China Resources Double-Crane Pharmaceutical (Jinan) Co., Ltd.

The aim of this study was to investigate the pharmacokinetic characteristics of a single oral dose of the test formulation (T) upadacitinib extended-release tablets (strength: 15 mg as calculated in C17H19F3N6O) and the reference formulation (R) upadacitinib extended-release tablets (strength: 15 mg as calculated in C17H19F3N6O) in the fasting state, and to compare the differences in the absorption rate and extent of the test formulation and the reference formulation in healthy participants.

Primary objective: To compare the differences in the extent and rate of absorption of carbidopa sustained-release tablets (specification: 50 mg carbidopa and 200 mg levodopa per tablet) provided by China Resources Double Crane Limin Pharmaceutical (Jinan) Co., Ltd. and carbidopa sustained-release tablets (specification: 50 mg carbidopa and 200 mg levodopa per tablet; trade name: Sinemet®/Xining®) certified by MSD Sharp & Dohme GmbH in healthy subjects under fasting and fed conditions. Secondary objective: To evaluate the safety and tolerability of carbidopa sustained-release tablets (specification: 50 mg carbidopa and 200 mg levodopa per tablet) provided by China Resources Double Crane Limin Pharmaceutical (Jinan) Co., Ltd. and carbidopa sustained-release tablets (specification: 50 mg carbidopa and 200 mg levodopa per tablet; trade name: Sinemet®/Xining®) certified by MSD Sharp & Dohme GmbH under fasting and fed conditions.

The purpose of this study was to investigate the pharmacokinetic characteristics of a single oral administration of the test formulation T polypreg zinc orally disintegrating tablets (strength: 75 mg) and the reference formulation R polypreg zinc orally disintegrating tablets (strength: 75 mg; trade name: Promac® D) in the fasting and fed states, to compare the differences in absorption rate and extent between the test formulation and the reference formulation in healthy study participants, and to evaluate the palatability of polypreg zinc orally disintegrating tablets in healthy Chinese participants in the fasting study, so as to provide a basis for the taste of polypreg zinc orally disintegrating tablets.