Delving into the Latest Updates on Hangzhou MSD Pharmaceutical Co. Ltd. with Synapse

Overview

Tags

Nervous System Diseases

Congenital Disorders

Endocrinology and Metabolic Disease

Multivalent vaccine

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Infectious Diseases	1
Nervous System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Multivalent vaccine	1
Diagnostic radiopharmaceuticals	1
Conjugated vaccine	1
Prophylactic vaccine	1
Chemical drugs	1

Top 5 Target	Count

PDE10A(Phosphodiesterase 10A)	1
HMG-CoA reductase	1
ELA2(Leukocyte elastase)	1

A new method for synthesis of 4, 5-dihydro-1, 4-oxazepines is reported.Using readily available 1-sulfonyl-1, 2, 3-triazoles and α, β-unsaturated aldehydes as starting materials, 1, 4-oxazepines were synthesized conveniently in moderate yields in the presence of Rh2(Oct)4.Moreover, this transformation manifests the potential utility of 1-sulfonyl-1, 2, 3-triazole as precursor of aza-1, 3-dipole in formal 4+3 cyclization.

Advanced Materials Research

Finite Element Analyses and Model of Squeeze Casting Process for Producing Magnesium Wheels

Author: Jin, Yin ; Lin, Chang Jiang ; Tang, Hong Qing

A finite element equation has been developed to simulate the squeeze casting process of a magnesium alloy wheel, a parametric model has been established to confirm the temperature field during filling and solidification process. The model can be used to investigate the effects of die design and process parameters (die temperature, pressure etc.) on the quality of castings.

Advanced Materials Research

The Numerical Simulation and Optimization of Squeeze Casting Process for Producing Magnesium Wheels

Author: Tang, Hong Qiang ; Yao, Rong Qing

The simulation of squeeze casting process of a magnesium alloy wheel was practice. Using professional casting software, the temperature field during filling and solidification process, and then the potential defects were forecasted and previewed. It was found that there would be shrinkage defects at the center and the junctions between the rim and the spokes of the wheel. It is better to choose a mould temperature for a better cast property at meet of full-filling. Number of programs are analyzed and compared through orthogonal experiment. And the best parameter team is educed through analysis. It is confirmed that the potential micro-shrinkage is reduced by simulated again using the best parameter team. And the cast property is enhanced.

100 Deals associated with Hangzhou MSD Pharmaceutical Co. Ltd.

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100 Translational Medicine associated with Hangzhou MSD Pharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 25 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

1

Approved

Other

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Simvastatin ( HMG-CoA reductase )	Hyperlipoproteinemia Type V More	Approved
24 valent pneumococcal polysaccharide conjugate vaccine(MSD)	Streptococcal Infections More	Preclinical
MK-0339 ( ELA2 )	Neutropenia More	Preclinical
[11C]MK-8193 ( PDE10A )	Neoplasms More	Preclinical
PFE-360 ( LRRK2 )	Parkinson Disease More	Pending