adrenergic receptor x TYMS

Last update 01 Nov 2024

Basic Info

Related Targets

adrenergic receptorTYMS

Drugs associated with adrenergic receptor x TYMS

Fluorouracil/Adrenaline

Target

TYMS x adrenergic receptor

Mechanism

TYMS inhibitors [+1]

Active Org.-

Originator Org.

Chiron Corp.

Active Indication-

Inactive Indication

Basal Cell Carcinoma [+4]

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with adrenergic receptor x TYMS

100 Translational Medicine associated with adrenergic receptor x TYMS

0 Patents (Medical) associated with adrenergic receptor x TYMS

Literatures (Medical) associated with adrenergic receptor x TYMS

01 Sep 1994·Biochemistry and molecular biology international

Regulation of thymidylate synthase in regenerating rat liver after partial hepatectomy.

Article

Author: Wakabayashi, M ; Nakata, R ; Tsukamoto, I

Level of thymidylate synthase (TS) mRNA elevated about 6-fold compared with the normal in 24 h-regenerating rat liver after partial hepatectomy. This elevation of TS mRNA level was coupled with that of the activity. After 24h, the TS mRNA level began to decline steeply and returned to the normal level at 72h, when TS activity remained at the maximal level. alpha-Adrenergic regulation of liver regeneration after partial hepatectomy, which was shown in our previous paper, was found to be occurred at mRNA level of TS. The administration of cycloheximide resulted in the decreases of both TS activity and TS mRNA level while actinomycin D had no effect. This suggested that the increase of TS mRNA in regenerating liver required the de novo synthesis of some activator protein(s).

01 Feb 1988·Biochimica et Biophysica Acta (BBA) - General Subjects

A new immunoblotting assay for thymidylate synthetase and its application to the regulation of enzyme activity in regenerating rat liver

Article

Author: Shosuke Kojo ; Rieko Nakata ; Shigeru Taketani ; Masamitsu Miyoshi ; Ikuyo Tsukamoto

A highly sensitive and specific immunoblot assay has been developed to quantitate the content of rat liver thymidylate synthetase (EC 2.1.1.45). Applying the method, it is demonstrated that the increase of the activity of thymidylate synthetase in liver regeneration after partial hepatectomy is due to the de novo synthesis of the enzyme protein. Administration of cycloheximide, phenoxybenzamine, phorbol 12-myristate 13-acetate, nifedipine, dexamethasone or indomethacin to partially hepatectomized rats prevented the synthesis of thymidylate synthetase in regenerating liver. Thyroparathyroidectomy also inhibited the increase of the enzyme in liver regeneration. These observations are discussed in relation to the signal transduction concerning the alpha 1-receptor, which was shown to regulate liver regeneration in our previous papers.

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