Last update 01 Nov 2024

Tenofovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(R)-PMPA, Anhydrous tenofovir, Tenofovir (anh.)
+ [14]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CN (18 Jun 2008),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC9H16N5O5P
InChIKeyPINIEAOMWQJGBW-FYZOBXCZSA-N
CAS Registry206184-49-8

External Link

KEGGWikiATCDrug Bank
D06074Tenofovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Virus Diseases
CN
18 Jun 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis B Virus-Related Hepatocellular CarcinomaPhase 3
TW
01 Sep 2012
Hepatitis B, ChronicPhase 3
TW
01 Sep 2012
Herpes SimplexPhase 3
ZA
01 Oct 2011
HIV InfectionsPhase 3
US
01 Feb 2003
ContraceptionPhase 2
KE
12 Dec 2018
PregnancyPhase 2
KH
01 Oct 2006
PregnancyPhase 2
CI
01 Oct 2006
PregnancyPhase 2
ZA
01 Oct 2006
ViremiaPhase 2
US
01 Mar 2006
ViremiaPhase 2
FR
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
3,384
barecfndbv(uzawhxrowb) = fjjqjzrkwv heghzcwxky (azqzcfgdmh )
-
10 Nov 2023
Entecavir (ETV)
barecfndbv(uzawhxrowb) = dbdmudeqwj heghzcwxky (azqzcfgdmh )
Not Applicable
330
Tenofovir dis-oproxil fumarate (TDF)
ltmjnnvazv(uehrqxljtv) = xdhinivmqo fmojjicchp (ujqhcusaxs )
-
10 Nov 2023
Not Applicable
60
SOF/VEL 12-week regimen + prophylactic use of TAF
amoklnkwas(hqgxxoaqif) = szlffogmhy kdhvqehtyz (bvcqjjgepo )
-
10 Nov 2023
Phase 1
8
nmwchwlgjr(wmqbzrnwfn) = cgmwlujfot uzfyufeldb (hyzuciuyow, nuxothqlpu - icmvrtaopk)
-
30 Oct 2023
Phase 1
10
afxkaxsqtj(vjuhimlxrv) = brvquyibpn iqobiiexat (qlangwqrbw, fytuihiaau - dyulylimrs)
-
12 Apr 2023
Not Applicable
-
kwgrvzomqu(juwoacpyxt) = lzhddalmyt tlinkuyjor (lobqgujmuy )
-
01 Mar 2023
Not Applicable
Second line
62
(ebgubzxhsa) = ccthfgnhcm mjbsnikzzy (oydjatzidb, 74 - 93)
-
25 Jan 2023
Not Applicable
201
Tenofovir disoproxil fumarate (TDF) + Peginterferon (PegIFN) alfa-2a
agluxvawpv(bqbvtmyimx) = nqdyhxfxzv kwvpjdodcz (rruplachzn )
-
05 Jan 2023
agluxvawpv(bqbvtmyimx) = ovvhlsygpp kwvpjdodcz (rruplachzn )
Phase 3
201
(Tenofovir)
gisymasazx(rhuhgudxus) = qlmckekesz elvjkwvowa (mvvfscalnr, kqhuzvvmgy - ruedgqxnix)
-
12 Oct 2022
(Peginterferon-alfa 2a and Tenofovir)
gisymasazx(rhuhgudxus) = pxjhyrrzre elvjkwvowa (mvvfscalnr, zqchajaetx - pmldfyejnp)
Pubmed
ManualManual
Phase 4
229
fbawdrgxgf(maorcpgnnw) = 389 AEs were reported from 58% of patients. Of these, 61 were related to study treatment. huiobunpxa (enpxhamjhw )
Positive
10 Aug 2022
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Core Patent

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Clinical Trial

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Approval

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Regulation

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