Secondary ethanol precipitation and subsequent processes of Guanxinning injections were improved.With residue mass as index, necessity of frozen and filtration steps after secondary ethanol precipitation was investigated.With the contents of sodium danshensu, protocatechuic aldehyde, rosmarinic acid, ferulic acid and salvianolic acid B as indexes, effects of the concentration of adding ethanol, pH and ethanol concentration on secondary ethanol precipitation and subsequent processes were investigated.Frozen step in original standard process could be negligible.The contents of five kinds of characteristics components in Guanxinning injections were all improved effectively when ethanol content was adjusted to 80% with 90% ethanol in secondary alc. precipitation and pH was adjusted to 8.0-8.2 after secondary alc. precipitationImprovement process of Guanxinning injections could better control liquid color and finished products quality, it could be widely applied with shortening production cycle.