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Nervous System Diseases

Congenital Disorders

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Disease Domain	Count

Immune System Diseases	1
Nervous System Diseases	1

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HMGB1(High Mobility Group Protein B1)	1

Modification and control of surface properties, such as surface tension γ at air-liquid (AL) interfaces and surface energy at solid-liquid (SL) surfaces, are at the heart of colloid and interface science. Certain applications require low or very low surface tensions γ_AL and surface energies γ_SL, for example and not limited to: microemulsification, aqueous foams for fire-fighting, hydrophobic, superhydrophobic and oleophobic surfaces to control spreading and wetting of aqueous and oily liquids on solids. In many cases low surface tensions/energies can only be obtained by employing perfluoroalkyl substances (PFAS) as surfactant or polymer additives or surface treatments. Although fluorocarbons and polymers have been employed for over 80 years, with many industrial and commercial benefits, it is now recognized that PFAS are very hazardous to the environment and health. Hence, in the coming years it will be necessary to phase out PFAS entirely, however, at present, there are very few viable alternatives available. This article outlines the chemical principles for designing F-free low surface energy (LSE) additives, and also covers the most recent advances in the quest for non-fluorinated surfactants and polymeric surface coatings.

01 Jul 2025·Archives of Gerontology and Geriatrics

Understanding physical aging in relation to biological aging, telomere length: A systematic review

Review

Author: Paing, Arkar Min ; Wai, Kyi Mar ; Swe, Thinzar

BACKGROUNDTelomere length (TL) serves as a marker for biological aging, influenced by chronological aging but distinct from it. This systematic review aims to synthesize the evidence on the associations between components of physical aging and TL in the elderly population.METHODSA comprehensive search was conducted in online databases of PubMed, Web of Science, ProQuest, and ScienceDirect to identify the eligible papers published until 1st August 2024. The authors independently extracted data using the standardized form. The quality of the included studies was evaluated for the risks of biases.RESULTSA total of 1080 records were initially identified using the predefined search strategy. A total of 40 eligible records were included in this review. When assessing physical aging, the nature and type of measurements across studies vary, including subjective, objective, and a combination of both approaches. Subjective assessments of general health or physical limitations may be linked with TL, while frailty, whether measured subjectively or objectively, shows associations with TL in less than 35 percent of total studies. In contrast, composite measures of physical performance/ability are consistently associated with TL in the elderly population.CONCLUSIONSIn conclusion, we demonstrated that the associations between physical aging and TL varies depending on the type and nature of physical aging assessments. Composite measures of physical performance/ability demonstrate a strong and consistent parameter of physical aging to link with TL. Future research should prioritize standardized, multidimensional approaches to measure physical aging to understand better its association with TL to support healthy aging strategies.

01 Jul 2025·Journal of Materials Science & Technology

Highly effective CO2 electroreduction to formate boosted by Ce-doping on Indium oxide electrocatalysts

Author: Zhang, Juan ; Jin, Yuxia ; Ramli, Yusrin ; An, Xiaowei ; Feng, Zhongbao ; Li, Shasha ; Yang, Ziyuan ; Hao, Xiaogang ; Zhou, Yifan ; Guan, Guoqing ; Abudula, Abuliti ; Feng, Changrui ; Luo, Peng ; Du, Xiao ; Wang, Peifen

Electrocatalytic reduction of carbon dioxide (CO₂) with high selectivity to generate value-added chem. products and fuels, utilizing renewable electricity sources, offers an effective approach to address the continued increase in atm. CO₂.Here, we report cerium (Ce)-doped indium oxide (In₂ O₃) electro-catalyst generated in situ on carbon paper (Ce-In₂ O₃ /CP), and its application in the electrochem. reduction of CO₂ (CO₂ RR) to formate formation with high Faradaic efficiency (FE) (reaching 97.6% at -1.7 V vs.Ag/AgCl) and excellent stability.Exptl. anal. and d. functional theory (DFT) calculations indicate that doping Ce onto the (222) plane of In₂ O₃ induces lattice distortion, which promotes electron transfer from Ce to In while adjusting the local electronic structure of the In atoms around Ce, making them more favorable for the adsorption of *OOCH intermediates and effectively lowering the energy bar-rier of the rate-determining step.Furthermore, Ce doping lowers the overpotential required for formate production and suppresses the hydrogen evolution reaction (HER), effectively enhancing the selectivity of formate.

100 Deals associated with Hirosaki University

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Pipeline

Pipeline Snapshot as of 09 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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