Hunan Huize Biomedical Technology Co., Ltd.

Primary Objective: This study is an exploratory bioequivalence preliminary trial. Its purpose is to investigate the pharmacokinetic characteristics of a single oral dose of citrus flavonoid tablets (test formulation T, strength: 500 mg (total flavonoids)) provided by Hunan Huize Biomedical Technology Co., Ltd., and a single oral dose of citrus flavonoid tablets (reference formulation R, trade name: Aimailang®, strength: 500 mg (total flavonoids)) certified by Les Laboratoires Servier under the same fasting and postprandial conditions. The study also aims to explore analytical methods for the proposed analyte and investigate the bioequivalence of the proposed analyte's Cmax and AUC, providing a basis for the design of future formal bioequivalence clinical trial protocols and the analytical methods for analytes. Secondary Objective: To observe the safety of a single oral dose of either the test formulation or the reference formulation in healthy participants.

The study investigated the pharmacokinetic characteristics of a single oral dose of methotrexate tablets (test formulation, strength: 2.5 mg) provided by Hunan Huize Biomedical Technology Co., Ltd., and a single oral dose of methotrexate tablets (reference formulation, trade name: METHOTREXATE®, strength: 2.5 mg) certified by Pfizer Japan Inc. under the same conditions, under fasting and postprandial conditions. The aim was to evaluate the bioequivalence between the two formulations and provide a basis for the registration application of the test formulation.

Primary objective: This study investigated the pharmacokinetic characteristics of the test and control formulations under fasting conditions using HXHTT024 (10mg and 20mg) provided by Guangxi Shanhe Baisheng Technology Co., Ltd., and progesterone soft capsules (trade name: Anqitan®, 0.1g) certified by Besins Healthcare Benelux. Secondary objective: To observe the safety of a single dose of the test formulation HXHTT024 (10mg and 20mg) or the control formulation progesterone soft capsules (trade name: Anqitan®, 0.1g) in healthy participants.