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Disease Domain	Count

Nervous System Diseases	10
Infectious Diseases	8
Immune System Diseases	7
Endocrinology and Metabolic Disease	4
Hemic and Lymphatic Diseases	2

Top 5 Drug Type	Count

Herbal medicine	34
Small molecule drug	2

Top 5 Target	Count

PDE4 x TGF-β1 x TNF	1
TNF(Tumor necrosis factor)	1
Cu x HIF-1α	1
motilin	1

To investigate the inhibitory effect of Glycyrrhiza uralensis (G. uralensis) and its monomeric compounds on Nav1.4 voltage-gated sodium channels (VGSCs) and analyze the relationship between the content of its marker compounds and the inhibitory rate. Based on this study, we found that 4 mg/ml ethanol extract of G. uralensis at 30%, 50%, 70% and 90% (v/v) exhibited 77.00 ± 0.03%, 34.75 ± 0.09%, 100.00 ± 0.01% and 2.00 ± 0.01% inhibitory rates on I_Nav1.4 respectively, and 8 mg/ml ethanol extract of G. uralensis at 30%, 50%, 70% and 90% (v/v) exhibited 99.00 ± 0.01%, 97.10 ± 0.02%, 100.00 ± 0.01% and 17.00 ± 0.04% inhibitory rates on I_Nav1.4 respectively. Isoliquiritigenin, echinatin, liquiritin and glycyrrhizic acid exhibited higher inhibitory rates of 39.98 ± 4.55%, 33.20 ± 1.61%, 22.62 ± 0.30% and 20.54 ± 4.82% respectively. However, liquiritigenin, formononetin, neoisoliquiritin and glycyrrhetinic acid exhibited lower inhibitory rates of less than 20%. Further, liquiritin apioside, isoliquiritin and neoliquiritin exhibited almost no effect on I_Nav1.4. These findings showed that glycyrrhizic acid reached a maximum concentration of 49.15 μg/ml, while echinatin had the lowest concentration. The ethanol extract of G. uralensis has significant inhibitory effects on Nav1.4 VGSCs. This may be an important mechanism in the treatment of gastrocnemius spasm and could guide further research regarding material basis and mechanism of the treatment of gastrocnemius spasm with peony and licorice decoction.

01 Sep 2017·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research on technology regulation of non-polluted cultivation and strategies of Panax ginseng cultivation in farmland].

Article

Author: Dong, Lin-Lin ; Li, Xi-Wen ; Xu, Jiang ; Naoli, Fujihara ; Zhang, Nai-Wu ; Chen, Shi-Lin ; Shen, Liang

As the limit of the usage of available forest land, cultivated ginseng in the farmland would become the mainly Panax ginseng planting mode, meanwhile the non-polluted production technology would be the mainly development direction in the future. In this study, the non-polluted cultivation technology system of P. ginseng was established based on the research results of field investigation in the cultivated regions. The system includes suitable planting regions selecting, planting method, field management, pest control, harvesting & processing, and quality control. Aimed at the serious issues in the cultivation, research strategies have been provided to guarantee the sustainable development of the ginseng industry. The patterns of soil restoration after P. ginseng cultivation, establishment the platform of comprehensive disease & pest control, breeding new varieties for high stress tolerance and resistance, and a traceability system for P. ginseng cultivation. In all, these strategies was considered to largely developing of the ginseng industry in the green and sustainable way.

01 Mar 2017·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Soil improvement promoted micro-ecology of farmlands for ginseng cultivation].

Article

Author: Li, Xi-Wen ; Chen, Shi-Lin ; Dong, Lin-Lin ; Shen, Liang ; Xu, Jiang ; Zhang, Nai-Wu ; Niu, Wei-Hao ; Wang, Rui ; Naoki, Fujiwara

This study has revealed the change of the soil micro-ecology of farmlands, which used for ginseng cultivation, brought by comprehensive soil improvement. The process of soil improvement was described as follows： soil was sterilized using trichloronitromethane, and then perilla seeds were planted. After growing up, the perillas were turned over into the field and fermented, then organic fertilizer was added. Rotary tillages were carried out during the intervals. Physical and chemical properties of treated soil were measured, as well as microbial diversity, which was illustrated using 16s high through-put sequencing. The survival rate and growth data of ginseng seedlings were recorded. The analysis showed that after improvement, the soil organic matter content was increased and soil bulk density was decreased, compare to the controls, and the fertility in 0-20 cm of soil layer was increased in the treatment. Additionally, the soil microbial diversity was changed greatly. In detail, alpha diversity of the soil decreased after soil improvement while the beta diversity increased. In order to verify the achievement of soil improvement, ginseng seedlings were planted. Compared to the untreated land blocks, the survival rate of ginseng on improved blocks was increased up to 21.4%, and the ginseng physiological index were all better than the controls. Results showed that comprehensive soil improvements including soil sterilization, green manure planting and organic fertilization application effectively improved the soil micro-ecology in farmlands. This study will pave the way for the future standardization of ginseng cultivation on farmlands.

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Pipeline

Pipeline Snapshot as of 05 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

35

Approved

Other

13

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Niuche Shenqi Pills	Dysuria More	Approved
Chai Ling Decoction	Tumescence More	Approved
Qingshu Yiqi Decoction	Diarrhea More	Approved
Trientine Hydrochloride ( Cu x HIF-1α )	Hepatolenticular Degeneration More	Approved
Danggui Jianzhong Decoction	Hemorrhoids More	Approved