Delving into the Latest Updates on Sodium Citrate Hydrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Anhydrous sodium citrate, Anhydrous trisodium citrate, Anticoagulant Sodium Citrate

+ [13]

Target-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Acidosis

Inactive Indication-

Originator Organization

Kozakai Pharmaceutical Co. Ltd.

Active Organization

Kozakai Pharmaceutical Co. Ltd.Wrafton Laboratories Ltd.

Tianjin Jinyao Pharmaceutical Co., Ltd.

+ [1]

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (01 Mar 1955)

Regulation-

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Structure/Sequence

Molecular FormulaC6H10NaO8

InChIKeyOAGSFHDUINSAMQ-UHFFFAOYSA-N

CAS Registry18307-19-2

View All Structures (2)

The goal of this pilot study is to assess the feasibility and impact of using sodium citrate nasal spray as an adjunct to olfactory retraining in participants with long-term post-COVID-19 olfactory dysfunction.
The main questions it aims to answer are:
Is sodium citrate nasal spray in addition to smell retraining feasible for participants to use in terms of participant need/desire, adherence, and adverse events?
Does sodium citrate nasal spray in addition to smell retraining further improve smell as compared to normal saline spray and smell retraining?
Participants will:
Provide consent for enrollment.
Undergo smell testing via Sniffin' Sticks.
Use a nasal spray (either sodium citrate or normal saline) followed by olfactory retraining twice a day for 12 weeks.
Return for follow-up Sniffin' Sticks testing.
Researchers will compare the sodium citrate group and the normal saline group to determine differences in smell improvement.

Start Date01 Dec 2023

Sponsor / Collaborator

The University of North Carolina at Chapel Hill

TCTR20231106002

/ RecruitingPhase 4IIT

Efficacy of 5% Trisodium Citrate and Low Dose Heparin as Catheter-Locking Solution for Central Venous Hemodialysis Catheters: A Randomized Controlled Study

Start Date25 Jun 2023

Sponsor / Collaborator-

TCTR20230107004

/ RecruitingPhase 2/3IIT

The efficacy of trisodium citrate versus heparin for permanent cuffed tunneled catheter lock in chronic hemodialysis patients

Start Date19 Jun 2023

Sponsor / Collaborator-

100 Clinical Results associated with Sodium Citrate Hydrate

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100 Translational Medicine associated with Sodium Citrate Hydrate

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100 Patents (Medical) associated with Sodium Citrate Hydrate

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1,500

Literatures (Medical) associated with Sodium Citrate Hydrate

01 May 2025·Journal of Environmental Sciences

Sodium citrate enhancing electrodeposition of metallic arsenic from toxic trivalent arsenic and the mechanism understanding

Article

Author: Chen, Hang ; Tan, Wen ; Xu, Tingyu ; Shi, Yanru ; Zhong, Shuiping ; Tang, Ding ; Weng, Wei

Electrochemical conversion of hypertoxic trivalent arsenic to value-added metallic arsenic can not only contribute to pollution abatement, but also resources reutilization, therefore being widely explored. Electrochemical reduction of trivalent arsenic as a promising way is widely explored. However, the high efficiency conversion is retarded by the sluggish reduction kinetics of AsO₃^3- and fierce evolution of side products of both H₂ and toxic AsH₃. Herein, by using the sodium citrate as the additive, the current efficiency for metal arsenic production is increased greatly from 60% to 91%, with the accompanied evolution of hypertoxic AsH₃ being restrained from 0.15 Nm³/t_As to 0.022 Nm³/t_As, promising a high-efficiency and green process. The electrochemical tests and electrode surface characterizations as well as DFT calculations indicate that the added sodium citrate promotes both the diffusion of reactive AsO₃^3- towards the cathode and its subsequent adsorption on the Ti cathode, contributing to smoother reduction for generating metal arsenic, with the evolution of toxic AsH₃ being hindered at the same time. The results can provide new insights for the high-efficiency and greener conversion of hypertoxic trivalent arsenic to value-added metallic arsenic.

01 Feb 2025·Transfusion and Apheresis Science

Comparison of anticoagulant combinations used in granulocyte apheresis

Article

Author: Çınar, Olgu Erkin ; Ugurlu, Bera Omer ; Akyol, Tulay Karaagac ; Ozcebe, Osman

Our study retrospectively examines the number of granulocytes in the products of donors who donated granulocytes between January 2016 and September 2020 at the Hacettepe University Faculty of Medicine Blood Bank. The effects of acid-citrate-dextrose (ACD), trisodium citrate + hydroxyethyl starch (TCC + HES) and ACD + HES combinations used in the apheresis procedure on the granulocyte count of apheresis products were examined. As a result of study, it was seen that the type of anticoagulant combination used during apheresis significantly affected the number of granulocytes collected.

01 Jan 2025·International Journal of Biological Macromolecules

Variation of nanoparticles in pickering emulsion optimize the physical, control-release and sustained antioxidant properties of hydroxypropyl methylcellulose based microporous film

Article

Author: Qian, Jian-Ya ; Ren, Yi-Ping ; Zhang, Liang ; Guo, Ke-Jun ; Zhang, Yu-Qing ; Ma, Jin-Ke ; Yang, Jie ; Chen, Ying

The proper encapsulation of liposoluble tea polyphenols (LTP) is expected to better protect oil system. Chitosan hydrochloride-carboxymethyl starch (CHC-CMS) nanoparticles-based Pickering emulsions and hydroxypropyl methylcellulose/sodium citrate (HPMC/SC) microporous film were combined to embed and control-release LTP. With the CHC:CMS ratio varied from 1:0.5 to 1:2, the average size of LTP droplets of Pickering emulsion increased from 6.0 μm to 8.5 μm, the average area of cross-sectional pores of functional films increased from 1.78 μm² to 3.22 μm², the water vapor permeability of functional films increased from 2.02 × 10^-10 to 2.44 × 10^-10 g·mm^-1·s^-1·Pa^-1, the light transmittance and the quantity of cross-sectional pores decreased. The release ratio first increased (<24 days) and then remained stable (≥24 days), the stable release ratio was positively correlated with the size of the emulsion droplets in the emulsion and the size of cross-sectional pores in the film. Functional films had better protection effect on oil than free LTP during later storage period (≥32 days), among which, functional film containing CHC-CMS 1:2 showed optimal sustained antioxidant effect on Perilla seed oil, which corresponded well to its highest stable release ratio.

1

News (Medical) associated with Sodium Citrate Hydrate

06 Nov 2017

·www.bioportfolio.com

Sodium CitrateChina Market Status and Trend Report 20132023 [Report Updated: 23102017] Prices from USD $2980

Report Summary Sodium CitrateChina Market Status and Trend Report 20132023 offers a comprehensive analysis on Sodium Citrate industry, standing on the readers' perspective, delivering detailed market data and penetrating insights. No matter the client is industry insider, potential entrant or investor, the report will provides useful data and information. Key questions answered by this report include: Whole China and Regional Market Size of Sodium Citrate 20132017, and development forecast 20182023 Main market players of Sodium Citrate in China, with company and product introduction, position in the Sodium Citrate market Market status and development trend of Sodium Citrate by types and applications Cost and profit status of Sodium Citrate, and marketing status Market growth drivers and challenges The report segments the China Sodium Citrate market as: China Sodium Citrate Market: Regional Segment Analysis Regional Consumption Volume, Consumption Volume, Revenue and Growth Rate 20132023: North China Northeast China East China Central South China Southwest China Northwest China China Sodium Citrate Market: Product Type Segment Analysis Consumption Volume, Average Price, Revenue, Market Share and Trend 20132023: Food Grade Pharmaceutical Grade Industrial Grade China Sodium Citrate Market: Application Segment Analysis Consumption Volume and Market Share 20132023; Downstream Customers and Market Analysis Food Beverage Industry Cleaners Detergents Industrial Applications Healthcare Industry China Sodium Citrate Market: Players Segment Analysis Company and Product introduction, Sodium Citrate Sales Volume, Revenue, Price and Gross Margin: Cargill Citrique Belge Gadot Biochemical Industries Panchem Corporation Hunan Dongting Citric Acid Chemicals Fbc Industries Posy Pharmachem Fuso Natural Biological Cofco Biochemical Capchem Lianyungang Mupro Fi YixingUnion Debang Fine Chemical Shuren Kechuang In a word, the report provides detailed statistics and analysis on the state of the industry; and is a valuable source of guidance and direction for companies and individuals interested in the market.

100 Deals associated with Sodium Citrate Hydrate

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External Link

KEGG	Wiki	ATC	Drug Bank
D01781	Sodium Citrate Hydrate	B05CB02	DB09154

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Acidosis	CN	Tianjin Jinyao Pharmaceutical Co., Ltd.	01 Jan 1981

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04139525 (Pubmed \| BMC Nephrol)	Not Applicable	Kidney Failure, Chronic	5	regional citrate anticoagulation with medium cut-off membrane (Regional citrate anticoagulation)	uzhhbjfzli(bdmdfugbyp) = ljytmhpxoj tvwgphokms (sfxlnukcpk ) View more	-	27 Oct 2022
FP541 (ERA2012)	Not Applicable	-	304	Trisodium citrate 46.7%	wvsfmfitmr(pjprxjmmgj) = imdxcluhcx eyhsdtjmdg (ibpjzkjhkz ) View more	Negative	01 May 2012
				Heparin	wvsfmfitmr(pjprxjmmgj) = dmqjzwmlzh eyhsdtjmdg (ibpjzkjhkz ) View more
ASN2011	Not Applicable	-	-	Routine Heparin (4168U/ml)	jrikxfsyjd(ubpzrqmoiz) = gckoyktcqg jbxhnyfxcy (ufertijaot )	Positive	08 Nov 2011
				Trisodium CitrateHeparinitrate (Low Heparin (2084U/ml))	jrikxfsyjd(ubpzrqmoiz) = arxqwofckl jbxhnyfxcy (ufertijaot ) View more
ASN2011	Not Applicable	Hemorrhage	6	Trisodium citrate 4%	(raxpubyxto) = Adverse events didn’t occur, safety laboratory measurements stayed within normal ranges fyhuzocgld (efyboxlxza )	Positive	08 Nov 2011
				Trisodium citrate 30%
ASN2011	Not Applicable	Catheter-Related Infections	-	Sodium Citrate 4%	(knasmigmaa) = manvucdlid kapnmmbfcg (borqqfpygs ) View more	Positive	08 Nov 2011
				Heparin 5,000 units/ml	(knasmigmaa) = amlsfradlk kapnmmbfcg (borqqfpygs ) View more
Pubmed \| Nephrol Dial Transplant	Not Applicable	Hemodialysis complication	6	Trisodium citrate 30%	mdwyxbgcvl(mzeyrpyukc) = gifbpmqkfx jpbmckuaxs (fgunonaqld )	-	01 Apr 2010
				Heparin 5000 U/ml	mdwyxbgcvl(mzeyrpyukc) = hysahrocus jpbmckuaxs (fgunonaqld )
Pubmed \| Am J Kidney Dis	Not Applicable	-	-	Sodium Citrate	humdgqdvoj(kpyzacarex) = chvearsjdh bsrdzccurk (xesmtgqtyu ) View more	-	01 Jun 2009
				Heparin	humdgqdvoj(kpyzacarex) = xteofkbdhw bsrdzccurk (xesmtgqtyu ) View more