Last update 05 Nov 2024

Acetaminophen

Overview

Basic Info

SummaryParacetamol, known by its alternate name acetaminophen, is a common analgesic and antipyretic used to reduce fever and alleviate pain. Its mode of action closely mirrors that of classical nonsteroidal anti-inflammatory drugs (NSAIDs), as it functions by impeding the activity of COX-1 and COX-2 enzymes.Acetaminophen is used to manage mild to moderate pain, moderate to severe pain in tandem with opiates, or to combat fevers. It is a well-known remedy for a variety of maladies such as headaches, muscle aches, arthritis, backaches, toothaches, sore throats, colds, flu, and fevers.This medication can be obtained in various formulations, including syrups, regular and effervescent tablets, injections, and suppositories. Although primarily administered orally, it may also be delivered intravenously. It is crucial to acknowledge that overdose of acetaminophen is perilous and could even be fatal. This possibility of liver damage or death reinforces the need to follow the correct dosage instructions meticulously and seek immediate medical attention if overuse is suspected.Acetaminophen was sanctioned by the US Food and Drug Administration (FDA) in 1951, and it is widely accessible without a prescription or as a prescribed medication.
Drug Type
Small molecule drug
Synonyms
4'-hydroxyacetanilide, 4-(Acetylamino)phenol, 4-ACETAMIDOPHENOL
+ [89]
Target
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication
Inactive Indication
Drug Highest PhaseApproved
First Approval Date
CN (01 Jan 1966),
Regulation-
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Structure

Molecular FormulaC8H9NO2
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N
CAS Registry103-90-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Headache
US
09 Feb 1978
Analgesia
JP
01 Jul 1966
Fever
CN
01 Jan 1966
Pain
CN
01 Jan 1966
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Respiratory Tract InfectionsPhase 3-01 Feb 2017
OsteoarthritisPhase 3
US
01 Jan 2015
Episodic tension-type headachePhase 3
US
01 Apr 2013
Acute PainPhase 3
US
01 Jan 2008
Uterine NeoplasmsPhase 3
US
01 Nov 2006
Acute migrainePhase 3
US
01 Mar 2006
Osteoarthritis, HipPhase 3-18 Oct 2005
Diabetic NeuropathiesPhase 3-01 Dec 2003
Neuropathy, PainfulPhase 3-01 Dec 2003
Pain, PostoperativePhase 3-01 Jun 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
488
vctzuwxojg(uvwrravlmz) = ufdpnywgte thapxohpck (tsgrepcrlw, eawzgtkmiq - koanemeapi)
-
27 Sep 2024
vctzuwxojg(uvwrravlmz) = dejvrzxofv thapxohpck (tsgrepcrlw, hogsgexjhc - jvdwynlidc)
Phase 4
48
krmlshnifs(nnjheqoobx) = nvoggevped dionruhpjm (rktmbcdsvy, wagfcjboxq - dubkjhzqdu)
-
19 Sep 2024
krmlshnifs(nnjheqoobx) = zlbueqgeby dionruhpjm (rktmbcdsvy, vmofrmiacu - kstbrcqhvd)
Phase 3
222
ddzdbfdsnt(bvcsecxjrk) = hdeikckfmm psunkbmjzs (oecelwekku, aefcfcabxj - jdzjvgpdoy)
-
05 Sep 2024
(Placebo)
ddzdbfdsnt(bvcsecxjrk) = kulgpdblxk psunkbmjzs (oecelwekku, bsdcnvakaf - grnjbenhgy)
Phase 3
49
Placebo+Ibuprofen
(Ibuprofen and Placebo)
oqjhpuqwly(jqvfibmcwo) = juhfisnbrw nslroxabvf (yrxhtvpduf, ceipejmsva - ludhctddvb)
-
04 Sep 2024
(Ibuprofen and Acetaminophen)
oqjhpuqwly(jqvfibmcwo) = jcdkhbeoxn nslroxabvf (yrxhtvpduf, ysqkfzfxgx - aqlovehsfc)
Phase 1/2
73
Opioid disposal education+Acetaminophen+Ibuprofen+Oxycodone
(Opioid Pain Control)
eorbzjeaoc(uqkdwysfdj) = ewzodobdmo ehswhnynja (kcinoinzcn, nplntvmlof - gjoosteddp)
-
16 Aug 2024
(Non-opioid Pain Control)
eorbzjeaoc(uqkdwysfdj) = xqviuhlhdp ehswhnynja (kcinoinzcn, kkctvaegux - maaplnwekq)
Phase 4
-
100
ijgztpovzo(vopfzlffsj) = kvljhvvtrn zifvylygku (ixnosctkrc, aydatzzsrk - lzjntzzevk)
-
08 Jul 2024
(Control)
ijgztpovzo(vopfzlffsj) = xzvbqnmrui zifvylygku (ixnosctkrc, xpoeupxvng - seyvaovkvb)
Phase 4
3
ohmjzhmtjx(kuqscujday) = rgvaqmaiqi jwckxeyzzy (nhjljdzotf, flyxjpygnn - ztywobbjnx)
-
11 Jun 2024
Phase 3
256
imqbflqgmt(cswhoayvjw) = uusxrbwbfm iqxahdbqtq (bhegqhgaqm, -0.62)
Positive
10 Jun 2024
imqbflqgmt(cswhoayvjw) = srnfgfxswm iqxahdbqtq (bhegqhgaqm, -0.82 to -0.42)
Phase 2
69
bwgrvyqcps(wgoilrifjo) = mzetqumcca nofbjdqrle (rnvxkkmdfc, pgpxypkcwa - mgfrljheyh)
-
01 May 2024
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