The aim of this study is to prospectively evaluate a novel sinus rhythm mapping strategy for ventricular tachycardia (VT) ablation based on combined ventricular repolarization and activation (depolarization) mapping (REpolarization DEpolarization Mapping, REDEEM mapping). Furthermore, gathering clinical data on VT ablation with TactiFlex is also aimed.

Start Date01 Jun 2025

Sponsor / Collaborator

Universitair Ziekenhuis Brussel

NCT05891899

/ Not yet recruitingNot ApplicableIIT

Antithrombin Registry - Investigation of Phenotype-genotype Correlations in Patients With Inherited Antithrombin Deficiency

Inherited antithrombin deficiency is a rare autosomal dominant disorder that predisposes to the development of venous thromboembolism, even at young age.
Inherited AT deficiency is considered the most severe form of inherited thrombophilia, increasing up to 40 times the risk of venous thrombosis.
Our center has been performing research on antithrombin deficiency for several years. Therefore, it was decided to initiate a registry for patients with inherited antithrombin deficiency with the goal to gain more insight into what drives the development of a thrombotic event in patients with AT deficiency, both at the environmental level (lifestyle, management of risk situations, presence of additional thrombotic risk factors...) and at the genetic level.

Start Date01 May 2025

Sponsor / Collaborator

Universitair Ziekenhuis Brussel

NCT06629155

/ Not yet recruitingNot ApplicableIIT

Disentangling Cognitive Functioning and Visual Scanning Deficits in Cognitive Test Results in Multiple Sclerosis (MS)

The goal of this observational study is to study the relationship between cognitive problems and problems in eye movements in Multiple Sclerosis (MS).
The main questions it aims to answer are:
* What is the correlation between eye movement parameters (VDI AUC and VDI Pv/Am, left and right) and SDMT scores in patients with MS?
* What is the number of patients with VDI AUC>1.174 and/or VDI Pv/Am>1.180 assessed by infrared oculography during prosaccades at 15 degrees left or right?
* What is the correlation between eye movement parameters (VDI AUC and VDI Pv/Am, left and right) and cognitive test scores in patients with MS?
Participants will perform specific cognitive tests and eye movements will be measured through infrared oculography.
The primary hypothesis for the study is: participants who exceed the treshold (VDI AUC>1.174 and/or VDI Pv/Am>1.180, left or right) will perform worse on cognitive tests compared to those who don't.

Start Date01 Mar 2025

Sponsor / Collaborator

Universitair Ziekenhuis Brussel

100 Clinical Results associated with Universitair Ziekenhuis Brussel

0 Patents (Medical) associated with Universitair Ziekenhuis Brussel

2,421

Literatures (Medical) associated with Universitair Ziekenhuis Brussel

01 Mar 2025·Behavioural Brain Research

Baseline gray matter volume associates with working memory performance after prefrontal transcranial direct current stimulation

Article

Author: Vanderhasselt, Marie-Anne ; De Smet, Stefanie ; da Silva, Pedro Henrique Rodrigues ; Razza, Lais B ; Martin-Garcia, Oscar ; Brunoni, Andre R ; De Witte, Sara

Working memory is crucial for daily life and is often impaired in neuropsychiatric conditions. Attempts to enhance it using transcranial direct current stimulation (tDCS) have shown mixed results, possibly due to large inter-individual variability. This study assessed whether baseline regional brain volume was associated with working memory performance following tDCS. Healthy participants were randomly assigned to three bilateral tDCS protocols (sham, 1.5 mA, and 3 mA) over the dorsolateral prefrontal cortex (dlPFC) (anode-left, cathode-right) for 20 minutes, in a within-subjects design with a 2-week interval, followed by emotional and non-emotional 3-back tasks. Baseline volumetric data were used to extract gray matter volumes of defined regions of interest; the dlPFC, the medial PFC (mPFC), and the posterior cingulate cortex (PCC) bilaterally. Data from thirty-nine participants (69.2 % female, mean age: 24.56 years) across 112 tDCS sessions were analyzed. Findings revealed no significant association between working memory performance post sham-tDCS and gray matter volume. However, larger baseline cortical volumes across all regions were associated with slower reaction times and lower accuracy for the non-emotional task at 1.5 mA, whereas non-significant results were observed at 3 mA. For the emotional task, only a significant association for reaction time after 3 mA and left dlPFC and right PCC were found. Findings highlight not only the association between individual baseline gray matter, but also the impact of methodological choices, such as current intensity and outcome, on the effect of tDCS. Future research should aim to further explore individual variability and methodological factors to deepen our understanding of the mechanisms underlying tDCS.

01 Feb 2025·European Journal of Cancer

Addressing the role of surgery in brain tumour trials: A report from the neurosurgery committee of the EORTC brain tumour group

Article

Author: Neidert, Marian ; Preusser, Matthias ; Karschnia, Philipp ; Gorlia, Thierry ; Jakola, Asgeir S ; Le Rhun, Emilie ; Goldbrunner, Roland ; Weller, Michael ; Gempt, Jens ; Broekman, Marike ; Petrescu, George E D ; Quoilin, Caroline ; Minniti, Giuseppe ; Widhalm, Georg ; Duerinck, Johnny ; Picart, Thiebaud ; Grossman, Rachel ; Jenkinson, Michael D

The Brain Tumor Group (BTG) of the European Organization for Research and Treatment of Cancer (EORTC) conducts academic clinical trials and translational research to improve clinical management of patients with primary and secondary brain tumors. The EORTC BTG has traditionally played an important role in providing evidence and thus advancing the field, albeit with a main focus on radiotherapy and pharmacotherapy in gliomas. Although examples of well-designed neuro-oncological surgical trials can be found, evidence in surgical neuro-oncology predominantly includes data from uncontrolled prospective series or retrospective cohorts. By means of a thorough literature and EORTC database review, we demonstrate, firstly, that while the pathway of the neuro-oncology patient most often starts with neurosurgery, its several aspects have traditionally been poorly acknowledged in clinical trials in neuro-oncology. We also show that the definitions and methods of assessment vary greatly between studies, limiting generalizability. The newly established Neurosurgery Committee of the EORTC BTG aims to address this gap by increasing the number of prospective surgical trials, but also the involvement of neurosurgeons in clinical trial design, promoting standardized terminology for description of the surgical aspects, including extent of resection. We will also explore alternative trial designs when randomization is deemed difficult, as well as focus on defining surgical quality indicators that influence outcome. By addressing these challenges, the committee aims to enhance the quality of neurosurgical evidence in neuro-oncology and define optimal surgical methods and standards of care. This should ultimately improve outcomes and quality of life for patients with brain tumors through evidence-based surgical interventions.

01 Feb 2025·Computer Methods and Programs in Biomedicine

CTGAN-driven synthetic data generation: A multidisciplinary, expert-guided approach (TIMA)

Article

Author: Parise, Orlando ; La Meir, Mark ; Parise, Gianmarco ; de Asmundis, Carlo ; Kronenberger, Rani ; Gelsomino, Sandro

OBJECTIVEWe generated synthetic data starting from a population of two hundred thirty-eight adults SARS-CoV-2 positive patients admitted to the University Hospital of Brussels, Belgium, in 2020, utilizing a Conditional Tabular Generative Adversarial Network (CTGAN)-based technique with the aim of testing the performance, representativeness, realism, novelty, and diversity of synthetic data generated from a small patient sample. A Multidisciplinary Approach (TIMA) incorporates active participation from a medical team throughout the various stages of this process.METHODSThe TIMA committee scrutinized data for inconsistencies, implementing stringent rules for variables unlearned by the system. A sensitivity analysis determined 100,000 epochs, leading to the generation of 10,000 synthetic data. The model's performance was tested using a general-purpose dataset, comparing real and synthetic data.RESULTSOutcomes indicate the robustness of our model, with an average contingency score of 0.94 across variable pairs in synthetic and real data. Continuous variables exhibited a median correlation similarity score of 0.97. Novelty received a top score of 1. Principal Component Analysis (PCA) on synthetic values demonstrated diversity, as no patient pair displayed a zero or close-to-zero value distance. Remarkably, the TIMA committee's evaluation revealed that synthetic data was recognized as authentic by nearly 100%.CONCLUSIONSOur trained model exhibited commendable performance, yielding high representativeness in the synthetic dataset compared to the original. The synthetic dataset proved realistic, boasting elevated levels of novelty and diversity.

100 Deals associated with Universitair Ziekenhuis Brussel

100 Translational Medicine associated with Universitair Ziekenhuis Brussel

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

68GaNOTA-Anti-MMR-VHH2(Universitair Ziekenhuis Brussel) ( CD206 )	Non-Small Cell Lung Cancer More	Phase 2
TriMixDC-MEL	Melanoma More	Phase 2
Ipilimumab ( CTLA4 )	Recurrent Glioblastoma More	Phase 1
Trimix(eTheRNA Immunotherapies)	Early Stage Breast Carcinoma More	Phase 1
Autologous CD1c (BDCA-1)+ myDC(Universitair Ziekenhuis Brussel)	Solid tumor More	Pending

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