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The demand for heparin is mainly increasing due to the growing incidence of cardiovascular diseases, the expanding range of cancer risk factors such as smoking, radiation exposure, unhealthy lifestyles, and other factors, as well as the rising research and development activities by global market players throughout the forecast period from 2024 to 2030. LAS VEGAS, Sept. 4, 2024 /PRNewswire/ -- DelveInsight's Heparin Market Insights report provides the current and forecast market analysis, individual leading heparin companies' market shares, challenges, heparin market drivers, barriers, trends, and key market heparin companies in the market. Key Takeaways from the Heparin Market Report As per DelveInsight estimates, North America is anticipated to dominate the global heparin market during the forecast period. In the application segment of the heparin market, the coronary artery disease category had a significant revenue share in the Heparin market in 2023. Notable heparin companies such as Pfizer Inc., Leo Pharma A/S, Dr. Reddy's Laboratories Ltd., GSK plc., Sanofi, B. Braun Melsungen AG, Aspen Holdings, Fresenius SE & Co. KGaA, Novartis AG, Baxter, and several others, are currently operating in the heparin market. In November 2023, the FDA approved a taurolidine plus heparin (DefenCath®) catheter lock solution to reduce catheter-related bloodstream infections in patients receiving maintenance hemodialysis via a central venous catheter (CVC). In February 2022, Techdow USA Inc. announced the launch of its Heparin Sodium Injection, USP in the US market. In January 2022, the Ohio biotechnology firm Optimvia Pharmaceuticals developed a cost-effective synthetic method to produce large quantities of heparin, used to make common blood thinner, also striking a deal with the synthetic biology firm Ginkgo Bioworks to scale the process up. To read more about the latest highlights related to the heparin market, get a snapshot of the key highlights entailed in the Global Heparin Market Report Heparin Overview Heparin is a widely used anticoagulant medication that helps prevent and treat blood clots. It works by enhancing the activity of antithrombin III, a protein in the blood that inhibits blood clotting factors such as thrombin and factor Xa. Heparin is administered either intravenously or subcutaneously and is commonly used in medical settings such as during surgeries, dialysis, and for patients with certain types of heart disease. Its rapid onset and short duration of action make it particularly useful in acute settings where quick and reversible anticoagulation is needed. Despite its effectiveness, heparin therapy requires careful monitoring due to the risk of bleeding complications. One of the most significant side effects is heparin-induced thrombocytopenia (HIT), a condition where the patient's platelet count drops dramatically, which paradoxically increases the risk of thrombosis. To manage these risks, healthcare providers regularly monitor blood clotting parameters, such as activated partial thromboplastin time (aPTT), to ensure that the patient remains within a therapeutic range. In cases where heparin use is contraindicated or needs to be discontinued, alternative anticoagulants, such as low molecular weight heparins or direct oral anticoagulants, may be considered. Heparin Market Insights In 2023, North America held the largest share of the heparin market compared to other regions. This is attributed to the rising incidence of cardiovascular disorders in the area. Contributing factors include the increasing risk factors related to cardiovascular issues, strong research and development efforts, and a highly promising market for product development and launches, all of which are driving the growth of the heparin market in North America. Additionally, the growing number of heparin product launches is anticipated to drive the heparin market in North America. For instance, in February 2024, B. Braun Medical Inc. introduced its new Heparin Sodium 2,000 units in 0.9% Sodium Chloride Injection, 1,000 mL (2 units/mL), marking the fifth addition to its range of Heparin premixed bags. This launch underscores B. Braun's dedication to enhancing supply security by producing pharmaceuticals in the U.S. at its Irvine, CA facility. Given the substantial patient population in North America, the use of heparin for treatment is expected to boost market demand in the coming years. Consequently, these factors combined are projected to contribute to the growth of the heparin market in North America during the forecast period from 2024 to 2030. To know more about why North America is leading the market growth in the heparin market, get a snapshot of the Heparin Market Outlook Heparin Market Dynamics The heparin market is a critical segment within the global pharmaceutical industry, primarily driven by its essential role in anticoagulant therapy. The market dynamics are influenced by a variety of factors including technological advancements, regulatory changes, and shifts in healthcare practices. One significant driver in the heparin market is the ongoing innovation in drug delivery systems and formulations. Advances such as low molecular weight heparins (LMWHs) have improved the efficacy and safety profiles of heparin therapy, leading to increased adoption. Additionally, the development of more efficient manufacturing processes, such as recombinant heparins, has helped meet the growing demand and reduce dependency on animal sources, which can be susceptible to supply chain disruptions. Regulatory factors also play a crucial role in shaping the heparin market. Regulatory agencies, such as the FDA and the EMA, impose stringent standards on the production and quality of heparin products. These regulations are designed to ensure the safety and efficacy of heparin, which can impact market dynamics through compliance costs and potential market entry barriers for new players. Moreover, market dynamics are influenced by global healthcare trends and economic factors. Rising incidences of cardiovascular diseases and an aging population contribute to the increased demand for heparin. However, economic pressures and healthcare cost containment strategies may impact market growth. Furthermore, competition from alternative anticoagulants and biosimilars can also affect the heparin market by offering patients and healthcare providers additional options. Get a sneak peek at the heparin market dynamics @ Heparin Market Dynamics Analysis Heparin Market Assessment Heparin Market Segmentation Heparin Market Segmentation By Source: Bovine, Porcine, and Others Heparin Market Segmentation By Route of Administration: Subcutaneous and Intravenous Heparin Market Segmentation By Application: Coronary Artery Disease, Atrial Fibrillation, Venous Thromboembolism, Renal Impairment, and Others Heparin Market Segmentation By Geography: North America, Europe, Asia-Pacific, and Rest of World Porter's Five Forces Analysis, Product Profiles, Case Studies, KOL's Views, Analyst's View Which MedTech key players in the heparin market are set to emerge as the trendsetter explore @ Heparin Companies Table of Contents Interested in knowing the heparin market by 2030? Click to get a snapshot of the Heparin Market Trends Related Reports Heparin-induced Thrombocytopenia Market Heparin-induced Thrombocytopenia Market Insight, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of market trends, market drivers, market barriers, and key heparin-induced thrombocytopenia companies, including Sandoz, Fresenius Kabi, Hikma Pharm, Veralox Therapeutics, among others. Thrombocytopenia Market Thrombocytopenia Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key thrombocytopenia companies, including Sanofi, Principia Biopharma, Baxalta, Takeda, Argenx, Millennium Pharmaceuticals, Biotest, GC Pharma, Genosco (Subsidiary of Oscotec), Rigel Pharmaceuticals, Kissei Pharmaceutical, Shionogi & Co., Ltd, Amgen, Novartis, Zenyaku Kogyo, among others. Thrombocytopenia Pipeline Thrombocytopenia Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key thrombocytopenia companies, including Takeda, Argenx, Keros Therapeutics, Principia Biopharma, Momenta Pharmaceuticals, Veralox Therapeutics, Novartis Pharmaceuticals, Pfizer, HUTCHMED, Principia Biopharma, Genosco, UCB, among others. Immune Thrombocytopenia Immune Thrombocytopenia Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key immune thrombocytopenia companies, including UCB Biopharma, Sanofi, Principia Biopharma, Argenx, Millennium Pharmaceuticals, Takeda, Biotest, GC Pharma, UCB, HanAll Biopharma, Immunovant, Momenta Pharmaceuticals, Hutchison MediPharma, Cour Pharmaceutical Development, among others. About DelveInsight DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Contact Us Shruti Thakur [email protected] +14699457679 Logo: SOURCE DelveInsight Business Research, LLP

CAIRO and PARIS, Dec. 10, 2023 /PRNewswire/ -- Sanofi and Minapharm announce the signing of an exclusive Manufacturing and Supply Agreement for the localization of the full range of its flagship market leader product, Clexane®. Continue Reading Sanofi and Minapharm Sign an Exclusive Agreement for Localizing the manufacture of Clexane® (PRNewsfoto/Minapharm Pharmaceuticals) The agreement between Sanofi, a global pharmaceutical company and Egypt's Minapharm, a regional Biotech company with wholly owned subsidiaries in Cairo and Berlin, boosts Egypt's national localization strategy of biopharmaceutical manufacturing. This move towards localizing the manufacturing of Sanofi's Clexane® adapts to changing market dynamics and enhancement of industrial innovative technologies. The manufacturing of Clexane® will take place in Minapharm's second new state-of-the-art biopharmaceutical facility in Egypt dedicated to research, development and manufacture of complex bioengineered proteins. In the presence of Sanofi Senior Management, Christelle Saghbini, Head of Innovate to Grow Markets, Jeremy Goldnadel, Cluster Head International General Medicine and Ahmed Youssef, Head of Manufacturing site, the agreement between the 2 companies has been signed by Dr. Ahmed Raouf, Managing director & Chairperson on behalf of Sanofi Egypt, and by Dr. Wafik Bardissi, Chairman and CEO of Minapharm on behalf of Minapharm. Dr. Ahmed Raouf, Managing Director and Chairperson of Sanofi Egypt said:" This agreement affirms Sanofi Egypt's pledge to support the localization plan of pharmaceutical and biological industries in Egypt by transfer of advanced manufacturing technology in cooperation with distinctive industry partners. This event comes as a continuation of efforts to provide essential and modern treatments to the Egyptian patient." Dr. Wafik Bardissi, Chairman and CEO of Minapharm said: "This partnership with Sanofi corroborates the common national health policy directives with the commitment of both parties to ensure elevated patient access to essential complex biologics. It further complements the local, regional and global technology contribution of Minapharm and its European subsidiaries to the world's bio-industry." About Sanofi SANOFI Egypt is an affiliate of SANOFI, a global healthcare leader with more than 100,000 employees in 100 countries. These include more than 1,200 in Egypt, where the company has had a manufacturing site in Cairo since 1962 that currently produces over 120 million units of medicine per year. With primary focus is on patient needs. We provide integrated healthcare solutions through world-class medicines covering a vast array of diseases, innovative healthcare products, vaccines, and healthcare services. We also aim to lower the risks of disease onset, and facilitate early diagnosis. About Minapharm Pharmaceuticals Minapharm Pharmaceuticals is a leading pharmaceutical company in Egypt and the Middle East and the premier biopharmaceutical company in Africa with over 20 years of experience in cellular and bioprocess engineering. Headquartered in Cairo, Minapharm commercializes over 100 life-saving and life-enhancing products ranging from small molecules to complex genetically-engineered proteins, with an impressive immunotherapy pipeline. Together with its wholly owned Berlin-based subsidiary, ProBioGen AG, Minapharm has established an integrated business model making it to-date the only gene-to-market biopharmaceutical company in the region. Minapharm employs a collective workforce of over 2000 and is listed on the Cairo and Alexandria stock exchange (Symbol: MIPH). Photo - SOURCE Minapharm Pharmaceuticals

--CM-101's Unique Dual Anti-Fibrotic and Anti-Inflammatory Activity Supports Its Disease Modifying Potential in Primary Sclerosing Cholangitis (PSC)--- --CM-101 Phase 2 SPRING Trial in PSC is Advancing Towards Completion of Enrollment with Topline Readout Currently Targeted in Second Half of 2024-- TEL AVIV, Israel, Sept. 28, 2023 /PRNewswire/ -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical stage biotechnology company developing innovative therapeutics to treat rare fibro-inflammatory diseases with high unmet need, today announced that Chemomab co-founder, Chief Executive Officer and Chief Scientific Officer Adi Mor, PhD, will discuss the CM-101 clinical program in primary sclerosing cholangitis (PSC) at the 2023 Roth MKM Healthcare Opportunities Conference on October 12, 2023. The conference is being held at the Yale Club in New York City. Dr. Mor will give a live presentation at 12:00 noon ET and company executives will participate in one-on-one meetings with investors. Chemomab's first-in-class monoclonal antibody CM-101 neutralizes CCL24, a novel target that has been shown to play a central role in the processes that drive fibrosis and inflammation. CM-101 is currently being assessed in the Phase 2 SPRING trial for the treatment of PSC, with topline data expected in the second half of 2024. PSC is a potentially lethal condition that lacks any FDA-approved therapies and frequently requires liver transplant. Unlike the other drugs in clinical development for PSC, CM-101 has a unique dual mechanism of action that simultaneously blocks fibrosis and inflammation. In extensive preclinical and early clinical studies, this distinctive, multifaceted approach has been shown to inhibit fibrogenesis and interfere with the core pathways that result in the liver damage associated with PSC. Earlier this year, Chemomab reported positive results from a Phase 2a liver fibrosis trial in patients with nonalcoholic steatohepatitis (NASH). A majority of patients treated with CM-101 demonstrated improvements in multiple biomarkers associated with fibrosis and inflammation. A higher percentage of patients responding to treatment with CM-101 had improvements in Enhanced Liver Fibrosis (ELF) scores, liver stiffness as measured by transient elastography, and PRO-C3 levels compared to placebo. The ELF score, liver stiffness as measured by transient elastography and PRO-C3, a marker of collagen III formation, have all been identified as prognostic markers and independent predictors of transplant-free survival and improved patient outcomes in PSC. These results suggest that CM-101 possesses anti-fibrotic properties in the liver that may also be relevant in PSC, and Chemomab views these data as promising for a potentially successful translation to the treatment of PSC. The company's ongoing PSC Phase 2 SPRING trial is evaluating two dose cohorts that are intended to provide high exposure to CM-101 (10 and 20mg/kg intravenously administered, compared to 5mg/kg via subcutaneous injection in the liver fibrosis/NASH trial), as well as an open-label extension providing for longer-term evaluation of the effects of CM-101 treatment for up to 48 weeks, thereby enhancing the opportunity for a more comprehensive assessment of CM-101's therapeutic potential in PSC. "We have reported a number of positive CM-101 developments this year," said Dr. Mor. "First, we reported consistent, positive biomarker data from our Phase 2 liver fibrosis trial in NASH patients that we believe are directly relevant to PSC; second, we presented several supportive preclinical PSC studies at major scientific meetings and published a peer-reviewed scientific review of the role of CCL24 in PSC; and third, the strong commitment of PSC patients and clinicians to the Phase 2 SPRING trial is enabling us to advance enrollment at a robust pace." Dr. Mor added, "We consider the recent announcement of promising results in Pliant's Phase 2 PSC study as a positive for the field, highlighting the unmet need in PSC and the possible utility of anti-fibrotic agents in this condition. Our continued clinical progress in validating CM-101's unique dual anti-inflammatory and anti-fibrotic activity reinforces our optimism that CM-101 may have potential as a disease-modifying therapy for PSC. We look forward to discussing the CM-101 PSC program at the upcoming Roth MKM conference as we advance towards completing our Phase 2 trial and reporting topline results in the coming year." Attendance at the conference is by invitation only. To register for the 2023 Roth-MKM Healthcare Opportunities Conference, click here, or contact a Roth MKM sales representative. About CM-101 CM-101 is a monoclonal antibody that neutralizes CCL24, a soluble protein that helps drive the inflammatory and fibrotic pathways central to many fibro-inflammatory diseases. CCL24's role as a therapeutic target has been validated in extensive preclinical studies and Chemomab researchers have demonstrated preclinical proof-of-concept for CM-101 in multiple animal and patient sample studies. CM-101 was safe and well tolerated in Phase 1 and Phase 2 clinical trials to date. In a Phase 1b study it improved liver biomarkers, decreased liver stiffness and demonstrated a favorable PK and target engagement profile in patients with nonalcoholic fatty liver disease (NAFLD). Data from a completed Phase 2a liver fibrosis trial in NASH patients (NCT05824156) reported earlier this year showed consistent, positive improvements in key inflammatory and fibrogenesis-related biomarkers, including several that may serve as a potential bridge to activity in PSC. CM-101 is currently being evaluated in PSC patients in the Phase 2 SPRING trial (NCT04595825), with a topline readout expected in the second half of 2024. About Chemomab Therapeutics Ltd. Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique and pivotal role of CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody designed to neutralize CCL24 activity. In preclinical and clinical studies, CM-101 appears safe, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported encouraging results from three clinical trials of CM-101 in patients, including a Phase 1b trial in NAFLD patients, a Phase 2 liver fibrosis trial in NASH patients and an investigator-initiated study in patients with severe lung injury. The CM-101 program for the treatment of systemic sclerosis is Phase 2-ready and a Phase 2 trial in primary sclerosing cholangitis patients is ongoing, with topline data expected in the second half of 2024. For more information about Chemomab, visit chemomab.com. Forward Looking Statements This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act. These forward-looking statements include, among other things, statements regarding the clinical development pathway for CM-101; the future operations of Chemomab and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones; the Company's cash position and expectations regarding its ability to achieve the topline data readout from the Phase 2 primary sclerosing cholangitis (PSC) trial of CM-101 with its current cash; the nature, strategy and focus of Chemomab; the development and commercial potential and potential benefits of any product candidates of Chemomab; and that the product candidates have the potential to address high unmet needs of patients with serious fibrosis-related diseases and conditions. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon Chemomab's current expectations. Forward-looking statements involve risks and uncertainties. Because such statements deal with future events and are based on Chemomab's current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Chemomab could differ materially from those described in or implied by the statements in this presentation, including those found under the caption "Risk Factors" and elsewhere in Chemomab's filings and reports with the SEC. Chemomab expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Chemomab's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based, except as required by law. Contacts: Media and Investors: Barbara Lindheim Consulting Vice President, Investor & Public Relations, Strategic Communications Phone: +1 917-355-9234 [email protected] [email protected] SOURCE Chemomab Therapeutics, Ltd.