Tianjin Institute of Pharmaceutical Research Co., Ltd.

Regulatory filing with China’s National Medical Products Administration requests approval for Jublia for treatment of onychomycosis, a fungal toenail infection. San Diego, CA, USA – March 9, 2021 – HUYABIO International (HUYABIO), the leader in accelerating global development of China’s pharmaceutical innovations, today announced that its joint venture with Tianjin Institute of Pharmaceutical Research has submitted a New Drug Application to the Chinese National Medical Products Administration’s Center for Drug Evaluation. The joint venture, AIM, was established with the intent of advancing innovative medicines. The application requests approval of a topical formulation of the antifungal drug, efinaconazole, as Jublia™, for the treatment of onychomycosis. Jublia is the first triazole-based topical formulation approved for the treatment of onychomycosis, a common and destructive fungal infection of the toenails. Other topical treatments lack efficacy and oral treatments are limited by drug interactions and serious safety concerns. Jublia is considered the treatment of choice for patients with mild to moderate cases or who cannot tolerate oral treatments. This drug is already approved in Japan, the United States, Canada, Korea, Taiwan, Hong Kong and Macau, where it is sold under the brand names Clenafin™ or Jublia. AIM licensed exclusive rights in China from the originator company, Kaken Pharmaceuticals, in February 2019.1 Dr. Mireille Gillings, CEO & Executive Chair of HUYABIO, said, “This submission represents an important milestone for HUYABIO and AIM as we work with partners such as Kaken to bring products to the Chinese market. Jublia addresses a significant need as an effective topical treatment for onychomycosis and a promising alternative to more toxic systemic therapies. We plan additional regulatory filings in the future.” About AIM AIM is a joint venture between HUYABIO International and the Tianjin Institute of Pharmaceutical Research. AIM identifies and evaluates medical opportunities from outside of China. The joint venture utilizes the Tianjin Institute of Pharmaceutical Research’s infrastructure in China and HUYABIO’s global network to accelerate the development of products for the China market. About HUYABIO International HUYABIO is the leader in accelerating the global development of novel biopharmaceutical product opportunities originating in China enabling faster, more cost-effective and lower-risk drug development global markets. Through extensive collaboration with biopharmaceutical, academic and commercial organizations, it has built the largest China-sourced compound portfolio covering all therapeutic areas. With offices in the US, Japan, South Korea, Canada, Ireland and eight strategic locations across China, the company has become a partner of choice to accelerate product development and maximize value globally. Contact Details: Bob Goodenow, PhD President +1.858.342.2430 bgoodenow@huyabio.com Yiota Merianos Corporate Communications 1.858.353.1217 ymerianos@huyabio.com 1http://www.kaken.co.jp/english/en_release/license-and-distribution-agreement-for-clenafin-jublia-in-peoples-republic-of-china.html

San Diego, CA, USA – January 18, 2012 — HUYA Bioscience International today announced a strategic partnership agreement with the Tianjin Institute of Pharmaceutical Research (TIPR). HUYA is a leader in globalizing China’s biopharmaceutical innovations and TIPR is one of the leading pharmaceutical research institutes in China. The collaborative agreement will combine both parties‘ strengths in promoting the advancement of China’s drug innovations. HUYA is one of the first companies to have recognized China’s potential to meet the global need for new drug compounds. Through a series of strategic collaborations with leading universities and research institutions in China, HUYA has pioneered a co- development model of identifying and licensing promising preclinical and early clinical stage compounds from China, utilizing its expertise to advance these compounds for global development. Through this, HUYA facilitates and promotes the global development and commercialization of novel pharmaceutical products originating in China. The Tianjin Institute of Pharmaceutical Research is among the oldest and most prestigious research institutions in China. It was originally established by the State Food and Drug Administration in 1959, and is now a wholly state-owned organization, focusing on new drug innovation and development. With substantial experience in both western and traditional Chinese medicine development, TIPR has positioned itself as a major force in drug innovation and development in China. In addition to its many basic research and educational facilities, TIPR also includes a number of pharmaceutical manufacturing enterprises which allow it to see a drug candidate from the early discovery stage all the way though clinical trials. Under the agreement, HUYA and TIPR will collaborate to promote new drug development in China and worldwide. HUYA will have the first opportunity to evaluate certain research and development projects conducted at TIPR, and to provide support and assistance as needed. With its unique co-development model and worldwide pharmaceutical partners, HUYA will help globalize select programs from TIPR. “The Tianjin Institute of Pharmaceutical Research is exactly the kind of top-level partner we are seeking in China,” said Clement Gingras, HUYA’s CTO and COO, China. “This partnership is an honor and we are looking forward to working together to accelerate innovative drug development in China.” Dr. Lida Tang, president of TIPR, believes a strategic partnership with HUYA can help take TIPR-developed compounds to the next level in development, testing, and commercialization. “There is no doubt we have the scientific basis to come up with novel drug compounds. With HUYA we now have the international expertise to make a global impact.” About HUYA Bioscience International HUYA is a leader in global pharmaceutical co-development with Chinese partners. With eight offices strategically located across China, the most comprehensive Chinese compound portfolio in the world, and a rapidly growing number of exclusive agreements with premier Chinese research and development organizations, HUYA occupies a unique position with regards to the China bio-pharmaceutical industry. HUYA’s strategy is to identify and license novel Chinese compounds and to offer Western pharmaceutical companies efficient and comprehensive access to innovative therapeutic opportunities. HUYA’s experience with this market means it can dramatically reduce deal-making complexity in China. HUYA has become a champion of guiding China’s biomedical innovations to the worldwide marketplace. HUYA is jointly headquartered in San Diego, CA and in Shanghai. Additional information is available at www.huyabio.com. About Tianjin Institute of Pharmaceutical Research (TIPR) TIPR is located in the northern Chinese industrial powerhouse of Tianjin, 69 miles east of Beijing. Tianjin is the sixth-largest city in China and is one of four cities in China under the direct administration of the central government. Its new city, known as Binhai New Area, is a rapidly developing industrial zone with an annual growth rate of nearly 30%. TIPR itself consists of seven major research divisions, including a center for drug innovation, a Medicinal Chemistry Department, a Traditional Chinese Medicine Department, a Center for Pharmaceutical Formulation Technology and Engineering Support and a Center for Drug Evaluation. In recent years TIPR has been engaged in over 100 special projects of key novel drug innovations designated as national priorities. It has also received over 200 new drug certificates, including small molecules, Chinese medicines and biological drugs. Additional information is available at www.tjipr.com. Contact USA: Yung-Chih Wang, Ph.D., MBA Vice President, Corporate Development China HUYA Bioscience International +1.858.798.8800 ywang@huyabio.com China: Ping Yang, MS Business Development Manager HUYA Bioscience International +86.10.5805.1907 pyang@huyabio.com