[Translation] A single-center, randomized, double-blind, placebo-controlled, single-dose ascending study to evaluate the safety, tolerability, pharmacokinetics and pharmacokinetics of SYH2053 injection in Chinese participants with normal or elevated low-density lipoprotein cholesterol Phase I clinical trials of pharmacodynamic characteristics
主要目的:评价SYH2053注射液在中国不同LDL-C血清浓度水平参与者中单次皮下注射给药的安全性和耐受性;
次要目的:评价SYH2053注射液在中国不同LDL-C血清浓度水平参与者中单次皮下注射给药的PK、PD特征以及对QT/QTc间期的影响
探索性目的:评价SYH2053注射液在中国不同LDL-C血清浓度水平参与者中单次皮下注射给药后探索性生物标志物表达水平的变化特征;评价SYH2053注射液在中国不同LDL-C血清浓度水平参与者中单次皮下注射给药的免疫原性特征
[Translation] Main purpose: To evaluate the safety and tolerability of a single subcutaneous injection of SYH2053 injection in Chinese participants with different LDL-C serum concentration levels;
Secondary purpose: To evaluate the PK and PD characteristics of SYH2053 injection administered as a single subcutaneous injection and its effect on QT/QTc interval in Chinese participants with different LDL-C serum concentration levels
Exploratory purpose: To evaluate the changing characteristics of exploratory biomarker expression levels after a single subcutaneous injection of SYH2053 injection in Chinese participants with different LDL-C serum concentration levels; to evaluate the changes in exploratory biomarker expression levels of SYH2053 injection in Chinese participants with different LDL-C serum concentrations. Immunogenicity Characteristics of Single Subcutaneous Injection Administration in Level Participants