[Translation] A single-dose, open-label phase I clinical trial comparing the pharmacokinetics, safety, and pharmacodynamics of HRS-1301 tablets in subjects with mild, moderate, and severe renal impairment and healthy subjects.
主要目的:评价并比较HRS-1301在轻、中、重度肾功能不全受试者和健康受试者中的药代动力学(PK)特征。
次要目的:评价HRS-1301在轻、中、重度肾功能不全受试者和健康受试者中的其他PK特征、安全性、药效学(PD)特征。
[Translation] Primary objective: To evaluate and compare the pharmacokinetic (PK) characteristics of HRS-1301 in subjects with mild, moderate, and severe renal impairment and healthy subjects.
Secondary objective: To evaluate other PK characteristics, safety, and pharmacodynamic (PD) characteristics of HRS-1301 in subjects with mild, moderate, and severe renal impairment and healthy subjects.