Shandong Liangfu Pharmaceutical Co., Ltd

Main research purpose: According to the relevant provisions of bioequivalence test, Bisoprolol Amlodipine Tablets (trade name: Kangxinan, specification: 5mg bisoprolol fumarate and 5mg amlodipine besylate (calculated as amlodipine)) with Merck Kft as the licensee was selected as the reference preparation, and the test preparation Bisoprolol Amlodipine Tablets (specification: 5mg bisoprolol fumarate and 5mg amlodipine besylate (calculated as amlodipine)) produced by Yantai Luyin Pharmaceutical Co., Ltd. and provided by Jinan Liangfu Jinghe Pharmaceutical Technology Co., Ltd. were subjected to fasting and postprandial human bioequivalence test, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting and postprandial administration conditions. Secondary study objective: To observe the safety of oral administration of the test preparation bisoprolol amlodipine tablets (specifications: 5 mg bisoprolol fumarate and 5 mg amlodipine besylate (calculated as amlodipine)) and the reference preparation bisoprolol amlodipine tablets (trade name: Kangxinan, specifications: 5 mg bisoprolol fumarate and 5 mg amlodipine besylate (calculated as amlodipine)) to healthy subjects.

Main purpose: This study used Avatrombopag Maleate Tablets (Specification: 20 mg) certified by Shandong Liangfu Pharmaceutical Co., Ltd. as the test preparation, and Avatrombopag Maleate Tablets (Trade name: Su Kexin, Specification: 20 mg) certified by AkaRx Inc. as the reference preparation according to the relevant provisions of the bioequivalence test. The human bioequivalence test was conducted under fasting/postprandial conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.