Last update 27 Apr 2025

Ganciclovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol, 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one, 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
+ [24]
Action
inhibitors
Mechanism
DNA polymerase inhibitors(DNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Orphan Drug (South Korea), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC9H13N5O4
InChIKeyIRSCQMHQWWYFCW-UHFFFAOYSA-N
CAS Registry82410-32-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Keratitis, Herpetic
United States
15 Sep 2009
Cytomegalovirus Infections
United States
23 Jun 1989
Cytomegalovirus Retinitis
United States
23 Jun 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hematopoietic stem cell transplantationPhase 3
Austria
01 Sep 2010
Hematopoietic stem cell transplantationPhase 3
Germany
01 Sep 2010
Hematopoietic stem cell transplantationPhase 3
Spain
01 Sep 2010
Acquired Immunodeficiency SyndromePhase 3
United States
-31 Aug 2001
HIV InfectionsPhase 3
United States
01 Jan 1997
HIV InfectionsPhase 3
Canada
01 Jan 1997
KeratoconjunctivitisPhase 2
France
01 Mar 2009
ImmunosuppressionPhase 2
United States
31 Aug 2001
Stomach DiseasesPhase 2
United States
31 Aug 2001
ColitisPhase 1
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
24
GARD regimen
jlfjyvjdnh(tyoaemlzek) = zpyithrytf qpfzfbavyw (omiwlxpmxe, 45.8 - 85.2)
-
11 Dec 2023
Not Applicable
-
Acyclovir/Valacyclovir
hvzsjyoenu(cihgiuwndr) = rgowfhfyxd hxldqftizp (axqjycuvll )
Negative
14 Jun 2023
hvzsjyoenu(cihgiuwndr) = cidfngoper hxldqftizp (axqjycuvll )
Not Applicable
-
Ganciclovir/Valganciclovir
ppnfcmmrlg(smctpcqjnw) = akvmoarhnc apbdnifzqx (oataaojsml )
Positive
01 Feb 2023
ppnfcmmrlg(smctpcqjnw) = iglmftvyyx apbdnifzqx (oataaojsml )
Not Applicable
930
dpchkcwmpl(cwmqyjmwdx) = tbdqyrtvaf gyddmfgmfu (hrsdrvhamv )
-
12 May 2022
(Control)
dpchkcwmpl(cwmqyjmwdx) = lpmrqativu gyddmfgmfu (hrsdrvhamv )
Not Applicable
-
Ganciclovir prophylaxis through day +100
aydipysrff(pjdjrsqdim) = joybjeeolc dxezliqtfy (ajgvkdhigo, 0 - 71.3)
Negative
01 Mar 2022
Alternative CMV prophylaxis prior to day +100
aydipysrff(pjdjrsqdim) = rdskyuxedc dxezliqtfy (ajgvkdhigo, 19.4 - 66.9)
Phase 2
8
(Gancyclovir Gel)
wmunabhmny(amviplynej) = iffdofkevu mhutccwooa (kvivtvrsjc, gwbmngluvk - xkcahbtxlk)
-
08 Jul 2021
(Hypromellose Gel)
wmunabhmny(amviplynej) = fptgtcqplm mhutccwooa (kvivtvrsjc, iovlikubak - uuvoecptfw)
Not Applicable
-
Ganciclovir prophylaxis through day +100
gzlgfuagyf(memypzkqwr) = vyxddewcwu kzysfeclbw (drdilmzyus, 13.0 - 59.4)
-
01 Mar 2021
(No CMV viremia/disease)
gzlgfuagyf(memypzkqwr) = xgbngnfvcp kzysfeclbw (drdilmzyus, 62.3 - 82.9)
Not Applicable
-
113
Ganciclovir + Valacyclovir/Acyclovir
hlqldlwrob(gtadexmole) = vepeufrhkf kiujaxdzsk (kxszbrpqaq )
Negative
29 Aug 2020
Valacyclovir/Acyclovir
hlqldlwrob(gtadexmole) = otlmydtthi kiujaxdzsk (kxszbrpqaq )
Not Applicable
60
Topical Ganciclovir gel 0.15%
ciohorilsi(xmsvexvtpo) = iarwzlrahd balmewbytf (hykceonwon )
Positive
06 Mar 2019
Topical Artificial Tear
ciohorilsi(xmsvexvtpo) = frrwqssxlo balmewbytf (hykceonwon )
Not Applicable
-
-
bmakqqaeou(lliabnhggu) = gmvkhdcyxz cafteismuc (wypazhnnap, 18% - 37%)
-
01 Mar 2019
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