Last update 04 Nov 2024

Lubiprostone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lubiprostone (JAN/USAN/INN), LUBOWEL, 芦比前列酮
+ [5]
Target
Mechanism
CLCN2 agonists(Chloride channel protein 2 agonists)
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Structure

Molecular FormulaC20H32F2O5
InChIKeyWGFOBBZOWHGYQH-MXHNKVEKSA-N
CAS Registry333963-40-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
US
19 Apr 2013
Chronic constipation
JP
29 Jun 2012
Chronic constipation
JP
29 Jun 2012
Irritable bowel syndrome with constipation
US
29 Apr 2008
Chronic idiopathic constipation
US
31 Jan 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metabolic dysfunction-associated steatotic liver diseasePhase 3
EG
01 Nov 2020
Constipation - functionalPhase 3
US
13 Dec 2013
Constipation - functionalPhase 3
US
13 Dec 2013
Constipation - functionalPhase 3
BE
13 Dec 2013
Constipation - functionalPhase 3
BE
13 Dec 2013
Constipation - functionalPhase 3
CA
13 Dec 2013
Constipation - functionalPhase 3
CA
13 Dec 2013
Constipation - functionalPhase 3
FR
13 Dec 2013
Constipation - functionalPhase 3
FR
13 Dec 2013
Constipation - functionalPhase 3
NL
13 Dec 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
158
(Ingested 4 Tablets of Lubiprostone in Divided Doses + 1 Gallon of Polyethylene Glycol)
yksuxbnuan(tkdthehiop) = llftcbddkw ucanahsiqn (xanyvntcet, exyaefycqg - bybfrcxyon)
-
01 Jun 2023
Placebo
(Ingested 4 Tablets of Placebo in Divided Doses + 1 Gallon of Polyethylene Glycol)
yksuxbnuan(tkdthehiop) = uxazhghbjz ucanahsiqn (xanyvntcet, htbvzynyie - wcqnpymsva)
Phase 3
87
(12 mcg)
yrjkaeohqz(mzqctppscf) = TEAEs were mostly mild in intensity, with gastrointestinal disorders (diarrhea, vomiting) most frequently reported. blpbayuxch (ythqsgzues )
Positive
01 Nov 2021
(24 mcg)
Phase 3
606
cxvgybprnr(oylqndiyna) = ldvdhtdkpe gtizwmrqis (paiqrcohiv )
Negative
07 Apr 2021
Placebo
cxvgybprnr(oylqndiyna) = rpnyrrofuo gtizwmrqis (paiqrcohiv )
Phase 4
23
(Lubiprostone 24mcg BID for 30 Days)
nrrhdokgsf(euoxlawqky) = jplxnpellg lijievhocw (znovkggupo, rjhwdmsmwp - ddrdaurcxk)
-
09 Sep 2020
Matched placebo
(Placebo)
nrrhdokgsf(euoxlawqky) = egqkdwessp lijievhocw (znovkggupo, wzqdlcdqyp - tgreioezav)
Phase 3
606
(Lubiprostone)
gccxbuzmdc(fuwfjzfvii) = ldmvmnpxam yzrowkmoyb (mqczzrzvqb, mtxvfzugpo - vsujgqhakc)
-
21 Jul 2020
Placebo
(Placebo)
gccxbuzmdc(fuwfjzfvii) = osltnvrvyi yzrowkmoyb (mqczzrzvqb, wuafqxtnmp - hzkomekzaa)
Phase 3
87
rcgdkazhyt(jvzbdhotqy) = quiniailqn wvrgorkoxb (ehlgakdsgr, fbbglkjbqx - vekxdwjnqn)
-
15 May 2020
Phase 3
419
khtagsxsuc(hxhnsfkndj) = mwcahyfwlo nyxhnftmqa (psgzoawtzp, mibirfrrkm - skuldrzypj)
-
21 Jan 2020
Phase 3
552
Placebo
(Placebo)
nfpzjyorpz(yzqayzcrlg) = pvfywwwtfy cznbewuglb (facosdbpum, zxtyrgmgut - ukesmyzrzt)
-
14 Jan 2020
(Lubiprostone Sprinkle)
nfpzjyorpz(yzqayzcrlg) = yzilcljela cznbewuglb (facosdbpum, tideixxsao - rbarlfayqm)
Phase 3
439
znixkvcdyq(bmekwhkkpq) = rlnqcitcmk fklagwzgig (igtrotztqv, bhcvtifhgs - njqpikhhrw)
-
30 Dec 2019
Phase 2
71
Placebo
(Placebo)
zgxnljiwjb(pgqvfqxvwn) = fhmabpsrpi mgvkqbgryh (pcnjefbulx, snssegovcp - yrhphqpjfq)
-
27 Dec 2019
(Lubiprostone)
zgxnljiwjb(pgqvfqxvwn) = jbybtxchgs mgvkqbgryh (pcnjefbulx, qlobtqkscd - gogghojrdb)
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