Beijing TCR CURE Biopharma Technology Co., Ltd

Acquisition provides access to next-generation T-cell receptor therapies with promising potential for targeting solid tumours LONDON, UK I November 29, 2022 I AstraZeneca today announced an agreement to acquire Neogene Therapeutics Inc. (Neogene), a global clinical-stage biotechnology company pioneering the discovery, development and manufacturing of next-generation T-cell receptor therapies (TCR-Ts) that offer a novel cell therapy approach for targeting cancer. With a shared goal of bringing cell therapies to patients with solid tumours, Neogene’s expertise in TCR-T discovery, development and manufacturing will strengthen AstraZeneca’s ambition to transform outcomes for patients. TCR-Ts are emerging as a promising therapeutic modality in cancer treatment. Most current cell therapy approaches in oncology focus on modifying the immune system’s T cells to recognise proteins expressed on the surface of cancer cells. In contrast, TCR-Ts can recognise intracellular targets, including cancer-specific mutations, thereby potentially unlocking targets previously inaccessible using cell therapies. Susan Galbraith, Executive Vice President, Oncology R&D, AstraZeneca, said: “This acquisition represents a unique opportunity to bring innovative science and leading experts in T-cell receptor biology and cell therapy manufacturing together with our internal oncology cell therapy team, unlocking new ways to target cancer. Neogene’s leading TCR discovery capabilities and extensive manufacturing experience complement the cell therapy capability we have built over the last three years and allow us to accelerate the development of potentially curative cell therapies for the benefit of patients.” Carsten Linnemann, PhD, Chief Executive Officer, Neogene, said: “We are excited to work together with AstraZeneca towards our shared mission of transforming the treatment options for patients with solid tumours using next-generation T-cell receptor therapies. Our expertise, clinical portfolio and platform technologies in this area combined with AstraZeneca’s leadership in oncology and global footprint mean we are well-positioned to translate pioneering science into novel treatments for hard-to-treat cancers.” Neogene will operate as a wholly owned subsidiary of AstraZeneca, with operations in Amsterdam, the Netherlands and California, US. Financial considerations AstraZeneca will acquire all outstanding equity of Neogene for a total consideration of up to $320m, on a cash and debt free basis. This will include an initial payment of $200m on deal closing, and a further up to $120m in both contingent milestones-based and non-contingent consideration. The transaction is expected to close in the first quarter of 2023, subject to customary closing conditions and regulatory clearances. The transaction does not impact AstraZeneca’s financial guidance for 2022. Notes Neogene Therapeutics Neogene Therapeutics, Inc. is a global biotechnology company focused on discovering, developing and manufacturing next-generation, transformative TCR therapies targeting neoantigens in solid cancers. Neogene is advancing a pipeline of fully individualized TCR therapies as well as TCR therapies targeting shared neoantigens, including mutated KRAS (mKRAS) and mutated TP53 (mTP53). Neogene was founded by Carsten Linnemann, PhD, Chief Executive Officer of Neogene, and Ton Schumacher, PhD, Principal Investigator at the Netherlands Cancer Institute, Oncode Institute in partnership with Two River, and cell therapy industry veteran Arie Belldegrun, MD, founder of Kite Pharma, Inc. and Co-Founder and Executive Chairman of Allogene Therapeutics, Inc. as well as key investments from Vida Ventures, TPG, EcoR1 Capital, Jeito Capital, Syncona, Polaris Partners and Pontifax. Neogene has EU headquarters in Amsterdam and US headquarters in Santa Monica. Its team has deep gene and cell therapy expertise and a shared mission to bring next-generation transformative TCR therapies to patients with solid cancers worldwide. Please visit www.neogene.com and follow Neogene on LinkedIn . AstraZeneca in oncology cell therapy AstraZeneca is building a cell therapy portfolio that aims to empower and equip the immune system’s T cells to more effectively fight cancer. The Company is building on the work already done in blood cancers where chimeric antigen receptor T-cell (CAR-T) therapies, a type of living medicine created by isolating and modifying a patient’s T cells to target their specific tumour, are being used to treat some haematological malignancies. Their research teams are exploring new ways to target and arm CAR-Ts to increase their effectiveness in solid tumours by overcoming the immune-suppressive tumour microenvironment. Looking to the future, AstraZeneca is working to engineer next-generation cell therapies, where physicians could potentially select from a library of off-the-shelf patient-ready therapies already developed from the cells of healthy donors. Ultimately, by utilising innovative strategies to improve the precision and effectiveness of cell therapies, the Company’s goal is to deliver new medicines to help transform the lives of patients living with a range of cancers. AstraZeneca in oncology AstraZeneca is leading a revolution in oncology with the ambition to provide cures for cancer in every form, following the science to understand cancer and all its complexities to discover, develop and deliver life-changing medicines to patients. The Company’s focus is on some of the most challenging cancers. It is through persistent innovation that AstraZeneca has built one of the most diverse portfolios and pipelines in the industry, with the potential to catalyse changes in the practice of medicine and transform the patient experience. AstraZeneca has the vision to redefine cancer care and, one day, eliminate cancer as a cause of death. AstraZeneca AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @ AstraZeneca . SOURCE: AstraZeneca

Company strategy focused on developing differentiated TCR-T therapies from its proprietary “end-to-end” platform to target solid tumors with high unmet needPipeline expansion and acceleration of lead candidates with aim of advancing them into clinical developmentLead program, MDG1015, a TCR-T therapy for NY-ESO-1 combined with PD1-41BB Switch Receptor technology; at CTA /IND enabling phase, with submission planned for 2H 2024Second program, MDG10xx, TCR-T therapies for yet undisclosed targets combined with PD1-41BB Switch Receptor technology; candidate selection to be announced 2H 2023Additional technologies in development to enhance the “end-to-end” platformCurrent cash runway maintained into Q4 2024Management to host a conference call and webcast to discuss details of strategic update on Wednesday, November 16, 2022, at 3 pm CET MARTINSRIED, Germany and MUNICH, Germany, Nov. 15, 2022 (GLOBE NEWSWIRE) -- Medigene AG (Medigene, FSE: MDG1, Prime Standard), an immuno-oncology company focused on the development of differentiated, best-in-class T Cell Receptor engineered T cell (TCR-T) therapies, today announces an updated corporate strategy to drive and expedite the development of novel therapies for the treatment of multiple solid tumor indications with high unmet need. “We are excited to announce this strategy and corporate update for Medigene,” said Dr. Selwyn Ho, MB BS, Chief Executive Officer at Medigene. “At the heart of our work is our extensive expertise on T cell immunology and many years of development of a proprietary, innovative “end-to-end” platform under the leadership of our Chief Scientific Officer, Prof. Dolores Schendel. With the platform containing multiple combinable technologies that optimize the development of, as well as enhance the TCR-T products from both an activity and potential safety perspective, we believe that our emerging TCR-T therapies have the potential to address the significant challenges that solid tumors create for immunotherapies, and improve clinical outcomes. The robustness of our work has been well validated through multiple partnerships where potentially highly differentiated TCRs and novel individual technologies have been licensed from Medigene, as well as through the success of our MDG1011 phase 1 trial. We are focused on delivering best-in-class TCR-T therapies to patients suffering from difficult to treat tumors and have accelerated and prioritized our research activities. Our lead program, MDG1015, is a 3rd generation TCR-T therapy that combines a novel TCR against NY-ESO-1, a well-characterized and validated cancer antigen expressed in multiple tumor types, with the PD1-41BB Switch Receptor that significantly improves the ability of our TCR-T cells to kill cancer cells. This program has the potential for a more targeted, safer, and potent immune response while overcoming highly immunosuppressive tumor microenvironment. To support our efforts, we continue to strengthen our leadership team and have appointed Mr. James Cornicelli as Head of Corporate Development and Strategy. As a highly seasoned executive with over 20 years in senior business development and strategic advisory roles, Mr. Cornicelli brings multiple areas of expertise that will help guide our company on critical decisions about partnering and accelerate our growth strategy.” Strategic Actions Summary: TCR-T Therapies Central to Medigene’s Approach Medigene’s strategy will focus on developing best-in-class T Cell Receptor engineered T cell (TCR-T) therapies. TCR-T therapies are a novel class of cellular immunotherapy with the ability to engage both surface and intracellular antigens on target cells, unlike CAR-T cell-based therapies, allowing for solid tumor targeting in a highly specific manner. The first generation of TCR-T therapies have shown improvements in outcomes in solid tumor clinical trials; however, unmet needs remain for further improvements in efficacy, that are sustained and with a lower risk of adverse effects. Pipeline Expansion and Acceleration of Discovery Programs MDG1015 and MDG10xx MDG1015, the company’s lead program, consists of a novel TCR against NY-ESO-1 (New York esophageal squamous cell carcinoma 1), a well-characterized cancer testis antigen (CTA) expressed in multiple tumor types combined with our PD1-41BB Switch Receptor technology, which blocks the PD1/PD-L1 inhibitory axis between T cells and tumors and activates the 41BB co-stimulatory pathway in TCR-T cells. This co-stimulation and reduced inhibition, help mitigating the negative effects of the solid tumor microenvironment, leading to multiple improvements in the activity of MDG1015, including improved tumor cell killing, greater effector T cell function, and enhanced T cell proliferation. For MDG1015 we expect a CTA / IND filing in 2H 2024. MDG10xx is our second newly announced TCR-T therapy program against several undisclosed targets, in combination with the PD1-41BB Switch Receptor technology. The selection of a lead candidate for MDG10xx is planned for the second half of 2023. Advancing Broad, Proprietary “End-to-End” Platform Medigene’s “end-to-end” platform provides multiple combinable, exclusive, and proprietary technologies to create potential best-in-class TCR-T therapies to address the unmet needs in the treatment of solid tumors. The platform includes technologies that both help optimize our development activities as well as to enhance our TCR-T therapy products, during the stages of target screening, TCR generation, TCR-Therapy optimization, manufacturing, and clinical development. These include: EXPItope-M: Proprietary in silico tool to identify immunogenic epitopes as potential TCR target specificities.Allo-HLA TCR priming technology: Generation of high-affinity natural TCRs, for improved sensitivity and safety, by bypassing the thymic selectionCrossTAg vector system: Technology loads antigen on both HLA Class I and Class II complexes in antigen-presenting cells (APCs), creating stronger and more sustained immune responsesJOVI-Tag: Tool allowing standardized enrichment and tracking of recombinant TCR (rTCR) -expressing T cells to enable selection of safer TCRs when using HTSPD1-41BB Co-Stimulatory Switch Receptor: A novel, highly innovative receptor that enhances TCR-T cell functionality, enabling it to mitigate against immunosuppressive tumor microenvironment (TME) and improves efficacy and sustained immune responsesPrecision Pairing: Enables the modification and tailoring of TCR constant regions to improve pre-clinical efficacy through the enhanced anti-tumor functional activity of TCR-T cells and potential for improved safety by reducing the potential for off-target effectsInducible iM-TCR: Control mechanism to regulate TCR-T therapy efficacy & safety, to avoid T cell exhaustion, cell death, and a loss of efficacy as well as to prevent over-activation of TCR-T which can mediate inflammatory responses in off-target tissues Medigene is also currently developing additional novel and complementary technologies to add to our platform that will further optimize the development of and continue to enhance our TCR-T therapies. Strengthening & Expanding our Partnership Approach By Leveraging our Innovative Assets & Technologies To date, multiple partnerships have been established that validate our “end-to-end” platform assets and technologies, including with BioNTech, 2SeventyBio, and Hongsheng Sciences. Medigene will continue to work closely with our existing partners and explore new partnership opportunities to maximize the value of our current and future assets and technologies and ultimately deliver novel and differentiated TCR-T therapies to patients. Focus on Solid Tumors As previously announced, we have successfully completed our phase 1 MDG1011 program in patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and multiple myeloma (MM). The MDG1011 trial provides clear clinical validation of our ability to generate and manufacture TCR-T therapies and details of our manufacturing process have been shared at the Cell UK meeting in London, in November 2022 with the presentation available on Medigene’s website. The expanded clinical dataset from the trial will be available in due course. Despite this positive trial for MDG1011, as previously disclosed, we have focused any further research and development efforts towards solid tumors. The company is accelerating our plans to identify a suitable strategic partner and will provide an update in due course. Webcast on Updated Corporate Strategy The company will host a live conference call and webcast on its updated strategy on Wednesday, November 16, 2022, at 3 pm CET. A Q&A session will follow management’s formal presentation. A new corporate deck providing an overview of Medigene’s technologies, pipeline, and strategic vision can now be found here: https://www.medigene.com/investors-media/reports-presentations Full details for the webcast are as follows: Date: November 16, 2022Time: 3:00 pm Central European TimeU.S. Dial-in Number 1-877-451-6152Int'l Dial-in Number: 1-201-389-0879Conference ID: 13734186Webcast: Click Here Following the call, an archived webcast will also be accessible on the Investor & Media section of the Medigene Web site https://www.medigene.com/investors-media/reports-presentations About Medigene Medigene AG (FSE: MDG1) is a late pre-clinical stage immuno-oncology company, focusing on discovering and developing differentiated, breakthrough cellular therapies to improve the lives of cancer patients. With an end-to-end technology platform built on multiple proprietary and exclusive product enhancement and product development technologies, Medigene aims to create best-in-class TCR-modified T cell (TCR-T) therapies that are optimized for both safety and efficacy. Our strategy is to develop product candidates both for our in-house therapeutics pipeline and for partnering. For more information, please visit www.medigene.com. About Medigene’s TCR-T cells T cells are at the center of Medigene’s therapeutic approaches. Medigene’s immunotherapies help activate the patient’s own defense mechanisms, and harness T cells in the battle against cancer. Medigene’s therapies arm the patient’s own T cells with tumor-specific T cell receptors (TCRs) creating TCR-modified T cells with enhanced potential to detect and efficiently kill cancer cells. Medigene’s approach to immunotherapy is designed to overcome the patient’s tolerance of cancer cells and tumor-induced immunosuppression. By activating the patient’s T cells outside the body, genetically modifying them with tumor-specific TCRs and expanding the resultant activated TCR-T cells, patients can rapidly be given large numbers of tumor-specific T cells to fight their cancer. This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene® is a registered trademark of Medigene AG. This trademark may be owned or licensed in select locations only. Medigene Phone: +49 89 2000 3333 01E-mail: investor@medigene.com LifeSci Advisors Sandya von der WeidPhone: +41 78 680 05 38E-mail: svonderweid@lifesciadvisors.com In case you no longer wish to receive any information about Medigene, please inform us by e-mail (investor@medigene.com). 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PD-1 and PD-L1 inhibitors clinical trial pipeline constitutes 180+ key companies continuously working towards developing 200+ PD-1 and PD-L1 inhibitors drugs, analyzes DelveInsight LAS VEGAS, Nov. 14, 2022 /PRNewswire/ -- DelveInsight's ' PD-1 and PD-L1 Inhibitors Competitive Landscape – 2022 ' report provides comprehensive global coverage of available, marketed, and pipeline PD-1 and PD-L1 inhibitors drugs in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the PD-1 and PD-L1 inhibitors competitive domain. Key Takeaways from the PD-1 and PD-L1 Inhibitors Pipeline Report Over 180+ PD-1 and PD-L1 inhibitors companies are evaluating 200+ PD-1 and PD-L1 inhibitors pipeline therapies in various stages of development, and their anticipated acceptance in the PD-1 and PD-L1 inhibitors market would significantly increase market revenue. Leading PD-1 and PD-L1 inhibitors companies such as Merck, Laekna Therapeutics, Genentech, Tracon Pharmaceuticals Inc., Celgene, MedImmune, Hangzhou Sumgen Biotech, Lepu Biopharma, Harbour BioMed, Curis, BeiGene, Apollomics, Agenus, Boehringer Ingelheim, Jounce Therapeutics, Seagen Inc., Ascletis Pharma Inc., Secarna Pharmaceuticals GmbH & Co. KG, Arbutus Biopharma, ABL bio, Macrogenics, AnaptysBio, Avacta, Regeneron Pharmaceuticals, Genor Biopharma Co. Ltd, Genmab, RemeGen, Alphamab, OxSonics therapeutics, Light Chain Bioscience, ImmuneOnco Biopharma, Alpine Immune Sciences, Shanghai Henlius Biotech, Inc., Ocean Biomedical, Akeso Biopharma, Lyvgen Biopharma, Prestige Biopharma, ONO PHARMACEUTICAL CO., LTD., Innovent Biologics, QLSF Biotherapeutics Inc., Servier, Zai Lab, EQRx, Bright Peak Therapeutics, Compass Therapeutics, Inc., Y-Biologics, Shattuck Labs, Beijing Biocytogen, Transcenta Holding, KLUS Pharma Inc., Synermore Biologics, F-Star Therapeutics Inc., Alphamab Oncology, Betta Pharmaceuticals Co., Ltd., Bolt Biotherapeutics, Medicenna Therapeutics, Celldex Therapeutics Inc., TCR² Therapeutics, Transcenta Holding, Merus, SystImmune Inc., TG Therapeutics, Elpiscience, Numab, Janux Therapeutics, Adagene, Molecular Templates, Inc., ImmuneOncia, and others are evaluating novel PD-1 and PD-L1 inhibitors drug candidates to improve the treatment landscape. Key PD-1 and PD-L1 inhibitors pipeline therapies in various stages of development include Envafolimab, Keytruda, FAZ053, TECENTRIQ, Durvalumab, SG 12473, LP 002, HBM 9027, CA 170, Tislelizumab, Geptanolimab, and others. In October 2022, ChemoCentryx, Inc. announced two upcoming poster presentations for CCX559, the Company's investigational, highly potent, orally administered PD-L1 checkpoint inhibitor, at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting, which will be held November 8-12, 2022, in Boston, MA. In October 2022, Compugen Ltd., a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, announced that it will present new clinical data from its COM701/nivolumab with or without BMS-986207 combination studies in patients with platinum-resistant ovarian cancer, as well as data from the COM701 with or without nivolumab study in patients with metastatic NSCLC, as poster presentations at the European Society of Medical Oncology Immuno-Oncology (ESMO-IO) congress taking place between December 7-9, 2022, in Geneva, Switzerland. In October 2022, Imjudo (tremelimumab) from AstraZeneca was approved in the United States in combination with Imfinzi (durvalumab) for the treatment of adult patients with unresectable hepatocellular carcinoma (HCC), the most common type of liver cancer. In October 2022, GSK announced positive top-line results from the PERLA phase II trial, which met its primary endpoint of objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) criteria as determined by blinded independent central review. In September 2022, Merck announced that KEYTRUDA, Merck's anti-PD-1 therapy, received four new approvals from Japan's Ministry of Health, Labor, and Welfare (MHLW). In July 2022, TRACON Pharmaceuticals, Inc. announced the enrollment of the 36^th patient in the ENVASARC pivotal trial at the 600 mg dose of envafolimab, which enables the initial independent data monitoring committee (IDMC) interim efficacy analysis to proceed. The interim analysis is expected to occur in the fourth quarter of this year. In January 2022, Merck announced that the European Commission had approved KEYTRUDA as monotherapy for the adjuvant treatment of adults with renal cell carcinoma (RCC) at increased risk of recurrence following nephrectomy or following nephrectomy and resection of metastatic lesions. Request a sample and discover the recent advances in the PD-1 and PD-L1 inhibitors market @ PD-1 and PD-L1 Inhibitors Competitive Landscape Report PD-1 and PD-L1 Inhibitors Overview Cancer cells have programmed cell death protein 1 (PD-1) on their surfaces. Tumors use it to evade the immune system, so blocking it allows the body to attack and kill cancer. T cells constantly scan our bodies for abnormal cells and eliminate them before they can become cancerous. Finding ways to avoid or shut down the immune system is a critical step in tumor development. PD-1 proteins interact with two ligands, Programmed death-ligand 1 (PD-L1) and Programmed death-ligand 2 (PD-L2). The CD274 gene in humans encodes PD-L1. Some of the FDA-approved PD-1 inhibitor drugs include pembrolizumab (Keytruda), nivolumab (Opdivo), and cemiplimab (Libtayo). These drugs effectively treat various cancers, and new cancer types are added as more research demonstrates their efficacy. PD-L1 inhibitor drugs include atezolizumab (Tecentriq), avelumab (Bavencio), and durvalumab (Imfinzi). Find out more about PD-1 and PD-L1 inhibitors drugs @ FDA-approved PD-1 Inhibitor Drugs PD-1 and PD-L1 Inhibitors Pipeline Analysis: Drug Profile Keytruda: Merck Merck's Keytruda is a humanized monoclonal antibody that binds to the programmed cell death - 1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including anti-tumor immune response. Keytruda has been approved for advanced melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell cancer, classical Hodgkin lymphoma, microsatellite-instability-high cancer, Gastric Cancer, Esophageal Cancer, Cervical Cancer, Hepatocellular Carcinoma, Merkel Cell Carcinoma, Renal Cell Carcinoma, Endometrial Carcinoma, and advanced urothelial bladder cancer. FAZ053: Laekna Therapeutics Laekna Therapeutics is developing FAZ053 (anti-PD-L1), an investigational immuno-oncology treatment for patients with advanced cancers. It is a monoclonal antibody that targets the protein programmed cell death-1 ligand 1. (PD-L1). FAZ053, an anti-PD-L1 monoclonal antibody, binds to PD-L1, preventing it from binding to and activating its receptor programmed death 1 (PD-1), potentially enhancing the T-cell-mediated anti-tumor immune response and reversing T-cell inactivation. Laekna intends to begin trials on combination therapies as soon as possible to address unmet cancer needs and bring innovative, effective treatments to more cancer patients in China. A snapshot of the PD-1 and PD-L1 Inhibitors Pipeline Drugs mentioned in the report: Learn more about the emerging PD-1 and PD-L1 inhibitors pipeline therapies @ PD-1 and PD-L1 Inhibitors Clinical Trials Scope of the PD-1 and PD-L1 Inhibitors Competitive Landscape Report Coverage: Global Key PD-1 and PD-L1 Inhibitors Companies: Merck, Laekna Therapeutics, Genentech, Tracon Pharmaceuticals Inc., Celgene, MedImmune, Hangzhou Sumgen Biotech, Lepu Biopharma, Harbour BioMed, Curis, BeiGene, Apollomics, Agenus, Boehringer Ingelheim, Jounce Therapeutics, Seagen Inc., Ascletis Pharma Inc., Secarna Pharmaceuticals GmbH & Co. KG, Arbutus Biopharma, ABL bio, Macrogenics, AnaptysBio, Avacta, Regeneron Pharmaceuticals, Genor Biopharma Co. Ltd, Genmab, RemeGen, Alphamab, OxSonics therapeutics, Light Chain Bioscience, ImmuneOnco Biopharma, Alpine Immune Sciences, Shanghai Henlius Biotech, Inc., Ocean Biomedical, Akeso Biopharma, Lyvgen Biopharma, Prestige Biopharma, ONO PHARMACEUTICAL CO., LTD., Innovent Biologics, QLSF Biotherapeutics Inc., Servier, Zai Lab, EQRx, Bright Peak Therapeutics, Compass Therapeutics, Inc., Y-Biologics, Shattuck Labs, Beijing Biocytogen, Transcenta Holding, KLUS Pharma Inc., Synermore Biologics, F-Star Therapeutics Inc., Alphamab Oncology, Betta Pharmaceuticals Co., Ltd., Bolt Biotherapeutics, Medicenna Therapeutics, Celldex Therapeutics Inc., TCR² Therapeutics, Transcenta Holding, Merus, SystImmune Inc., TG Therapeutics, Elpiscience, Numab, Janux Therapeutics, Adagene, Molecular Templates, Inc., ImmuneOncia, and others Key PD-1 and PD-L1 Inhibitors Pipeline Therapies: Envafolimab, Keytruda, FAZ053, TECENTRIQ, Durvalumab, SG 12473, LP 002, HBM 9027, CA 170, Tislelizumab, Geptanolimab, and others. Dive deep for rich insights into PD-1 inhibitors in development; visit @ PD-L1 Inhibitor Drugs Table of Contents For further information on the PD-1 and PD-L1 inhibitors pipeline therapeutics, reach out @ PD-1 and PD-L1 Inhibitors Market Related Reports PD-1 Resistant Head and Neck Cancer Market PD-1 Resistant Head and Neck Cancer Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key PD-1 resistant head and neck cancer companies, including AstraZeneca, Innate Pharma, Rakuten Medical, Boehringer Ingelheim, Alkermes, among others. 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