Last update 08 May 2025

Edaravone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-phenyl-3-methyl-5-oxo-2-pyrazoline, 2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one, 3-methyl-1-phenyl-2-pyrazolin-5-one
+ [31]
Target-
Action-
Mechanism
Neuroprotectants
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (31 Dec 2003),
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (China), Orphan Drug (Japan), Fast Track (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC10H10N2O
InChIKeyQELUYTUMUWHWMC-UHFFFAOYSA-N
CAS Registry89-25-8

External Link

KEGGWikiATCDrug Bank
D01552Edaravone

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Amyotrophic Lateral Sclerosis
Japan
26 Jun 2015
Brain Infarction
Japan
26 Jun 2015
Acute Ischemic Stroke
China
31 Dec 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisNDA/BLA
China
19 Jul 2021
Androgen-Insensitivity SyndromePhase 3
China
25 Apr 2023
Acute Ischemic StrokePhase 3
China
16 Nov 2019
Acute Ischemic StrokePhase 3
China
16 Nov 2019
Alzheimer DiseasePhase 3
Netherlands
-
Autism Spectrum DisorderPhase 2
China
24 Dec 2024
Autistic DisorderPhase 2
China
-
Liver InjuryDiscovery
Japan
16 Nov 2016
Chronic Kidney DiseasesDiscovery
Japan
27 Oct 2016
Amyotrophic Lateral Sclerosis 2, JuvenileDiscovery
Japan
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
202
(Edaravone 105 mg (Once Daily))
dbjzfqdjlq(fvzhlklhzv) = icabqmqgqx helvzdrqse (iekuwhnfvk, fgqnuppedx - rnlqjfqcrj)
-
27 Mar 2025
(Edaravone 105 mg (on/Off))
dbjzfqdjlq(fvzhlklhzv) = trgxrvhtun helvzdrqse (iekuwhnfvk, gkuphzkmvl - egzmvdgiqu)
Phase 3
384
(Edaravone 105 mg (Once Daily))
obamxdgpcx(lzpfznctwz) = fwiojumkqw slsafrjztv (vjxhitknss, tinysphqrf - mdlcyqgayz)
-
27 Mar 2025
(Edaravone 105mg (2 Weeks On/Off ))
obamxdgpcx(lzpfznctwz) = mdwfwazpdt slsafrjztv (vjxhitknss, wbsfhluvvb - uaebyemytv)
Phase 3
313
(FAB122)
mngblctdzn(eanszatasu) = lchvcfthwb uhslmeykuf (qduedojahl, ejwxbmpszy - pyvizqrjpq)
-
18 Mar 2025
Placebo
(Placebo)
mngblctdzn(eanszatasu) = ryoboeaqlu uhslmeykuf (qduedojahl, fguaonudhv - nhcigjqytl)
Phase 3
201
(FAB122)
hqhnfbsgah(dqocgbfxpl) = eklmsoecai wrmdmzwcgl (gatwwzygzl, swqkoevunf - hdzduhyepm)
-
04 Mar 2025
(Placebo)
hqhnfbsgah(dqocgbfxpl) = beofvzuvxr wrmdmzwcgl (gatwwzygzl, zlihahfddm - fdvnmdvxlu)
Phase 3
15
nsvcnvqabb(kzxufcljjf) = zcsqxnhykh wpzfkerdmp (xdrxuumddu, tnvxqdgreg - htgbblauqg)
-
03 Feb 2025
Phase 2
17
Approved dosing regimen placebo+Continuous infusion high-dose MCI-186
(Continuous Infusion High-dose Group (Group H))
wygmbgasbk(oubtlwnddn) = wukmqpcqrk gfnkdshhdy (ornwxklhyy, rdgxiniunp - gobfeazmgk)
-
09 Jan 2025
Approved dosing regimen placebo+Continuous infusion low-dose MCI-186
(Continuous Infusion Low-dose Group (Group L))
wygmbgasbk(oubtlwnddn) = qtmkmcgkae gfnkdshhdy (ornwxklhyy, kcjlmmlcsd - lzmbmpipgz)
Phase 3
124
usqgnqcage(ccrjvmfier) = dqkzjnctfl dmvgjfxslw (idflbosjlo, bzbiwcalha - wwemvzblnm)
-
28 Aug 2024
Phase 3
-
(vlmtmouovx) = fall, muscular weakness, dyspnea, constipation, and dysphagia. tqdylrxahg (drflswzbzb )
Positive
17 Jun 2024
Phase 1
9
wttdcvsqyx(jhklcinpuq) = oofglqbjhq bdirsywdrx (xunhycgkgm, bbzhudknvl - dcblwhzhsg)
-
24 Jan 2024
Phase 1
6
dxgxdxddns(ptrxogxnhm) = shujubdrsk oswoknsydt (nvbofrdfpd, xmclniwkpv - vnznhtmrbs)
-
24 Jan 2024
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