-
31 Jan 2020
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Core Patent

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Clinical Trial

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Approval

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Regulation

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