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Last update 23 Jan 2025

BTN1A1

Last update 23 Jan 2025

Basic Info

Synonyms

BT, BTN, BTN1

+ [2]

Introduction

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).

Drugs associated with BTN1A1

Nelmastobart

Target

BTN1A1

Mechanism

BTN1A1 inhibitors

Active Org.

STCube, Inc.

Originator Org.

STCube, Inc.

Active Indication

Head and Neck Neoplasms [+3]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with BTN1A1

NCT06016270

/ RecruitingPhase 1/2

A Phase Ib/II Study of hSTC810 in Combination With Paclitaxel in Relapsed or Refractory Extensive Stage Small Cell Lung Cancer

The purpose of this clinical study is to assess the safety and efficacy of hSTC810 and paclitaxel combination therapy in patients with relapsed or refractory extensive stage small cell lung cancer.

Start Date13 Feb 2024

Sponsor / Collaborator

STCube, Inc.

NCT05231746

/ CompletedPhase 1

A Phase 1, Multicenter, Open-label Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of hSTC810 Monotherapy in Subjects With Advanced Solid Tumors

The Purpose of this study is to investigate the safety, tolerability, pharmacokinetics, and preliminary efficacy of hSTC810 monotherapy in participants with advanced solid tumors.

Start Date18 Apr 2022

Sponsor / Collaborator

STCube, Inc.

100 Clinical Results associated with BTN1A1

100 Translational Medicine associated with BTN1A1

0 Patents (Medical) associated with BTN1A1

133

Literatures (Medical) associated with BTN1A1

01 Feb 2025·Food Chemistry

Size-dependent composition and in-situ structure analysis of the milk fat globule membrane in buffalo milk

Article

Author: Zhang, Weibo ; Yu, Jinghua ; Ren, Fazheng ; Wu, Shouyun ; Wu, Peipei ; Wang, Yi ; Wei, Jianhuan ; Wang, Pengjie ; Luo, Jie ; Chen, Chong ; Guo, Mengyuan

This study provides insights into the composition and in-situ structures of the milk fat globule membrane (MFGM) in buffalo milk with different fat globule sizes (0.55 μm and 8.04 μm). Small fat globules contained a higher amount of MFGM proteins and polar lipids, while the content of MFGM components (except for ADPH) was greater per unit membrane area in large fat globules. A total of 386 differentially expressed proteins were identified, with many of the most differentially expressed proteins being associated with human diseases, such as cancer and elderly diseases. The coverage of sphingomyelin and certain MFGM proteins (BTN and PAS 6/7) on large fat globules was higher, potentially linked to the presence of larger, irregular lipid rafts and patch-shaped glycocalyxes, respectively. These findings suggest that small fat globules are suitable for nutritional fortification of buffalo milk, while large fat globules are appropriate for the preparation of functional dairy-based ingredients.

01 Dec 2024·Journal of Dairy Science

Proteomics and surface free fatty acid analysis of milk fat globule in the spray- and freeze-dried bovine, goat and horse milk powders

Article

Author: Fan, Rongbo ; Zhou, Shichu ; Wang, Jun ; Bu, Dengpan ; Yang, Yongxin ; Zhang, Xin ; Han, Rongwei

Changes in the structure and composition of milk fat globules in spray- and freeze-dried milk powders have recently garnered significant attention. This study investigated changes in milk fat globular membrane (MFGM) proteins from bovine, goat, and horse milk powders, both spray- and freeze-dried, using a label-free proteomics approach, and quantified surface free fatty acids and their composition using gas chromatography. The results showed that several proteins of α_S2-casein and β-lactoglobulin increased, while fibrinogen α, β chain, and mucin-1 decreased in the MFGM fractions of the studied spray-dried milk powders. Additionally, lactoperoxidase and polymeric immunoglobulin receptor levels were elevated in the studied freeze-dried milk powders. Several proteins exhibited variations in both dried milk powders depending on the species, of these, nucleobindin-1, complement C3, and sulfhydryl oxidase were increased in spray-dried bovine and goat milk powders, and lactoferrin was increased in freeze-dried horse milk powder, compared with their raw milk counterparts. Conversely, butyrophilin subfamily 1 member A1 and xanthine dehydrogenase/oxidase were decreased in spray-dried bovine and goat milk powders, S100 calcium-binding protein and aldehyde dehydrogenase were decreased in freeze-dried bovine and goat milk powders, and mucin-4 and paraoxonase were decreased in horse milk powder. Additionally, spray-dried milk powders had lower surface free fatty acid content compared with freeze-dried milk powders. The findings underscore that dried methods exert varied impacts on MFGM components of the studied milk sources, thereby providing a valuable reference for improving the nutritional quality of dried dairy products.

01 Oct 2024·European Journal of Medicinal Chemistry

Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1

Article

Author: Wiemer, Andrew J ; Hsiao, Chia-Hung Christine ; Jin, Yiming ; Rani, Sarita ; Singh, Rohit

Phosphoantigens (pAgs) induce conformational changes after binding to the intracellular region of BTN3A1 which result in its clustering with BTN2A1, forming an activating ligand for the Vγ9Vδ2 T cell receptor. Here, we designed a small panel of bulky analogs of the prototypical pAg (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) that contain an aromatic ring attached to the C-3 position in place of methyl group. These compounds bind with high affinity to BTN3A1 but fail to fully support its interaction with BTN2A1 and only partially trigger T cell activation relative to HMBPP. Furthermore, they can compete with HMBPP for cellular binding to BTN3A1 and reduce the cellular response to HMBPP, a classic partial agonist phenotype. Trifluoromethyl analog 6e was the weakest agonist but the strongest inhibitor of HMBPP ELISA response. Our study provides a rationale for the mode of action of pAg-induced γδ T cell activation and provides insights into other naturally occurring BTN proteins and their respective ligands.

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BTN1A1

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