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Disease Domain	Count

Neoplasms	4
Endocrinology and Metabolic Disease	3
Immune System Diseases	2
Infectious Diseases	2
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	9
Herbal medicine	3
Chemical drugs	2
Antibody	1
Monoclonal antibody	1

Top 5 Target	Count

F10 x prothrombin	1
BNIP3(BCL2 interacting protein 3)	1
CSF-1R(Colony stimulating factor 1 receptor)	1
RANKL(Tumor necrosis factor ligand superfamily member 11)	1
ASK1(Apoptosis signal-regulating kinase 1)	1

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute deterioration in the setting of chronic liver disease associated with high short-term mortality. Currently, there is no specific treatment for patients with ACLF. Our previous results showed that Chinese herbal medicine (CHM) could reduce the mortality rate and the incidence of complications of ACLF effectively. In this study, we aim to conduct the multi-center randomized controlled trial to evaluate the effect of unified CHM formulas and provide propagable and high-level evidence for clinical practice.
Methods/design: This is a prospective, multicenter, centrally randomized controlled trial. Five hundred and ten patients diagnosed with HBV-related ACLF will be allocated in a 1:1 ratio to SMT group (standard medical therapy) and CHM group (CHM and SMT). The primary outcome is the transplant-free mortality rates at week 4, 8, 12, 24 and 48. Secondary outcomes include (1) the incidence of adverse reactions, (2) influence on liver function, (3) the incidence of serious complications and (4) the level of inflammatory cytokines.
Discussion: The effectiveness and safety of CHM formulas are assessed in the treatment of ACLF.

Start Date10 Jan 2019

Sponsor / Collaborator

Huazhong University of Science & Technology

[+7]

ChiCTR1900021368

/ Not yet recruitingNot ApplicableIIT

The Diagnosis and Treatment of Rheumatoid Arthritis by Zhuang Medical Stereo Comprehensive Therapy: a randomized controlled trial

Start Date31 Jan 2018

Sponsor / Collaborator

Minzu University of China

[+1]

100 Clinical Results associated with Guangxi University of Chinese Medicine

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0 Patents (Medical) associated with Guangxi University of Chinese Medicine

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1,337

Literatures (Medical) associated with Guangxi University of Chinese Medicine

01 Aug 2026·COMPUTATIONAL BIOLOGY AND CHEMISTRY

Genetic basis of immune-mediated necrotizing myopathy: A genomic structural equation modeling and AI-driven structural analysis

Article

Author: He, Xinyu ; Wei, Jihu ; Lin, Zehong ; Chen, Yixin ; Zhou, Honghai

BACKGROUND:

Immune-mediated necrotizing myopathy (IMNM) constitutes an autoimmune myopathy precipitated by autoantibodies, marked by rapid progression and recurrent exacerbations, with no approved curative therapies currently available. Genetic determinants serve as pivotal etiological contributors; however, comprehensive genome-wide association study (GWAS) data elucidating IMNM's genetic architecture remain absent.

METHODS:

We implemented Genomic Structural Equation Modeling (Genomic SEM) to perform a large-scale multivariate GWAS, probing shared genetic architectures across traits to estimate single nucleotide polymorphisms (SNPs) associated with independent variant associations. Multiple transcriptome-wide association analyses were subsequently deployed to identify potential mediation loci with high IMNM correlation, spanning tissue stratifications, cellular hierarchies, and genomic annotations. AI modeling coupled with protein molecular dynamics simulations was then employed to decipher how such loci modulate protein structure and functional dynamics.

RESULTS:

This study integrated GWAS data from six phenotypes through a multi-scale approach and systematically analyzed 5049,276 common variants within the Genomic SEM framework. Using FUMA for functional annotation and independent filtering, we identified 128 statistically significant lead loci. These loci may mediate the genetic risk of IMNM through latent factor effects. Protein modeling and dynamics simulations demonstrated that mutations undermine protein structural stability and disrupt the poised balance of functional domain flexibility, thereby compromising functional protein expression.

CONCLUSIONS:

Our study pioneers a comprehensive genetic framework for IMNM by applying GWAS to an indirectly assessed phenotype, articulating a panoramic view of IMNM's hereditary landscape and the molecular mechanisms through which genetic variations govern disease pathology.

01 Apr 2026·JOURNAL OF ETHNOPHARMACOLOGY

Total flavonoids isolated from Fructus Mume (Prunus mume Sieb. et Zucc.) mitigate Parkinson's disease progression by promoting neuronal mitophagy via activation of the CaMKKβ/AMPK signaling pathway

Article

Author: Feng, Xiaotao ; Wen, Xiaodong ; Wang, Chunling ; Huang, Lizhen ; Lu, Xiangdong ; Zhang, Wentao ; Gao, Mengyuan ; Sun, Mengjie

ETHNOPHARMACOLOGICAL RELEVANCE:

Fructus Mume (FM) is derived from the nearly ripe fruit of Prunus mume Sieb. et Zucc., and widely used as a traditional medicine in Asian countries. FM has the effect of calming Liver to stop endogenous Wind, and has been used for thousands of years in the treatment of Parkinson's disease (PD), as recorded in ancient formulas such as Wumei Pills. However, the specific mechanism by which it treats PD remains larger unclear.

PURPOSE:

The aim of this study was to investigate the effects and mechanisms by which the active ingredients of FM (Fructus Mume flavonoids, FMF) mitigate the progression of PD.

METHODS:

We isolated FMF from FM and explored its chemical composition and active compound content. In vivo and in vitro PD models were employed to investigate the alleviative effects of FMF on PD and its underlying mechanisms.

RESULTS:

We identified 193 compounds and quantified 154 flavonoid compounds in the FMF. Six compounds were present at concentrations exceeding 100 μg/g, namely Isorhamnetin (1287.0639 μg/g), Narcissin (764.9639 μg/g), Nicotiflorin (613.8568 μg/g), Quercetin (435.5215 μg/g), Nepitrin (295.4833 μg/g), and Kaempferol (241.9767 μg/g). Moreover, FMF alleviated behavioral deficits in PD rats. FMF also inhibited the loss of neurons and the formation of α-synuclein aggregates, and promoted the expression of tyrosine hydroxylase in the substantia nigra pars compacta in PD rats. In vivo and in vitro PD models demonstrated that autophagy inhibition significantly abolished the neuroprotective effects of FMF. Mechanically, FMF could enhance mitophagy to attenuate the mitochondrial dysfunction by activating the Ca²⁺/calmodulin-dependent protein kinase kinase β (CaMKKβ)/AMP-activated protein kinase (AMPK) signaling pathway.

CONCLUSION:

FMF promotes neuronal mitophagy to exert the neuroprotective effects by activating the CaMKKβ/AMPK signaling pathway. These findings provide a theoretical foundation for the application of FM in the treatment of PD and promote the clinical application of FM.

01 Mar 2026·CHEMISTRY & BIODIVERSITY

Two New Steroid Derivatives From the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 41325.

Article

Author: Liu, Yonghong ; Shen, Sijia ; Chen, Yushi ; Deng, Shengyi ; Song, Yingying ; Pang, Xiaoyan ; Xiao, Jiao ; Wang, Junfeng ; Zhang, Weijia

Two new steroid derivatives, 3-oxoergosta-4,6,8(14),22-tetraen-27-oic acid (1) and (14R,24R)-14-methyl-24,25-dihydroxycholesta-4,8-dien-3-one (2), together with one anthraquinone (3), one amino acid derivative (4), five cyclic dipeptides (5-9) and a quinazolinone alkaloid (10), were isolated from a deep-sea-derived Aspergillus versicolor SCSIO 41325. Notably, compound 2 features an unreported cholesta-4,8-dien-3-one steroid scaffold among natural products. The structures were determined by NMR and high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) spectroscopic methods, single-crystal x-ray diffraction measurements and comparison with literature data. All isolated compounds were subjected to a broad range of biological assays, including tests against pathogenic bacteria and fungi, as well as for inhibition of pancreatic lipase, acetylcholinesterase, neuraminidase, and antioxidant activity evaluations.

100 Deals associated with Guangxi University of Chinese Medicine

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100 Translational Medicine associated with Guangxi University of Chinese Medicine

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Pipeline

Pipeline Snapshot as of 19 Mar 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

4

11

Preclinical

IND Approval

1

Phase 2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Zhideke Granules	Tracheobronchitis More	Phase 2
Bawei Longzuan Granules	Rheumatoid Arthritis More	IND Approval
K3G ( Notch-1 )	Allergic asthma More	Preclinical
Mangiferin ( glucokinase )	Alzheimer Disease More	Preclinical
Lychee Peel Extract	Hyperuricemia More	Preclinical