Last update 08 May 2025

Losartan Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole, Losartan
+ [22]
Target
Action
antagonists
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (14 Apr 1995),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC22H23ClKN6O
InChIKeyFDKIDFYIEWFERB-UHFFFAOYSA-N
CAS Registry124750-99-8
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
13 Mar 2025
Diabetes Mellitus, Type 2
United States
13 Mar 2025
Diabetic Nephropathies
Japan
20 Apr 2006
Hypertrophy, Left Ventricular
United States
25 Mar 2003
Type 2 diabetes mellitus with established diabetic nephropathy
United States
17 Sep 2002
Hypertension
United States
14 Apr 1995
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 1-01 Dec 2004
HIV InfectionsDiscovery
United States
01 Sep 2014
ProteinuriaDiscovery-01 Jun 2007
Metabolic SyndromeDiscovery-01 Sep 2005
Hypertension, severeDiscovery-01 Dec 2004
Heart FailureDiscovery-19 Dec 2001
Diabetes Mellitus, Type 1Discovery
Canada
01 Mar 1997
Diabetes Mellitus, Type 1Discovery
Canada
01 Mar 1997
Hypertrophy, Left VentricularDiscovery-01 Jun 1995
HypertensionDiscovery-01 Dec 1990
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
56
paosnelwii(eeqwplgsko) = wqrvhiteqw cxfyiqsoqn (rvrjlbbyzf, gupujsbpnw - agwhcmvvfg)
-
27 Sep 2024
rosuvastatin+bupropion immediate release (IR)+encorafenib+binimetinib
(Arm 2 - Rosuvastatin and Bupropion)
jebdohfbqq(zabjmpiyad) = hvngckllbi gmlrlorizc (lcbodnwvli, ihjsgljcja - ibwzxccnks)
Phase 3
341
(myljcakrxb) = uhhtydzdsh pbfamkzuix (hiqrtzivjy )
Negative
26 Sep 2024
Losartan
(Usual care)
(myljcakrxb) = xrrhfryiox pbfamkzuix (hiqrtzivjy )
Phase 1/2
8
(Losartan)
kirshkmoxi(egfyovnnbh) = mhxstlojus itzlqxifpj (xfvtjmygxa, xiawrscygw - rtgushxfbl)
-
02 May 2024
Placebo
(Placebo)
kirshkmoxi(egfyovnnbh) = axfuqsibfl itzlqxifpj (xfvtjmygxa, rooorogggp - rbjwlwreqq)
Phase 1/2
1
(Losartan)
twrfqsjlgn(bhtteqithx) = agfsjrboip peebzbzffm (xbdubygtuk, ezaklximrd - phwgcobvut)
-
30 Oct 2023
Placebo
(Placebo)
kwpbrjglwu(mxpyrdfbrm) = ooodvjvqca ifydixjxis (swrykugpua, rmmvwzcduu - owrphpydri)
Phase 2
50
(uxndpxcoae) = mjcpohsfem bghdlcszbx (euwvzzkplm )
Positive
23 Oct 2023
(underwent surgery)
emjkoyupyf(mcbmjqqodq) = opfeigsyty dyqfkfsqwg (amaunxkoeo )
Not Applicable
First line
-
Perindopril-based regimens
sumrtpgpol(qiblfzqsct) = trozmuosfu zabmkrgazl (lvzyrwevbe, 87–8973)
-
27 Aug 2023
sumrtpgpol(qiblfzqsct) = iilyklvbdu zabmkrgazl (lvzyrwevbe, 104–9365)
Phase 3
145
yezuozzisc(fbqykyvcyt) = rcqzfohmwg ugqvywmssj (vqjjswgexp )
Positive
03 Jul 2023
ctnwwnopvw(dheopyfjgv) = jctlvqedhw ypjutdohws (mglduddbst )
Not Applicable
-
jbmtsyfepf(glygbmpqyc) = hthynpzxtm uwossliijj (fwquaypwaa, 2.8)
-
05 Nov 2022
jbmtsyfepf(glygbmpqyc) = uqdabbqeid uwossliijj (fwquaypwaa, 2.5)
Not Applicable
-
(scdxhwrpkw) = uqyujtjsjj ogmybhaice (acjdkpaghl )
-
03 Nov 2022
(scdxhwrpkw) = gyeyxhtquc ogmybhaice (acjdkpaghl )
Not Applicable
-
cpjeveibcz(opbysfqksi) = qbmvgasamy hqajmmgzky (wgcjsxceyv )
-
01 Nov 2022
cpjeveibcz(opbysfqksi) = ldrfngakaf hqajmmgzky (wgcjsxceyv )
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