Biological Glossary | What is Coding Sequence (CDS)?

A coding sequence (CDS) is a portion of a gene or an mRNA molecule that specifically codes for a protein. Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to non-coding regions over different species and time periods can provide a significant amount of important information regarding gene organization and evolution of prokaryotes and eukaryotes. Introns are not coding sequences; nor are the 5' or 3' untranslated regions (or the flanking regions, for that matter - they are not even transcribed into mRNA). This sequence includes a series of codons, which are triplets of nucleotides that specify which amino acids need to be included in the protein during synthesis. Usually, a CDS starts with a start codon (ATG in DNA or AUG in RNA) and ends with a stop codon.

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