KNG1

Astria Therapeutics Announces Publication of STAR-0215 Preclinical Data in the Journal of Pharmacology and Experimental Therapeutics BOSTON--(BUSINESS WIRE)-- Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company developing STAR-0215 for the treatment of hereditary angioedema (HAE) and focused on life-changing therapies for rare and niche allergic and immunological diseases, today announced that preclinical data supporting STAR-0215’s pro a potential long-acting therapy for hereditary angioedema (HAE) dosed once every three or six months has been published in the Journal of Pharmacology and Experimental Therapeutics. “We were very pleased by our publication in the Journal of Pharmacology and Experimental Therapeutics, further validating the exciting science behind STAR-0215,” said Jill C. Milne, Ph.D., Chief Executive Officer at Astria Therapeutics. “These results demonstrate that STAR-0215 is a potential best-in-class plasma kallikrein inhibitor as it shows high potency in vitro and in vivo and long half-life, suggesting potential for sustained, durable HAE attack suppression with subcutaneous administration.” Overview of STAR-0215 Preclinical Results: STAR-0215’s YTE modification in the Fc domain enhances FcRn receptor binding, resulting in a ~3-fold prolonged half-life in cynomolgus monkeys compared to antibodies without this modification. STAR-0215 has a >1000-fold lower affinity for prekallikrein and no measurable inhibitory activity against other serine proteases, demonstrating potent and specific binding for STAR-0215 for human plasma kallikrein. STAR-0215 demonstrated potent in vitro inhibition of plasma kallikrein-mediated bradykinin release from high molecular weight kininogen (HWMK) in a physiologically relevant assay. STAR-0215 achieved inhibition of cleaved HMWK (cHMWK) in cynomolgus monkeys within one day after dosing. This inhibition was sustained throughout the duration of the study, including an 84-day dose-free period, demonstrating both rapid and long-lasting inhibition of plasma kallikrein achievable by subcutaneous administration. The publication can be found at the following link: STAR-0215 is a monoclonal antibody inhibitor of plasma kallikrein in development for the treatment of HAE. Initial results from a Phase 1a trial in healthy subjects support STAR-0215’s target profile: a long-acting preventative therapy, best-in-class pharmacokinetic (PK) profile, and dosing once every three or six months. Final results from these three cohorts, as well as initial results from two additional cohorts, are anticipated in the fourth quarter of 2023. The Phase 1b/2 ALPHA-STAR trial evaluating STAR-0215 in people living with HAE is ongoing, with initial proof-of-concept results from single and multiple dose cohorts expected in mid-2024. About Astria Therapeutics: Astria Therapeutics is a biopharmaceutical company, and our mission is to bring life-changing therapies to patients and families affected by rare and niche allergic and immunological diseases. Our lead program, STAR-0215, is a monoclonal antibody inhibitor of plasma kallikrein in clinical development for the treatment of hereditary angioedema. Learn more about our company on our website, , or follow us on Twitter and Instagram @AstriaTx and on Facebook and LinkedIn. Forward Looking Statements: This press release contains forward-looking statements within the meaning of applicable securities laws and regulations including, but not limited to, statements regarding: expectations regarding the timing and nature of additional results from the ongoing STAR-0215 Phase 1a clinical trial; the timing and nature of the anticipated proof of concept results from the ALPHA-STAR Phase 1b/2 clinical trial; the potential attributes and differentiated pro STAR-0215 as a treatment for HAE, and our vision for STAR-0215 as a treatment for HAE; the need for effective treatments for HAE; the potential for three and six-month administration of STAR-0215; and our goal to meet the unmet needs of patients with rare and niche allergic and immunological diseases. The use of words such as, but not limited to, “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “goals,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” and similar words expressions are intended to identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on the Company’s current beliefs, expectations and assumptions regarding the future of its business, future plans and strategies, future financial performance, results of pre-clinical and clinical results of the Company’s product candidates and other future conditions. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including risks and uncertainties: changes in applicable laws or regulations; the possibility that we may be adversely affected by other economic, business, and/or competitive factors, including the COVID-19 pandemic; risks inherent in pharmaceutical research and development, such as: adverse results in our drug discovery, preclinical and clinical development activities, the risk that the results of pre-clinical studies may not be replicated in clinical studies, that the preliminary results from the Phase 1a trial may not be indicative of the final results, that the results of early stage clinical studies, such as the preliminary and initial unblinded results from the Phase 1a trial, may not be replicated in later stage clinical studies, including the ALPHA-STAR trial, the risk that we may not be able to enroll sufficient patients in our clinical trials on a timely basis, and the risk that any of our clinical trials may not commence, continue or be completed on time, or at all; decisions made by, and feedback received from, the FDA and other regulatory authorities on our regulatory and clinical trial submissions and other feedback from potential clinical trial sites, including investigational review boards at such sites, and other review bodies with respect to STAR-0215 and any other future development candidates; the risk that we do not realize some or all of the potential benefits of STAR-0215's Fast Track designation; our ability to manufacture sufficient quantities of drug substance and drug product for STAR-0215 and any other future product candidates on a cost-effective and timely basis, and to develop dosages and formulation for STAR-0215 and any other future product candidates that are patient-friendly and competitive; our ability to develop biomarker and other assays, along with the testing protocols therefore; our ability to obtain, maintain and enforce intellectual property rights for STAR-0215 and any other future product candidates; our potential dependence on collaboration partners; competition with respect to STAR-0215 or any of our other future product candidates; the risk that the clinical results to date, survey results and market research may not be accurate predictors of the commercial landscape for HAE, the ability of STAR-0215 to compete in HAE and the anticipated position and attributes of STAR-0215 in HAE based on its clinical data to date, pre-clinical profile, mechanistic and other modeling, market research, patient feedback and other data; our ability to manage our cash usage and the possibility of unexpected cash expenditures; our ability to obtain necessary financing to conduct our planned activities and to manage unplanned cash requirements; the risks and uncertainties related to our ability to recognize the benefits of any additional acquisitions, licenses or similar transactions; and general economic and market conditions; as well as the risks and uncertainties discussed in the “Risk Factors” section of our Annual Report on Form 10-K for the period ended December 31, 2022 and in other filings that we make with the Securities and Exchange Commission (“SEC”). New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. The Company may not actually achieve the forecasts or expectations disclosed in our forward-looking statements, and investors and potential investors should not place undue reliance on the Company’s forward-looking statements. Neither the Company, nor its affiliates, advisors or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as result of new information, future events or otherwise, except as required by law. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date hereof.

The Company announced the development of the first antiviral to combat BK virus, one of the most common viral infections in transplant patients CANTON, Mass.--(BUSINESS WIRE)-- Orthogon Therapeutics LLC, a trailblazer in the field of antiviral therapeutics, today announced a dual victory. Orthogon’s lead molecule has successfully completed acute toxicity studies, marking a pivotal technical milestone that has unlocked an additional $3M from its dedicated syndicate of healthcare investors. This wraps up a $6M financing over the past year and brings Orthogon's total raise to a formidable $18.5M. "We're celebrating this scientific achievement as much as this new funding," said Dr. Ali H. Munawar, CEO of Orthogon Therapeutics. "Our team's unwavering efforts and ingenuity have led us to these important wins. These achievements bring us one step closer to delivering the first-ever treatment for BK virus." Dr. Munawar added, “The real breakthrough in truly preventing, managing, and treating BK virus will come with a versatile, small molecule that targets BK virus at the site of replication. One that offers dosing flexibility in both at-risk patients and those already experiencing BK virus reactivation. This therapeutic option is non-existent, but the landscape is about to be transformed.” BK virus presents a substantial threat to immunocompromised patients, especially transplant recipients. With no current treatment options available, Orthogon’s groundbreaking work is poised to deliver a first-of-its-kind solution. “Once again, our backers have demonstrated their belief in our technology platform and in our mission to develop innovative treatment options for transplant patients,” remarked Dr. Munawar. This development serves as a major catalyst, propelling Orthogon’s pioneering drug candidate into pre-IND studies and moving it closer to the clinic. About Orthogon Therapeutics: Orthogon Therapeutics, LLC is a privately held R&D firm headquartered in the biotech hub of Greater Boston with a branch in Leuven, Belgium. Orthogon wields an innovative structure-based and biophysics platform for the design of novel medicines. About BK and polyomaviruses: BK virus (BKV), a member of the polyomavirus family, establishes a life-long, persistent yet silent infection in over 80% of healthy adults. BK virus reactivation is seen in the kidneys of nearly half of all solid organ and stem cell transplant patients, leading to severe complications and graft loss.

Riparian Pharmaceuticals' therapeutic programs are designed to target key vasoprotective pathways. Pfizer has licensed a preclinical cardiovascular program from Riparian Pharmaceuticals as part of an agreement that will also see the Big Pharma support further discovery efforts by the biotech. Even for a licensing announcement, this morning’s release was light on details—while there will be upfront and milestone payments attached, the amounts weren’t disclosed. All we know for sure is that Pfizer has gained the exclusive rights to one unnamed preclinical program. “As part of the research agreement, Pfizer will support Riparian’s efforts to discover further drug targets leading to vasoprotection and will have an option on such targets,” according to the announcement.  “I am incredibly proud of the entire Riparian team and their success translating fascinating science into an innovative therapeutic program,” Riparian CEO Will Adams, Ph.D., said in this morning’s release. “We are excited to collaborate with Pfizer and believe they are the ideal partner to advance this program and develop impactful therapies.” Privately owned Riparian’s therapeutic programs are designed to target “key vasoprotective pathways” with the aim of reducing both vascular inflammation and a type of nonobstructive coronary artery disease called endothelial dysfunction. The company has raised more than $10 million in grants and financing to date, according to Riparian’s website, which gives little else away about the biotech’s pipeline. Pfizer has been quiet on the cardiovascular front in recent years. As part of its $6.7 billion acquisition of Arena Pharmaceuticals in 2021, it acquired a couple of phase 2 assets in the form of a beta-3 adrenergic receptor antagonist for acute heart failure and temanogrel, which was being trialed for microvascular obstruction. But the Big Pharma revealed a few months ago that it had canned both candidates. That still leaves ponsegromab, a growth differentiation factor 15 monoclonal antibody in phase 2 trials for heart failure, and PF-07328948, a BDK inhibitor in phase 1 for heart failure with preserved ejection fraction. Pfizer also markets Vyndaqel, which is indicated for a rare disease called transthyretin amyloidosis in patients with transthyretin amyloidosis with cardiomyopathy, among others. Riparian's announcement comes a day after Pfizer unveiled a more ambitious pact with Flagship Pioneering to work on 10 programs, for which the Big Pharma and the VC firm will each lay down $50 million at the outset. While the targets have yet to be decided, they will address unmet needs within Pfizer’s core strategic areas of interest—vaccines, inflammation/immunology, oncology, rare diseases and internal medicine.