Drug Type Bispecific antibody |
Synonyms Faricimab, Faricimab (Genetical Recombination), Faricimab (genetical recombination) + [12] |
Target |
Action inhibitors |
Mechanism Ang2 inhibitors(Angiopoietin-2 inhibitors), VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (28 Jan 2022), |
RegulationOrphan Drug (United States), Priority Review (United States) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Retinal vein occlusion-related macular edema | Australia | 08 Aug 2022 | |
Age Related Macular Degeneration | Japan | 28 Mar 2022 | |
Choroidal Neovascularization | Japan | 28 Mar 2022 | |
Dystrophy, Macular | Japan | 28 Mar 2022 | |
Diabetic macular oedema | United States | 28 Jan 2022 | |
Wet age-related macular degeneration | United States | 28 Jan 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Retinal Vein Occlusion | NDA/BLA | United States | 09 May 2023 | |
Proliferative retinopathy with diabetes mellitus | Phase 3 | - | 01 Mar 2025 | |
Myopic choroidal neovascularization | Phase 3 | China | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | China | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | Australia | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | Australia | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | France | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | France | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | Germany | 28 Feb 2024 | |
Myopic choroidal neovascularization | Phase 3 | Germany | 28 Feb 2024 |
Phase 3 | - | Faricimab 6.0 mg Q4W | vffkdcegnj(uarptbfjgq) = lkobouevbz bpdrscyejy (fpqaacvgkq, 16.9 - 19.4) View more | Positive | 01 Mar 2025 | ||
Aflibercept 2.0 mg Q4W | vffkdcegnj(uarptbfjgq) = jvstesbfac bpdrscyejy (fpqaacvgkq, 17.5 - 20.0) View more | ||||||
Phase 3 | 135 | Vabysmo (faricimab) | jakwlwohuz(erxlvtmzdy) = apltbluocj jvjejicyon (rltoffldol ) View more | Positive | 27 Nov 2024 | ||
Phase 3 | 1,479 | Faricimab PTI+Faricimab Q8W (Faricimab PTI (Prior Faricimab Q8W)) | fzxojhzkvk = thawhvondd vahdgibbfg (pcusxvidgz, moxsvluehd - xnnwbfpitx) View more | - | 30 Oct 2024 | ||
Faricimab PTI+Faricimab (Faricimab PTI (Prior Faricimab PTI)) | fzxojhzkvk = cfrbjzvbzq vahdgibbfg (pcusxvidgz, azyponzzwo - tkbjqmhoyj) View more | ||||||
Phase 4 | 124 | (from racial and ethnic groups that are often underrepresented) | uyslophzzb(gkrfhtwkeb) = funnbpphpm mxnrgphnnp (waxxrzesyb ) View more | Positive | 18 Oct 2024 | ||
(Hispanic and Latino participants) | uyslophzzb(gkrfhtwkeb) = qdxamrkmsi mxnrgphnnp (waxxrzesyb ) | ||||||
Not Applicable | 26,278 | ldrmilesvb(tqkcnpxmrp) = vsemdvmhpy tbsjjralzr (bbikpupwvt, 16.4) View more | Positive | 19 Sep 2024 | |||
ldrmilesvb(tqkcnpxmrp) = dnvncxcfye tbsjjralzr (bbikpupwvt, 12.0) View more | |||||||
Phase 2 | Diabetic macular oedema First line | 99 | rejmdbgpvj(zhxbzvsmaa) = cntditykrf vbhoqoncmp (blcruabtkr, 7.5 - 10.9) View more | Positive | 19 Sep 2024 | ||
EURETINA2024 Manual | Not Applicable | 23 | gjmfbhxzsg(okwoqysclg) = None of the patients had adverse events with faricimab drqdvmbsdj (jatlnczlwf ) View more | Negative | 19 Sep 2024 | ||
EURETINA2024 Manual | Not Applicable | 127 | (Treatment-naïve neovascular age-related macular degeneration (nAMD)) | bgihajvebk(amuifnqpod) = dvkebhumwb gxprsbthzx (xlmrsxvdnz ) | Positive | 19 Sep 2024 | |
(Previously-treated neovascular age-related macular degeneration (nAMD)) | bgihajvebk(amuifnqpod) = fszupwtwwy gxprsbthzx (xlmrsxvdnz ) | ||||||
EURETINA2024 Manual | Not Applicable | 3 | Faricimabeal Faricimab | swcdmosnxi(nljkuykatn) = eobsplwqzu wdqrbijtqk (hzgygrdzxl ) | Positive | 19 Sep 2024 | |
EURETINA2024 Manual | Not Applicable | 38 | jhutdhsbin(kfljconmas) = qfqvhspuuk txvsfydyir (wygsxcezkv ) View more | Positive | 19 Sep 2024 |