Delving into the Latest Updates on Eupatilin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Eupatilin/jaceosidin, Jaceosidin/eupatilin, Stillen

+ [2]

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System DisordersImmune System Diseases

Active Indication

GastritisStomach UlcerAnaphylaxis

Inactive Indication-

Originator Organization

Dong-A Pharmaceutical Co., Ltd.

Active Organization

Sungkyunkwan University

Dong-A Pharmaceutical Co., Ltd.Samsung Biomedical Research Institute

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

South Korea (29 Apr 2005),

GastritisStomach Ulcer

Regulation-

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Structure/Sequence

Molecular FormulaC18H16O7

InChIKeyDRRWBCNQOKKKOL-UHFFFAOYSA-N

CAS Registry22368-21-4

This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.

01 Jul 2025·Food Chemistry

Identifying key contributors to the sweet aftertaste of raw Pu-erh tea through analytical and sensory methods

Article

Author: Yi, Zhibiao ; Gu, Ying ; Yi, Lunzhao ; Yuan, Xiaoping ; Chen, Xian ; Chai, Chunrong ; Feng, Min ; Ruan, Linguang ; Hu, Yongdan

In this study, the key components contributing to raw Pu-erh tea (RAPT) sweet aftertaste were identified. Six RAPTs were investigated through sensory evaluation, mass spectrometry, and taste addition experiments, and 96 taste components of tea infusion were annotated and analyzed. Saliva analysis after drinking tea revealed that 27 components present in tea remained in the mouth. On the basis of the results of the multivariate statistical analyses, we hypothesized that alkaloids and flavonoids might influence the sweet aftertaste strength of RAPT. Finally, the results of the taste addition experiments revealed that theophylline and rutin are key components that significantly influence the sweet aftertaste intensity of the RAPT. This strategy can be used as a methodology for analyzing the taste of tea, and the results can provide an evaluation index for evaluating the quality of RAPT.

01 May 2025·Food Chemistry

A design of Tetrastigma hemsleyanum's flavonoid loaded polyvinylpyrrolidone nanoparticles for improving its bioavailability and biological activities

Article

Author: Li, Dongbin ; Ruan, Xiao ; Zheng, Shaojian ; Xu, Fengjiao ; Yang, Li ; Yu, Minfen ; Wang, Qiang ; Qu, Aili

Flavonoids in plant extracts exhibit significant biological activities but are limited by their low bioavailability. This research aimed to improve the functional properties by synthesizing polyvinylpyrrolidone (PVP) nanoparticles using flavonoids derived from T. hemsleyanum. 208 flavonoids were identified using ultrahigh-performance-mass/mass spectrometry and used for nanoparticle preparation. The nanoparticles exhibited 24 % and 55 % higher equilibrium dissolution rates in simulated intestinal and gastric fluids than free flavonoids. With spherical morphologies, 100 nm size and - 26.7 mV zeta potential, these nanoparticles showed remarkable improvements in biological activities, including 1.5-fold enhancement in antioxidant capacity, HeLa cell inhibition, and antimicrobial efficacy, and a 5-fold increase in anti-inflammatory effects compared to unencapsulated flavonoids. This research has established a methodological system that could effectively enhance the utilization rate of flavonoids in plant extracts, offering promising potential for application in functional foods.

100 Deals associated with Eupatilin

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	A02B	-

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Gastritis	South Korea	Dong-A Pharmaceutical Co., Ltd.	29 Apr 2005
Stomach Ulcer	South Korea	Dong-A Pharmaceutical Co., Ltd.	29 Apr 2005

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Anaphylaxis	Discovery	South Korea	Samsung Biomedical Research Institute	20 Mar 2005
Anaphylaxis	Discovery	South Korea	Sungkyunkwan University	20 Mar 2005

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


UEGW2022	Not Applicable	Hemorrhage	-	Eupatilin	hetvmzjbyh(znklwkqstd) = tpbggcncwm faakxdcqpo (cuvmyqfmzf )	-	09 Oct 2022
				Aspirin	hetvmzjbyh(znklwkqstd) = zmlkuccext faakxdcqpo (cuvmyqfmzf )
UEGW2019	Not Applicable	Gastroesophageal Reflux	-	Pantoprazole 40mg + DA-5204	(vffydchsnu) = xsphsohxrv qnvbvpwvvm (ukrqxlrzaf )	-	01 Oct 2019
				Pantoprazole 40mg + Placebo	(vffydchsnu) = xiygukkkwn qnvbvpwvvm (ukrqxlrzaf )
NCT02282670 (Pubmed)	Phase 3	Gastritis	434	DA-5204	egkdzzqaoz(rnhlhwccum) = AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group uexfqbxwoc (emireyztis )	Positive	01 Nov 2017
				DA-9601