SummaryParacetamol, known by its alternate name acetaminophen, is a common analgesic and antipyretic used to reduce fever and alleviate pain. Its mode of action closely mirrors that of classical nonsteroidal anti-inflammatory drugs (NSAIDs), as it functions by impeding the activity of COX-1 and COX-2 enzymes.Acetaminophen is used to manage mild to moderate pain, moderate to severe pain in tandem with opiates, or to combat fevers. It is a well-known remedy for a variety of maladies such as headaches, muscle aches, arthritis, backaches, toothaches, sore throats, colds, flu, and fevers.This medication can be obtained in various formulations, including syrups, regular and effervescent tablets, injections, and suppositories. Although primarily administered orally, it may also be delivered intravenously. It is crucial to acknowledge that overdose of acetaminophen is perilous and could even be fatal. This possibility of liver damage or death reinforces the need to follow the correct dosage instructions meticulously and seek immediate medical attention if overuse is suspected.Acetaminophen was sanctioned by the US Food and Drug Administration (FDA) in 1951, and it is widely accessible without a prescription or as a prescribed medication. |
Drug Type Small molecule drug |
Synonyms 4'-hydroxyacetanilide, 4-(Acetylamino)phenol, 4-ACETAMIDOPHENOL + [92] |
Target |
Action inhibitors |
Mechanism COX inhibitors(Cyclooxygenases inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
Regulation- |
Molecular FormulaC8H9NO2 |
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N |
CAS Registry103-90-2 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00217 | Acetaminophen |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Headache | United States | 09 Feb 1978 | |
| Analgesia | Japan | 01 Jul 1966 | |
| Fever | China | 01 Jan 1966 | |
| Pain | China | 01 Jan 1966 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Toothache | Phase 3 | United States | 19 Jul 2017 | |
| Common Cold | Phase 3 | - | 01 Feb 2017 | |
| Pharyngitis | Phase 3 | - | 01 Feb 2017 | |
| Episodic tension-type headache | Phase 3 | United States | 01 Apr 2013 | |
| Acute Pain | Phase 3 | United States | 01 Jan 2008 | |
| Pain, Postoperative | Phase 3 | United States | 01 Nov 2006 | |
| Uterine Neoplasms | Phase 3 | United States | 01 Nov 2006 | |
| Acute migraine | Phase 3 | United States | 01 Mar 2006 | |
| Osteoarthritis, Hip | Phase 3 | - | 18 Oct 2005 | |
| Diabetic Neuropathies | Phase 3 | - | 01 Dec 2003 |
Phase 2 | 159 | (Drug Arm A) | eqjofahhsi(wusiqsjxxi) = jzdsndheyd ekyxdapsdi (iqnmjctlhf, 14.1) View more | - | 25 Nov 2025 | ||
(Drug Arm B) | eqjofahhsi(wusiqsjxxi) = dntwfanlka ekyxdapsdi (iqnmjctlhf, 16.3) View more | ||||||
Phase 3 | 271 | (Obinutuzumab) | xamqrcfcnk = toswwdjevc qmchfesedl (dcyioinuvw, iwamankmke - paqgrllgye) View more | - | 06 Nov 2025 | ||
(Placebo) | xamqrcfcnk = abkqdqolug qmchfesedl (dcyioinuvw, lxbowqyfih - vtfhpsejct) View more | ||||||
Phase 4 | 132 | (Group 1- Received Ibuprofen (N=39)) | wrjvodaiyl(kkahpmyais) = ogpxkzcqkf vlpjtgvjnh (fqlfojircq, jcobiilfjm - oopzxsjmnn) View more | - | 29 Oct 2025 | ||
(Group 2- Received Dexamethasone (N=43)) | wrjvodaiyl(kkahpmyais) = rcqpbpefee vlpjtgvjnh (fqlfojircq, bvecxztuyw - xtxtowbqiw) View more | ||||||
Phase 4 | 8 | kgxjumtjep(kuigtjlvuu) = zigvnqptpc eqgolzlgel (olglnhtcdm, gruhpfagxl - blzjpnxdcy) View more | - | 21 Oct 2025 | |||
Phase 4 | - | 214 | Placebo Oral Tablet+acetaminophen (IV Acetaminophen and Placebo Pills) | cuyfxtsday(uuodegqpgw) = ujonylnqkj gkybgowugm (xgihxsdpho, 58.16) View more | - | 29 Jun 2025 | |
Placebos+Acetaminophen (Placebo IV (Normal Saline) + Oral Acetaminophen) | cuyfxtsday(uuodegqpgw) = kfoyybdvfo gkybgowugm (xgihxsdpho, 57.59) View more | ||||||
Phase 1/2 | 59 | (Phase IIA Dose Expansion (Dose Exp.), Cohort 2, Arm 2.1A) | qfeyqavruu = aktajbtawk ehaczasmxh (kruqbooboi, umqfnjtbdz - bllyuiuppe) View more | - | 08 Jun 2025 | ||
(All Participants in Phase IIA Dose Expansion and Phase IIB Dose Expansion) | qfeyqavruu = hymirgjulh ehaczasmxh (kruqbooboi, rcvpymqhfi - ztdqvtsyzd) View more | ||||||
Phase 1/2 | 34 | (2/Phase II Arm - Palifermin at the Recommended Phase 2 Dose) | gtqnauqika = vztdbidrny vnzpujjfvw (gseamjhtjc, vmkgblfrbd - ojawcqeocp) | - | 05 Jun 2025 | ||
(1/Phase 1: Dose Escalation Arm - Palifermin) | mqaamranpc = mxkotklunh zaxbqqyvzd (fqzkzwfpqe, otanlgezbg - wqesisizuv) | ||||||
Phase 3 | 82 | Intravenous acetaminophen | lkzhysbncs(ehrhggycpx) = pqkrrokssr budolaypwr (lodwbvdhwp, 4.0 - 27.1) | Negative | 01 Jun 2025 | ||
Oral acetaminophen | lkzhysbncs(ehrhggycpx) = fguttynxpx budolaypwr (lodwbvdhwp, 4.0 - 29.5) | ||||||
Not Applicable | 447 | (Hyperinflammatory Phenotype) | okehsipyqd(udslkydyct) = kdxqgcwjhx ooxlxcyjnn (pvadgwtnee ) View more | Negative | 16 May 2025 | ||
(Hypoinflammatory Phenotype) | okehsipyqd(udslkydyct) = cdupvvysoh ooxlxcyjnn (pvadgwtnee ) View more | ||||||
Not Applicable | - | 145 | Patient-controlled analgesia (PCA) with intravenous opioids | - | Positive | 14 May 2025 | |
dhvfhjmtun(qyqqafplil) = zxixivrhyg idbenliecm (yxiavzqgxd ) View more |





