Jilin Province Deshang Pharmaceutical Co., Ltd.

Main purpose of study: According to the provisions of relevant bioequivalence test, Telmisartan Amlodipine Tablets (trade name: Twynsta, specification: 80mg/5mg) with Boehringer Ingelheim International GmbH as the licensee was selected as the reference preparation, and the test preparation Telmisartan Amlodipine Tablets (specification: 80mg/5mg) produced and licensed by Jilin Deshang Pharmaceutical Co., Ltd. was subjected to human bioequivalence test on fasting and postprandial administration, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting and postprandial administration conditions. Secondary purpose of study: To observe the safety of oral administration of the test preparation Telmisartan Amlodipine Tablets (specification: 80mg/5mg) and the reference preparation Telmisartan Amlodipine Tablets (trade name: Twynsta, specification: 80mg/5mg) by healthy volunteers.

Main purpose of study: According to the relevant provisions of bioequivalence test, Olmesartan medoxomil orodisintegrating tablets (trade name: Olmetec: specification: 20mg) of Daiichi Sankyo Pharmaceutical Co., Ltd. was selected as the reference preparation, and the test preparation Olmesartan medoxomil orodisintegrating tablets (specification: 20mg) produced by Jilin Deshang Pharmaceutical Co., Ltd. was conducted on the fasting and postprandial human bioequivalence test, to compare whether the absorption rate and degree of the drug in the test preparation are within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting and postprandial administration conditions. Secondary purpose of study: To observe the safety of oral administration of the test preparation Olmesartan medoxomil orodisintegrating tablets (specification: 20mg) and the reference preparation Olmesartan medoxomil orodisintegrating tablets (trade name: Olmetec: specification: 20mg) by healthy volunteers.

According to the relevant provisions of bioequivalence tests, the reference preparation was selected as Ezetimibe Atorvastatin Calcium Tablets (trade name: Atozet®, specification: 10mg/10mg) produced by Organon Healthcare GmbH, and the test preparation Ezetimibe Atorvastatin Calcium Tablets (specification: 10mg/10mg) produced by Jilin Deshang Pharmaceutical Co., Ltd. and provided by Beijing Mange Pharmaceutical Technology Co., Ltd. was used for fasting and postprandial human bioequivalence preliminary test to evaluate the pharmacokinetic characteristics of the two preparations and provide a reference for the formal test design. At the same time, the safety of healthy subjects after oral administration of the test preparation and the reference preparation was observed.