Last update 01 Nov 2024

TBX19

Last update 01 Nov 2024

Basic Info

Synonyms

dj747L4.1, T-box factor, pituitary, T-box protein 19

+ [4]

Introduction

Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.

Drugs associated with TBX19

CN115850468

Patent Mining

Target

TBX19

Mechanism-

Active Org.

Fuzhou Maixin Biotech Co., Ltd.

Originator Org.

Fuzhou Maixin Biotech Co., Ltd.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with TBX19

100 Translational Medicine associated with TBX19

0 Patents (Medical) associated with TBX19

201

Literatures (Medical) associated with TBX19

01 Oct 2024·Proceedings of the National Academy of Sciences

Paracrine FGF1 signaling directs pituitary architecture and size

Article

Author: Khetchoumian, Konstantin ; Gouhier, Arthur ; Kherdjemil, Yacine ; Lafont, Chrystel ; Le Tissier, Paul ; Kmita, Marie ; Bemmo, Amandine ; Sochodolsky, Kevin ; Drouin, Jacques ; Mollard, Patrice ; Christian, Helen

Organ architecture is established during development through intricate cell–cell communication mechanisms, yet the specific signals mediating these communications often remain elusive. Here, we used the anterior pituitary gland that harbors different interdigitated hormone-secreting homotypic cell networks to dissect cell–cell communication mechanisms operating during late development. We show that blocking differentiation of corticotrope cells leads to pituitary hypoplasia with a major effect on somatotrope cells that directly contact corticotropes. Gene knockout of the corticotrope-restricted transcription factor Tpit results in fewer somatotropes, with less secretory granules and a loss of cell polarity, resulting in systemic growth retardation. Single-cell transcriptomic analyses identified FGF1 as a corticotrope-specific Tpit dosage-dependent target gene responsible for these phenotypes. Consistently, genetic ablation of FGF1 in mice phenocopies pituitary hypoplasia and growth impairment observed in Tpit -deficient mice. These findings reveal FGF1 produced by the corticotrope cell network as an essential paracrine signaling molecule participating in pituitary architecture and size.

01 Sep 2024·Virchows Archiv

PIT-EASY survey: validation of the European Pituitary Pathology Group proposal for reporting pituitary neuroendocrine tumors

Article

Author: Asioli, Sofia ; Vasiljevic, Alexandre ; Boulagnon-Rombi, Camille ; Perbet, Romain ; Gauchotte, Guillaume ; Baussart, Bertrand ; Sturm, Nathalie ; Maurage, Claude-Alain ; Birtolo, Maria Francesca ; Bertherat, Jérôme ; Bousdira, Ghizelaine ; Tetka, Louise Marie Mboua ; Brue, Thierry ; Roncaroli, Federico ; Figarella-Branger, Dominique ; Villa, Chiara ; Appay, Romain ; Jouinot, Anne

The aim of this multicenter prospective survey called PIT-EASY was to assess the relevance of the European Pituitary Pathology Group (EPPG) diagnostic tools for pituitary neuroendocrine tumors (PitNETs) to improve the quality of their histological diagnosis. Each center performed at least 30 histological cases of PitNETs using the EPPG tools and assessed their value using a scorecard with 10 questions. For each center, the histological cases were carried out by pathologists with varying levels of expertise in pituitary pathology defined as junior, intermediate, and expert. Two hundred and ninety histological cases were collected from six French and Italian centers. The three EPPG tools were validated and regarded as helpful for a more accurate and time-efficient diagnosis. The usefulness of level 2 and level 3 of the "EPPG's multi-step approach for immunohistochemistry" including pituitary transcription factors (PIT1, TPIT, and SF1) and chromogranin, SSTRs, and P53 respectively was higher in "other non-functioning" (silent plurihormonal PIT1, silent corticotroph, and null cell): 88% vs 32%, p < 10-6 and 42% vs 14%, p = 0.002, respectively. The diagnostic algorithm proved more useful for junior pathologists (p = 0.0001) and those with intermediate experience. PIT-EASY survey confirmed the importance of a standardized approach to PitNETs for an accurate and reproducible diagnosis and served as validation of the EPPG proposal. The tool appeared to be of practical value to junior participants and staff with intermediate experience for safe routine diagnostic reporting.

01 Sep 2024·Endocrine Pathology

Granulation Patterns of Functional Corticotroph Tumors Correlate with Tumor Size, Proliferative Activity, T2 Intensity-to-White Matter Ratio, and Postsurgical Early Biochemical Remission

Article

Author: Kefeli, Mehmet ; Mete, Ozgur ; Durmuş, Elif Tutku ; Durmuş, Buğra ; Onar, Mustafa Arda ; Cokluk, Cengiz ; Çolak, Ramis ; Çalışkan, Sultan ; Aslan, Kerim ; Atmaca, Ayşegül

AbstractUnlike somatotroph tumors, the data on correlates of tumor granulation patterns in functional TPIT lineage pituitary neuroendocrine tumors (corticotroph tumors) have been less uniformly documented in most clinical series. This study evaluated characteristics of 41 well-characterized functional corticotroph tumors consisting of 28 densely granulated corticotroph tumors (DGCTs) and 13 sparsely granulated corticotroph tumors (SGCTs) with respect to preoperative clinical and radiological findings, tumor proliferative activity (including mitotic count and Ki-67 labeling index), and postoperative early biochemical remission rates. The median (interquartile range (IQR)) tumor size was significantly larger in the SGCT group [16.00 (16.00) mm in SGCT vs 8.5 (9.75) mm in DGCT, p = 0.049]. T2-weighted signal intensity and T2 intensity (quantitative) did not yield statistical significance based on tumor granulation; however, the T2 intensity-to-white matter ratio was significantly higher in SGCTs (p = 0.049). The median (IQR) Ki-67 labeling index was 2.00% (IQR 1.00%) in the DGCT group and 4.00% (IQR 7.00%) in the SGCT group (p = 0.043). The mitotic count per 2 mm2 was higher in the SGCT group (p = 0.001). In the multivariate analysis, the sparse granulation pattern (SGCT) remained an independent predictor of a lower probability of early biochemical remission irrespective of the tumor size and proliferative activity (p = 0.012). The current study further supports the impact of tumor granulation pattern as a biologic variable and warrants the detailed histological subtyping of functional corticotroph tumors as indicated in the WHO classification of pituitary neuroendocrine tumors. More importantly, the assessment of the quantitative T2 intensity-to-white matter ratio may serve as a preoperative radiological harbinger of SGCTs.

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TBX19

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