The objective of this study was to determine the comparative pharmacoki-netics, safety and tolerability of test formulation Dasatinib tablets 140 mg with reference formulation Sprycel 140 mg filmtabletten after single dose administration under fasting conditions in 24 healthy adult male and female volunteers.This was an open label, two periods, two treatments, two-way crossover, controlled, block randomized, bioequivalence study in male and female, healthy volunteers, under fasting conditions.Each subject received a Dasatinib tablets 140 mg of test and reference product in each period re-spectively.Blood samples were collected before dosing and at various time points up to 24 h after drug administration.A total of 20 subjects re-ceived one dose of Dasatinib tablets 140 mg (TEST) or one dose of SPRYCEL 140 mg Filmtabletten (Reference) in two different occa-sions separated by a wash-out period of 16 days.Twenty eight (28) adverse events of mild and moderate intensity occurred in fourteen subjects in the study.These were not serious adverse events and the volunteers completely recovered before the end of the study.The statistical anal. of the phar-macokinetic data obtained in this study shows that the two Dasatinib formu-lations, Dasatinib tablets 140 mg of MSN Laboratories Pvt.Ltd., India - TEST and SPRYCEL 140 mg Filmtabletten, formulation of BRISTOL-MYERS SQUIBB PHARMA EEIG, United Kingdom - Reference are not bioequivalent, in fasting conditions.The Dasatinib Tablets 140 mg treatments (TEST and Reference), administered in single dose, orally, to male and female healthy volunteers, in fasting conditions were well tol-erated by all the subjects in this study.