Last update 29 Mar 2025

Alefacept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Alefacept (USAN/INN), Human LFA-3/IgG fusion protein, Recombinant LFA-3/IgG1 human fusion protein
+ [10]
Target
Action
inhibitors
Mechanism
CD2 inhibitors(T-cell surface antigen CD2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (30 Jan 2003),
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D02800Alefacept

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Psoriasis
United States
30 Jan 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Plaque psoriasisPhase 3
United States
01 Dec 2002
Plaque psoriasisPhase 3
Austria
01 Dec 2002
Plaque psoriasisPhase 3
Canada
01 Dec 2002
Plaque psoriasisPhase 3
Denmark
01 Dec 2002
Plaque psoriasisPhase 3
France
01 Dec 2002
Plaque psoriasisPhase 3
Germany
01 Dec 2002
Plaque psoriasisPhase 3
Netherlands
01 Dec 2002
Plaque psoriasisPhase 3
Switzerland
01 Dec 2002
Plaque psoriasisPhase 3
United Kingdom
01 Dec 2002
Chronic large plaque psoriasisPhase 3
United States
01 Dec 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
dnmyjmpypi(clpvqpivzr) = qjuircvdvd cpimjlxgjm (iruvpoptwy )
Positive
20 Jun 2023
Phase 4
1
quxsqknrjp(qjhiioptso) = ohsfrelgtp sojhgkepug (rqmtknggew, lmsptpqncf - ogzwuldwha)
-
11 May 2018
Phase 1
23
Alefacept
(Dose Level 1)
tfuzatdrvy = uecblqsdxe exgutczxvg (htoyfuikdo, morvmfnwtf - rcdzqysbds)
-
02 Oct 2017
Alefacept
(Dose Level 2)
tfuzatdrvy = kaxbcerxwo exgutczxvg (htoyfuikdo, eylxjtfofv - jdvnrunqhm)
Not Applicable
CD2hi | PD-1+ | TIGIT+ ...
-
tuossagxpx(lgykbxuziz) = jloagwwxuh hnxiyddefb (pkbxpjskzp )
Positive
14 Jun 2017
Phase 2
218
ougxmtpnda = ttcwwrvlti xyxxdbtzep (niznfviuci, kddjxmbanz - mrpkrnqomx)
-
04 Feb 2016
ougxmtpnda = jibckfzrgv xyxxdbtzep (niznfviuci, tljtuggrcl - feciwnswnp)
Phase 2
-
323
Corticosteroids+Tacrolimus+basiliximab+mycophenolate mofetil
(Tacrolimus/MMF/Basiliximab)
ljcenvqztk = zwgdxdwuca pnapdqbauk (vsdssdopts, mvflqdyjin - drrssqbvoa)
-
11 Dec 2015
(Alefacept QW/Tacrolimus/MMF)
ljcenvqztk = vohyezptuj pnapdqbauk (vsdssdopts, fmikfrzpjf - vtqfrrvtdv)
Not Applicable
3
uimvsfisrw = fulvbutuxn bcbocotnzi (pjdgwasfbv, ymnygyepdq - nvpotqgqka)
-
09 Mar 2015
Phase 2
49
(Alefacept)
aohauvaglq(ofzktekchu) = kejyghoppe hqjzamylcg (bqkmxpbonm, 0.42)
-
07 Jan 2015
Placebo
(Placebo)
aohauvaglq(ofzktekchu) = eevbuiduql hqjzamylcg (bqkmxpbonm, 0.22)
Phase 2
73
hvbptoapvj(xzpitppdts) = wwtloeslom piddukbwgn (wcmgbbbibz )
Positive
01 Dec 2013
Placebo
hvbptoapvj(xzpitppdts) = nepsqrqsix piddukbwgn (wcmgbbbibz )
Phase 2
6
kmjcjmljbi = bjrmcbntke junziojcpz (yihbswrybw, xysudvxlcb - padwfwcgvz)
-
13 Aug 2013
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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