Q2 · MEDICINE
Article
Author: Marzinke, Mark ; Pearson, Elizabeth ; Su, Jonathan T. ; Tfaily, Ewa Bryndza ; Widanapathirana, Lakmini ; Grasperge, Brooke ; Peet, M. Melissa ; Sung, Samuel ; Cain, Charlette M. ; Veazey, Ronald ; Simpson, Solange M. ; Dobek, Georgina ; Qiu, Jiang ; Kiser, Patrick F. ; Watrous, David ; Hope, Thomas ; Karunakaran, Dipu
We describe the
in vitro
and
in vivo
evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug for over 90 days
in vitro
and
in vivo
. We evaluated the implants for implantation site histopathology and pharmacokinetics in plasma and tissues for up to 12 weeks in New Zealand White rabbit and rhesus macaque models.