Delving into the Latest Updates on Pregabalin with Synapse

Overview

Basic Info

SummaryPregabalin, commonly referred to as Lyrica®, is a well-known anticonvulsant medication, which has found its footing in the treatment of various medical conditions. Such conditions include but are not limited to anxiety disorders, epilepsy, and neuralgia. The mechanism of action that characterizes pregabalin's utility involves blocking the CACNA2D1 and CACNA2D2 calcium channels, thus effectively targeting these disorders with aplomb. The Upjohn Co. received approval for the medical use of pregabalin in the European Union as far back as 2004, indicating that the medication has been a key feature of medical treatment for some time. Pregabalin's indications primarily target the treatment of neuropathic pain conditions, including fibromyalgia, and partial onset seizures in combination with other anticonvulsant medications. These conditions are managed with pregabalin due to its efficacy in minimizing their attendant symptoms. Pregabalin, therefore, serves as a vital tool in the management of chronic pain and neurological disorders.

Drug Type

Small molecule drug

Synonyms

LYRICA CR

+ [10]

Target

CACNA2D1 x CACNA2D2

Action

blockers

Mechanism

CACNA2D1 blockers(Voltage-gated calcium channel alpha2/delta subunit 1 blockers), CACNA2D2 blockers(Voltage-gated calcium channel alpha2/delta subunit 2 blockers)

Therapeutic Areas

Immune System DiseasesNervous System DiseasesEndocrinology and Metabolic Disease+ [2]

Active Indication

FibromyalgiaSeizuresNeuralgia, Postherpetic+ [7]

Inactive Indication

Acute herpes zoster neuropathyBreast CancerComplex Regional Pain Syndromes+ [30]

Originator Organization

The Upjohn Co.

Active Organization

Huizhi Pharmaceutical (Dalian) Co., Ltd.

Pfizer Inc.

Zentiva ks

+ [16]

Inactive Organization

Pfizer GmbH

Viatris, Inc.

John Hunter Hospital

+ [6]

License Organization

Chongqing Succeway Pharmaceutical Co., Ltd.

Coland Pharmaceutical Co., Ltd.

Viatris, Inc.

+ [3]

Drug Highest PhaseApproved

First Approval Date

European Union (05 Jul 2004),

Epilepsies, PartialEpilepsyGeneralized anxiety disorder+ [1]

RegulationSpecial Review Project (China), Priority Review (China)

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Structure/Sequence

Molecular FormulaC8H17NO2

InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-N

CAS Registry148553-50-8

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants with painful peripheral neuropathy.
The analgesic effect is evaluated by measuring pain intensity and Patient Global Impression of Change (PGIC).
This study is a 3-period cross-over trial. This means researchers will compare 3 different drugs (pregabalin, duloxetine, and placebo) over a period of 19 weeks.
Participants will:
* Undergo a quantitative sensory testing (QST) exam.
* Provide a blood sample.
* Complete questionnaires on the computer.
* Take the study drug as instructed.

Start Date01 Sep 2025

Sponsor / Collaborator

University of Rochester

[+1]

CTRI/2025/04/084123

/ Not yet recruitingPhase 2/3IIT

Evaluation of efficacy and safety of add-on Pregabalin and olanzapine versus add-on aprepitant to dexamethasone and ondansetron in preventing chemotherapy-induced nausea and vomiting: A randomized, double-blind, active-controlled, group-sequential and non-inferiority clinical trial - NIL

Start Date01 Jun 2025

Sponsor / Collaborator-

100 Clinical Results associated with Pregabalin

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100 Translational Medicine associated with Pregabalin

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100 Patents (Medical) associated with Pregabalin

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6,606

Literatures (Medical) associated with Pregabalin

01 Dec 2025·Current Pain and Headache Reports

Acupuncture for the Management of Chronic Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Review

Author: Busse, Jason W ; Couban, Rachel J ; Ma, Wenbin ; Liu, Yunyu ; Sadeghirad, Behnam ; Wang, Li ; Tang, Juan ; Lan, Lei

AIMDiabetic peripheral neuropathy (DPN) affects up to half of all patients with diabetes mellitus. Acupuncture is often used to manage chronic pain, but its' effects on DPN are uncertain. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) to assess the effectiveness of acupuncture for DPN.METHODSWe searched databases from inception to September 30, 2024. Paired reviewers independently extracted data and assessed risk of bias. We used random effects models for all meta-analyses and the GRADE approach to assess the certainty of evidence.RESULTSWe included 14 RCTs (1,169 participants, 45% female). Low certainty evidence suggests that, compared to sham, acupuncture may reduce pain (weighted mean difference [WMD] -1.44 cm on a 10 cm VAS, 95%CI -1.72 to -1.15; modelled risk difference [RD] for achieving the minimally important difference [MID] of 1.5 cm: 45%, 95%CI 35-54%). Comparted to sham or usual care, low certainty evidence suggests that acupuncture may reduce overall neurological symptom severity (WMD - 1.22 [95%CI -1.85, -0.59] on the 19-point Toronto Clinical Scoring System [TCSS]), and provide little to no difference in physical functioning, mental functioning, or adverse events. Low certainty evidence suggests that, compared to amitriptyline or pregabalin, acupuncture may reduce pain associated with DPN.CONCLUSIONSAcupuncture for DPN may reduce pain when compared to sham acupuncture and may reduce neurologic symptom severity and result in little to no difference in physical functioning, mental functioning or adverse events, when compared with sham acupuncture or usual care.

01 Aug 2025·Neuropharmacology

Aripiprazole: The antiallodynic and antihyperalgesic effects in chronic constriction injury-induced neuropathic pain and reserpine-induced fibromyalgia with possible mechanisms

Article

Author: Aykaç, Özlem ; Okcay, Yagmur ; Bektas, Nurcan ; Arslan, Rana

Neuropathic pain, caused by peripheral or central nerve damage, and fibromyalgia, a chronic musculoskeletal disorder, require complex treatment approaches. This study evaluated the antiallodynic and antihyperalgesic effects of aripiprazole (1, 5, and 10 mg/kg, i. p.) in rats with chronic constriction injury-induced neuropathic pain and reserpine-induced fibromyalgia in female Sprague-Dawley rats, using electronic von Frey and Hargreaves tests. Dopaminergic, serotonergic, and opioidergic systems' roles were assessed through pre-treatment with sulpiride (50 mg/kg), WAY 100635 (1 mg/kg), and naloxone (1 mg/kg), respectively. The effect of aripiprazole was compared with 30 mg/kg pregabalin in the neuropathic pain model and 30 mg/kg duloxetine in the fibromyalgia model. Aripiprazole demonstrated significant antiallodynic and antihyperalgesic activity in both models. It did not change locomotor activity at a dose of 1 mg/kg but caused a decrease at a dose of 5 mg/kg. Dopamine D₂, serotonin 5-HT_1A, and opioidergic receptors contributed to aripiprazole's effects at varying levels. This study highlights the potential use of aripiprazole for managing neuropathic pain and fibromyalgia by targeting multiple receptor systems. The findings demonstrate the potential use of aripiprazole alone or as an adjuvant in the treatments of neuropathic pain and fibromyalgia.

01 Jun 2025·Current Pharmaceutical Design

Untargeted Metabolomics and Bioactivities Assessment of Xylaria ellisii, an Endophytic Fungus Isolated from the Leaf of the Plant Acorus calamus Linn.

Article

Author: Garg, Neha ; Rai, Sachchida Nand ; Singh, Santosh Kumar ; Rajak, Naina ; Singh, Anurag Kumar ; Prajapati, Chandrabhan

Introduction:Fungal endophytes have mutualistic associations with the plant's host, communicating through genetic and metabolic processes. As a result, they gain the ability to generate therapeutically effective metabolites and their derivatives.Methods:The current study aims to assess antioxidant potential along with the identification of robust metabolites within the crude extract of a potent endophytic fungus Xylaria ellisii isolated from leaf tissues of the Acorus calamus Linn. plant. Four endophytic fungi were obtained from leaf tissues of Acorus calamus Linn., and identified morphologically and molecularly as distinct species. Each ethyl acetate extract of the isolated fungi exhibited a unique chemical profile in the HPTLC fingerprint at various wavelengths. The ethyl acetate (EA) extract from the fungal strain ACL-4 (Xylaria ellisii) demonstrated the strongest antioxidant activity among the four fungal endophytes examined, with an EC50 value of 292.64 ± 3.558 μg/mL. Remarkably, fungal endophyte ACL-4 extract exhibited superior antimicrobial activity at the less concentrations compared to ACL-ME extract of leaf crude.Results:The extract of ACL-ME-treated HEK 293T cells exhibited significant toxicity, with an IC50 value of 1481.74 ± 23.772 μg/mL, compared to fungal strain ACL-4-treated HEK 293T cells, which had an IC50 value greater than 2000 μg/mL. Consequently, the crude extract of ACL-4 and ACL-ME along with the standard drug methotrexate exhibited cytotoxic activity against cancer cell line MDA-MB-231 with IC50 concentrations of 146.65 ± 0.394 μg/mL, 528.46 ± 10.912 μg/mL, and 134.11 ± 3.446 μg/mL, respectively. A total of 2,255 compounds were detected through LC-HRMS-based metabolomics in the crude metabolites of Xylaria ellisii, with certain compounds identified in multiple instances. Among this repertoire, 62 robust bioactive compounds were identified through meticulous screening, guided by existing literature. Comparative HPTLC fingerprint analysis, along with antioxidant efficacy assays of ethyl acetate extracts of Xylaria ellisii derived from Acorus calamus leaves and Cassia fistula twigs revealed the host-specific production of bioactive chemicals.Conclusion:The top-scoring Keap1 inhibitors derived from Xylaria ellisii, including Pregabalin (-6.083 Kcal/mol), Ferulic acid (-5.434 Kcal/mol), (R)-Piperidine-2-carboxylic acid (-5.31 Kcal/mol), Genipin (-5.197 Kcal/mol), and Brivaracetam (-5.17 Kcal/mol), respectively were considered as Keap 1 inhibitors, potentially mitigate oxidative stress.

91

News (Medical) associated with Pregabalin

07 Mar 2025

·endpts.com

Start of 2025 comes with generic drug price decreases, several major increases, report finds

More generic drug prices decreased than increased in January, a new report from 46Brooklyn found. The report said for every generic drug price increase in January, 1.3 generic drugs saw their price decrease. It’s a trend that 46Brooklyn CEO Antonio Ciaccia called “a largely favorable view.” Even still, three generic drugs saw their prices increase significantly, including the nerve pain drug pregabalin ER 165 mg (26% increase), the nausea drug dronabinol 10 mg (21% increase), and the ADHD drug methylphenidate CD 30 mg (18% increase). For branded drugs, Chiesi’s Ferriprox and Harrow’s Verkazia both increased by more than 20%, although brand-name increases are largely restricted by a Medicaid program that forces pharma companies to pay rebate penalties for drug price increases greater than the rate of inflation. There were 963 net brand price increases in January, according to the report, which was largely in line with the 896 net brand price increases in January 2024 and 986 price increases in January 2023. A previous analysis from Ciaccia’s consultancy firm 3 Axis Advisors anticipated price hikes to more than 1,000 medicines. The report from 46Brooklyn also highlights several key brand-name drug increases that could cost Medicaid significantly more than what they were paying in previous years. For instance, J&J’s Stelara saw a nearly 5% list price increase, which works out to about $1.5 billion in gross prior-year Medicaid expenditures. Several biosimilars to Stelara recently launched at prices as low as 90% off the brand-name price. Chiesi raised the list price of its enzyme replacement therapy Revcovi by 4.5% in January. The report noted that the average gross cost per prescription in Medicaid for this drug is roughly $200,000, which means the list price increase “is anticipated to add roughly $9K in gross cost per prescription. This is the highest added gross cost per Rx for the brand drugs that took price increases in January 2025.” Chiesi did not immediately respond to a request for comment. In addition to the 46Brooklyn report, Sanofi released a report earlier this week on its pricing principles , showing the French company in 2024 spent 36% of its gross sales to payers as rebates. And UCB also released its own pricing report this week showing that 54% of its 2024 gross sales were provided to supply chain stakeholders, including private and public payers as rebates, discounts and fees.

Biosimilar

19 Dec 2024

·www.accesswire.com

MIRA Pharmaceuticals Submits IND for Ketamir-2 to FDA, Marking a Significant Milestone in the Company's Pipeline Development

MIAMI, FL / ACCESSWIRE / December 19, 2024 / MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA), a preclinical-stage pharmaceutical company focused on developing therapies for neurological and neuropsychiatric disorders, today announced that it has submitted an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) for Ketamir-2, its novel oral ketamine analog for the treatment of neuropathic pain. The IND submission marks a major step in advancing Mira's lead drug candidate while reflecting its commitment to meeting milestones and timelines.Erez Aminov, Chairman & CEO of Mira, stated: "This IND submission highlights our team's commitment to executing efficiently as we advance transformative therapies. Ketamir-2 not only has demonstrated remarkable potential for neuropathic pain but also offers a broad opportunity across other major neuropsychiatric conditions. We look forward to beginning Phase I trials and continuing to deliver on our mission to address unmet medical needs."The IND application includes comprehensive data and reports detailing Ketamir-2's pharmacology, pharmacokinetics, and toxicology, along with results from both in vitro and in vivo studies, including validated neuropathic pain disease models. In parallel with the submission, the company is preparing to conduct a complementary neurotoxicity study, as required by the FDA's written feedback to the pre-IND documentation.According to a market analysis report from Fortune Business Insights, the neuropathic pain market in North America, including the United States, Canada, and Mexico, is valued at $3.1 billion and is expected to grow at a 6-7% compound annual growth rate (CAGR), reaching $4.5 billion by 2030. Despite this growth, existing treatments remain inadequate. Gabapentin and pregabalin, while widely prescribed, provide limited efficacy and are associated with side effects such as sedation, dizziness, and weight gain. Opioids remain a common treatment option but come with well-known risks of dependency, addiction, and respiratory depression. Intravenous ketamine, though effective for some patients, requires invasive administration and is often associated with psychotropic side effects, including hallucinations and dissociation.Ketamir-2 is specifically designed to address the limitations of existing treatments through its selective targeting of the NMDA receptor. By binding to a specific site on the NMDA receptor with low affinity, Ketamir-2 significantly reduces the risk of psychotropic effects commonly associated with traditional ketamine. Furthermore, it is not a substrate for P-glycoprotein (P-gp), which allows for better oral absorption and enhanced blood-brain barrier penetration. Unlike traditional ketamine, Ketamir-2 does not cause sedation or hyperactivity-side effects often linked to psychiatric conditions such as schizophrenia, bipolar mania, and ADHD. As a non-opioid therapy, Ketamir-2 is designed to eliminate the risks of dependency and addiction. Additionally, the DEA has determined that Ketamir-2 is not a controlled substance, streamlining accessibility and minimizing regulatory hurdles.Preclinical studies have demonstrated Ketamir-2's ability to achieve 100% pain reversal, fully normalizing pain thresholds in validated neuropathic pain models. Furthermore, Ketamir-2 has shown a strong safety and toxicological profile, observed across cardiovascular, CNS, respiratory, or toxicology assessments.Dr. Itzchak Angel, Chief Scientific Advisor at Mira, commented: "Ketamir-2's selective mechanism of action, strong safety profile, and ability to achieve full pain reversal underscore its potential as a transformative therapy."With the IND submitted, MIRA expects to initiate Phase I Clinical Trials in Q1 2025 to evaluate safety, tolerability, pharmacokinetics and pharmacodynamics in healthy volunteers. Phase IIa trials are expected to follow in late 2025 to assess efficacy in neuropathic pain patients. Beyond neuropathic pain, the company is exploring additional indications for Ketamir-2, including MDD, MDD-SI, TRD and PTSD.About MIRA Pharmaceuticals, Inc.MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA) is a pre-clinical-stage pharmaceutical development company with two neuroscience programs targeting a broad range of neurologic and neuropsychiatric disorders. MIRA holds the exclusive U.S., Canadian, and Mexican rights for Ketamir-2, a novel, patent-pending oral ketamine analog under investigation to treat neuropathic pain (NP), treatment-resistant depression (TRD), major depressive disorder with suicidal ideation (MDD-SI), and post-traumatic stress disorder (PTSD).MIRA's novel oral pharmaceutical marijuana analog, MIRA-55, is currently under investigation for treating adult patients suffering from anxiety and cognitive decline, often associated with early-stage dementia. If approved by the FDA, MIRA-55 could mark a significant advancement in addressing various neuropsychiatric, inflammatory, and neurologic diseases and disorders.The U.S. Drug Enforcement Administration's scientific review concluded that both Ketamir-2 and MIRA-55 would not be considered controlled substances or listed chemicals under the Controlled Substances Act and its governing regulations.Additional information about MIRA Pharmaceuticals is available at www.mirapharmaceuticals.com.Cautionary Note Regarding Forward-Looking StatementsThis press release and the statements of MIRA Pharmaceuticals' (or the "Company") management related thereto contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will," and variations of these words or similar expressions that are intended to identify forward-looking statements. Any statements in this press release that are not historical facts may be deemed forward-looking. These forward-looking statements include, without limitation, statements regarding the anticipated benefits of the study results described herein as well as the timing for the Company's other preclinical studies and the filing of an IND for Ketamir-2. Any forward-looking statements in this press release are based on the Company's current expectations, estimates, and projections only as of the date of this release and are subject to a number of risks and uncertainties (many of which are beyond the Company's control) that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These and other risks concerning the Company's programs and operations are described in additional detail in the Annual Report on Form 10-K for the year ended December 31, 2023, and other SEC filings, which are on file with the SEC at www.sec.gov and the Company's website at https://www.mirapharmaceuticals.com/investors/sec-filings. The Company explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.Contact InformationHelga Moya [email protected](786) 432-9792SOURCE: Mira Pharmaceuticals, Inc.

Phase 1Phase 2IND

02 Dec 2024

·www.drugs.com

Guidelines Developed for Treatment of Restless Legs Syndrome

MONDAY, Dec. 2, 2024 -- In a clinical practice guideline issued by the American Academy of Sleep Medicine and published online Sept. 26 in the Journal of Clinical Sleep Medicine , recommendations are presented for the treatment of restless legs syndrome (RLS). John W. Winkelman, M.D., Ph.D., from Massachusetts General Hospital in Boston, and colleagues developed recommendations for treatment of RLS and periodic limb movement disorder in adults and pediatric patients. The researchers developed three good practice statements that were based on expert consensus. They recommend all clinicians should regularly test serum iron studies, including ferritin and transferrin saturation, in all patients with clinically significant RLS, ideally in the morning; analysis of these studies influences the decision to use oral or intravenous (IV) iron treatment. The authors also state that addressing exacerbating factors, including alcohol, caffeine, antihistaminergic, serotonergic, and anti-dopaminergic medications, should be the first step in RLS management. They note RLS is common in pregnancy and the pregnancy-specific safety profile of each treatment should be considered. Recommendations for adults with RLS include use of gabapentin enacarbil over no gabapentin enacarbil; use of gabapentin over no gabapentin; use of pregabalin over no pregabalin; and use of IV ferric carboxymaltose over no IV ferric carboxymaltose for those with appropriate iron status (strong recommendations; moderate certainty of evidence). In addition, there is a strong recommendation against use of cabergoline. "Guided by the best evidence in the scientific literature, we've provided recommendations that will improve the ability of clinicians to provide patient-centered care for people who have RLS," Winkelman said in a statement. One author disclosed ties to the pharmaceutical and medical device industries. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

100 Deals associated with Pregabalin

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External Link

KEGG	Wiki	ATC	Drug Bank
D02716	Pregabalin	N03AX16	DB00230

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Fibromyalgia	United States	Upjohn US 2 LLC	21 Jun 2007
Seizures	Australia	Viatris Pty Ltd.	13 Apr 2005
Neuralgia, Postherpetic	United States	CP Pharmaceuticals Ltd.	30 Dec 2004
Epilepsies, Partial	Norway	Upjohn EESV	05 Jul 2004
Epilepsies, Partial	Iceland	Upjohn EESV	05 Jul 2004
Epilepsies, Partial	European Union	Upjohn EESV	05 Jul 2004
Epilepsies, Partial	Liechtenstein	Upjohn EESV	05 Jul 2004
Epilepsy	Iceland	Upjohn EESV	05 Jul 2004
Epilepsy	Norway	Upjohn EESV	05 Jul 2004
Epilepsy	Liechtenstein	Upjohn EESV	05 Jul 2004
Epilepsy	European Union	Upjohn EESV	05 Jul 2004
Generalized anxiety disorder	Norway	Upjohn EESV	05 Jul 2004
Generalized anxiety disorder	Iceland	Upjohn EESV	05 Jul 2004
Generalized anxiety disorder	Liechtenstein	Upjohn EESV	05 Jul 2004
Generalized anxiety disorder	European Union	Upjohn EESV	05 Jul 2004
Neuralgia	Norway	Upjohn EESV	05 Jul 2004
Neuralgia	Iceland	Upjohn EESV	05 Jul 2004
Neuralgia	European Union	Upjohn EESV	05 Jul 2004
Neuralgia	Liechtenstein	Upjohn EESV	05 Jul 2004

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Epilepsy	Phase 1	European Union	MyLan SAS	25 Jun 2015
Epilepsy	Phase 1	Iceland	MyLan SAS	25 Jun 2015
Epilepsy	Discovery	Iceland	MyLan SAS	25 Jun 2015
Epilepsy	Discovery	European Union	MyLan SAS	25 Jun 2015
Diabetic peripheral neuropathy	Discovery	United States	Pfizer Inc.	30 Dec 2004
Neuralgia, Postherpetic	Discovery	United States	Pfizer Inc.	30 Dec 2004

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05974501 (CTgov)	Phase 4	complications of arthroplasty \| Osteoarthritis, Knee \| Pain, Postoperative	84	Lyrica+Ropivacaine+Acetaminophen+Oxycodone+Celebrex+Meloxicam+Dexamethasone (Preoperative Adductor Canal Block Group)	sdbvgotbzh(zxkqlowryi) = xaxdyrvjfn mmwejdipoc (exkttpzwfd, uyaxonfpir - rvpgbadeht) View more	-	12 Feb 2025
				Lyrica+Ropivacaine+Acetaminophen+Oxycodone+Celebrex+Meloxicam+Dexamethasone (Postoperative Adductor Canal Block Group)	sdbvgotbzh(zxkqlowryi) = gpwqlpjrdh mmwejdipoc (exkttpzwfd, skjhtiopaz - lqplysujlr) View more
NCT04122196 (CTgov)	Phase 2/3	Kidney Calculi \| Pain, Postoperative	118	Pregabalin 300mg (Pregabalin 300mg)	lezwfwzzou(jnxqgzoqwq) = gvyajygsjy bjlabyutud (stgejvzbqu, ejstaotlhd - xmhjblmxrs) View more	-	24 Oct 2024
				Placebo oral tablet (Placebo)	lezwfwzzou(jnxqgzoqwq) = okbthvgejd bjlabyutud (stgejvzbqu, hkwqbjrlfa - zlncjecork) View more
NCT04015908 (CTgov)	Phase 4	-	100	Pregabalin+Acetaminophen+Celecoxib+Oxycodone (Multi-modal)	bzvvubqjov(xvpttrkrep) = swckoohfda meiuvvwhma (cfwnzdhupu, uxmijtkjyb - lepqwjatym) View more	-	08 Jul 2024
				Percocet (Control)	bzvvubqjov(xvpttrkrep) = dhxxovhcmy meiuvvwhma (cfwnzdhupu, uhgaxhqyzv - yufpekkuyt) View more
NCT04218240 (PGB-LOF, CTgov)	Phase 2	Opioid abuse	90	Pregabalin 200 MG capsules+Lofexidine 0.18Mg Tab (PGB/LFX;)	sicutaqnss(aynucdwxwc) = vqdxqoipsh ihtwpmgcgn (xqnnsqtucb, oitesbeiql - sevppmhivk) View more	-	20 May 2024
				Placebo oral tablet+Lofexidine 0.18Mg Tab (Lofexidine and PLACEBO)	sicutaqnss(aynucdwxwc) = lrfweuathm ihtwpmgcgn (xqnnsqtucb, cjjflrskfg - pjzzghtuoi) View more
NCT02884908 (CTgov)	Phase 3	Alcohol Use Disorder \| Stress Disorders, Post-Traumatic	57	BBCET+Pregabalin (Pregabalin + BBCET)	ftzitkxbaj(slvzjjhnyi) = eqtgokcdyd dngshdzxil (cegoozubfc, qrfjbbvwme - teinkoltrl) View more	-	13 Mar 2024
				Placebo (Placebo + BBCET)	ftzitkxbaj(slvzjjhnyi) = ukqvwzsred dngshdzxil (cegoozubfc, ijirdyinok - gpcpoykoyh) View more
ESMO_ASIA2023	Not Applicable	Add-on	84	Olanzapine 5 mg plus pregabalin 75 mg	dwxzfbmqcu(yliaqidayv) = sfsytwnejh jmodiylhod (rxhjrofgln )	-	02 Dec 2023
				Placebo	dwxzfbmqcu(yliaqidayv) = ohpdhbkjdl jmodiylhod (rxhjrofgln )
NCT00310765 (CTgov)	Phase 4	Abdominal Pain \| Tissue Adhesions \| Surgical Adhesion	18	pregabalin+placebo (Patients Treated With Placebo)	fspzrzgtfu(ayaeihjqrb) = whispmjtkh sihkrnwtzy (evojvmkeqb, wkdpkrxlqq - flrimemiln) View more	-	23 Oct 2023
				Pregabalin (Patients Treated With Pregabalin)	fspzrzgtfu(ayaeihjqrb) = omexacrbuj sihkrnwtzy (evojvmkeqb, hwpldomuov - dkkeycdurr) View more
NCT04246619 (BLOSSOM, Pubmed)	Phase 4	Diabetic peripheral neuropathic pain	254	Pregabalin	(bgmhyslmrq) = kcqrgqutso qppzvsesnz (vbglojakhm, [ - 41.4, to 32.6]) View more	Positive	18 Jul 2023
				Duloxetine	(bgmhyslmrq) = aepvsoyvce qppzvsesnz (vbglojakhm, [ - 41.5, to 32.3]) View more
EULAR2023	Not Applicable	Cancer Pain	-	Pregabalin	vlzqmiyfzf(sppcfltpyc) = txgqjwcghp zvvhrloozv (czguqgyjwv )	Negative	31 May 2023
				Gabapentin	vlzqmiyfzf(sppcfltpyc) = ipzjiupyzl zvvhrloozv (czguqgyjwv )
NCT01801189 (CTgov)	Phase 4	Pain, Postoperative	61	pregabalin (Pregabalin)	ivrvuoobtg(xbjfkqgsvs) = rwzfwpzkba clnszbhtfw (hhwcssatpd, ixbihqwrlt - ewitooiaql) View more	-	06 Jun 2022
				Placebo (for Pregabalin) (Sugar Pill)	ivrvuoobtg(xbjfkqgsvs) = nmlulggwhj clnszbhtfw (hhwcssatpd, wlsbhaoctk - mnzbqajvad) View more