Dandong Yichang Pharmaceutical Co., Ltd.

Primary objective: To compare the in vivo blood concentrations and main pharmacokinetic parameters of the test preparation of promethazine hydrochloride tablets (specification: 25 mg, Dandong Yichuang Pharmaceutical Co., Ltd.) and the reference preparation (specification: 25 mg, Phenergan®, licensed by Sanofi) after a single oral administration in the fasting state and the fed state in healthy subjects, and to evaluate the bioequivalence of the two preparations. Secondary objective: To evaluate the safety of the two preparations in the fasting state and the fed state in healthy subjects.

The main purpose of the study is to use the metformin hydrochloride tablets (trade name: Glycoran) certified by NIPPON SHINYAKU CO., LTD. as the reference preparation and the metformin hydrochloride tablets produced by Dandong Yichuang Pharmaceutical Co., Ltd. as the test preparation to evaluate the bioequivalence of the two preparations in humans through a single-center, randomized, open, single-dose, two-cycle, double-crossover clinical study. Secondary purpose of the study: To observe the safety of the test preparation and the reference preparation in healthy Chinese subjects.