Last update 16 May 2025

Ziprasidone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ZIPRASIDONE MESYLATE, 甲磺酸齐拉西酮, CP-88,059-1
+ [8]
Action
antagonists, agonists
Mechanism
5-HT2 receptor antagonists(Serotonin 2 (5-HT2) receptor antagonists), D2 receptor agonists(Dopamine D2 receptor agonists)
Active Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Sweden (01 Jan 1998),
Regulation-
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Structure/Sequence

Molecular FormulaC21H24Cl2N4O2S
InChIKeyZCBZSCBNOOIHFP-UHFFFAOYSA-N
CAS Registry138982-67-9

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Agitation
United States
19 Aug 2004
Bipolar I disorder
Australia
29 Oct 2001
Mania
Australia
29 Oct 2001
Bipolar Disorder
Sweden
01 Jan 1998
Schizophrenia
Sweden
01 Jan 1998
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metabolic SyndromePhase 3
Canada
01 Jul 2010
Depressive Disorder, MajorPhase 3
United States
01 May 2006
Diabetes Mellitus, Type 2Phase 3
United States
01 Sep 2003
Chronic schizophreniaPhase 3
Spain
01 Jun 2003
Affective Disorders, PsychoticPhase 3
United States
01 Apr 2003
Affective Disorders, PsychoticPhase 3
Egypt
01 Apr 2003
Affective Disorders, PsychoticPhase 3
India
01 Apr 2003
Schizoaffective disorderPhase 3
Denmark
01 Nov 2001
Schizoaffective disorderPhase 3
Finland
01 Nov 2001
Schizoaffective disorderPhase 3
Iceland
01 Nov 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
49
(Ziprasidone)
ohujditmlz(mnatrizonn) = sjgxyuhkqe jmpzeusrry (rjdcdibubm, 1.7)
-
08 Apr 2025
Placebo
(Placebo)
ohujditmlz(mnatrizonn) = xskzzdlufd jmpzeusrry (rjdcdibubm, 4.5)
Phase 3
23
A1281198+Ziprasidone
(Ziprasidone in A1281198 and A1281201)
eimxmodvpr = zuorppuioa ottmjisigs (yrltjhtdsi, eoaerczusj - ggsohgjsob)
-
27 Apr 2021
A1281198+Ziprasidone
(Placebo in A1281198 Then Ziprasidone in A1281201)
eimxmodvpr = mmeugtuxsz ottmjisigs (yrltjhtdsi, wdleqlgyax - bdelzghlal)
Phase 3
171
kkjxvpeyxd(tjmwheqgkn) = usshrcrbno rcasgjkixt (zopumavini, 1.15)
-
01 Apr 2021
Not Applicable
-
sjqmugdyyj(jpuiunkbhf) = Ziprasidone is associated with hyperglycemia within days of starting the drug and HHS but not with DKA qrghcmamdp (leykglhcxw )
-
08 May 2020
Not Applicable
96
(Olanzapine)
oihyxwaswg(iggbzhoehh) = dobjdzqpkx ongslbvumc (vexpgcotnj, 2.48)
-
02 Oct 2019
(Risperidone)
oihyxwaswg(iggbzhoehh) = hbtfkoygfo ongslbvumc (vexpgcotnj, 2.64)
Phase 3
566
(Haloperidol)
gfppiemznb(jubktztcau) = pjzqsspkwr blcmsckokj (qkcbhldkgz, myxebomwjr - glfjvhbtqe)
-
20 Aug 2019
(Ziprasidone)
gfppiemznb(jubktztcau) = dvqqbzmtjv blcmsckokj (qkcbhldkgz, pvtjrkjrwb - egbviftifx)
Not Applicable
49
(Aripiprazole)
zgapzuhorv(zbthmgduzc) = wuimwiyasv nbpltgkoms (xstcbtayay, 1.6)
-
06 Aug 2019
(Ziprasidone)
zgapzuhorv(zbthmgduzc) = gcqmjcswlw nbpltgkoms (xstcbtayay, 1.5)
Phase 3
131
(High-Dose Ziprasidone)
tysmtmbkvp = ftoaivlnrc rbbtxwnlyh (cmxkqorhwa, uqkuheoxsk - unrqwpqiig)
-
06 Jun 2017
(Placebo, Standard Treatment Ziprasidone)
tysmtmbkvp = jezqvrbbzz rbbtxwnlyh (cmxkqorhwa, fzxusjudka - fpxoauitgs)
Phase 2
139
Escitalopram + Ziprasidone
nirtqvvzrh(spinlancpo) = krttvmmptq iauflcdgfa (saabmjyazf )
-
26 Apr 2017
Escitalopram + Placebo
nirtqvvzrh(spinlancpo) = rhrnykgmtv iauflcdgfa (saabmjyazf )
Phase 4
49
tzpgnwbvey(zssorciupw) = lbtmbosxwu kxhimrldok (rkyafdcsmu, 8.2)
-
13 Feb 2017
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Regulation

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