Bio Sequence

What Retrieval Methods Can be Used in the CAR-T Field to Find More Comprehensive Technical Materials and Patent Information? (Part II)

12 December 2023
3 min read

In the CAR-T field, we can perform comprehensive data retrieval of CAR-T in two major parts: antibody search and CAR expression cassette design.

Antibody Search: To enable CAR-T to reach its target successfully, choosing the appropriate antigen recognition domain is essential. 

CAR Expression Cassette: The design of the CAR expression cassette determines whether a T cell can become CAR-T and the effect it produces.

The previous content thoroughly explained the retrieval strategy for the antibody searching section: What Retrieval Methods Can Be Used in the CAR-T Field to Find More Comprehensive Technical Materials and Patent Information? (Part 1). In this content, we mainly discuss the search for the CAR expression cassette. Data retrieval can be done primarily through the following aspects:

Sequences Search——based on the drug sequence, similar sequences are retrieved, also searching related patents and literature information.

Fragment retrieval——supports searching for related sequences based on core components of CAR-T.

Combined searching——searching for patents containing multiple sequences at once.

Let’s look at the specific retrieval methods:

I. Cases where the core functional elements of CAR in the patent are written in one sequence.

One can take advantage of the fragment search function of the Bio database for retrieval. Firstly, register a Patsnap Bio Sequence Database account for free. Then, enter the whole sequence of Tisagenlecleucel into the fragment search function on the database homepage, and choose the multi-segment fragment (currently supporting a maximum selection of 10 segments) in the options on the right. We assign the starting and termination points of the Hing, Transmembrane, and Intracellular sections, respectively. Click search, and you can look up the related sequence results of the three core functional components of Tisagenlecleucel.

图形用户界面, 文本, 应用程序, 电子邮件

描述已自动生成

图形用户界面, 文本, 应用程序, 电子邮件

描述已自动生成

II. Cases where the core functional elements of CAR in the patents are written separately.

The combined search function of the Bio database can be utilized for retrieval, searching for patents that simultaneously release combinations of multiple sequences based on the CAR-T core functional elements in the patents, such as the antigen-recognizing area, hinge region, transmembrane region, and intracellular structure domain, etc. We input the three parts of Tisagenlecleucel’s Hing, Transmembrane, and Intracellular separately into the search box (supporting a maximum of 6 sequence combinations for now) and then click search to view the heat map of patents that release the three sequences at once and then further enter the patent to view the details. In the combined search's result filtering options, we can customize 1-3 sequence combinations to view the results you want precisely.

图形用户界面, 文本, 应用程序, 电子邮件

描述已自动生成

图形用户界面, 应用程序

描述已自动生成

The aforementioned are all ways to retrieve sequences of patents, literature, and other technical data in the CAR-T field. 

Regardless of whether you are personnel conducting patentability analysis and FTO work for CAR-T output sequences or personnel who are engaged in CAR-T drug development research and development, you can consult and verify the respective patent technical information accurately and comprehensively in the Patsnap Bio sequence database utilizing various retrieval functions and methods.

It is important to note that Patsnap Bio is the most extensive sequence search platform for the Patsnap database. It incorporates AI with human-curated data for comprehensive handling of protein and nucleotide sequence data plucked from global patents, biological periodicals, and public repositories. Essential biological sequences are manually annotated, illuminating structural modifications to provide the most accurate sequence data and boost sequence retrieval efficiency.

Free registration is available for the Bio biological sequence database: https://bio-patsnap-com.libproxy1.nus.edu.sg. Act now to expedite your sequence search tasks.

Sana Biotech's SC291, an off-the-shelf CAR T targeting CD19, undetected by immune system in initial clinical results
Latest Hotspot
3 min read
Sana Biotech's SC291, an off-the-shelf CAR T targeting CD19, undetected by immune system in initial clinical results
12 December 2023
Sana Biotechnology Releases Initial Clinical Findings Demonstrating SC291, an Off-the-Shelf CAR T Treatment Targeting CD19, Remains Undetected by a Functional Immune System.
Read →
Benitec Biopharma begins early trial dosing for BB-301, its genetic therapy for Oculopharyngeal Muscular Dystrophy
Latest Hotspot
3 min read
Benitec Biopharma begins early trial dosing for BB-301, its genetic therapy for Oculopharyngeal Muscular Dystrophy
8 December 2023
Benitec Biopharma has reported initial dosing in an early-stage trial for its genetic treatment prospect, BB-301, aimed at tackling Oculopharyngeal Muscular Dystrophy.
Read →
What are Nrf2 inhibitors and how do you quickly get the latest development progress?
What are Nrf2 inhibitors and how do you quickly get the latest development progress?
8 December 2023
Nrf2 inhibitors are compounds that target the Nrf2 transcription factor, crucial for defense against oxidative stress.
Read →
Ambrx Reports Advances in APEX-01, Phase 1/2 Trial of ARX517, a PSMA-Targeted ADC, in Hormone-Refractory Advanced Prostate Cancer
Latest Hotspot
3 min read
Ambrx Reports Advances in APEX-01, Phase 1/2 Trial of ARX517, a PSMA-Targeted ADC, in Hormone-Refractory Advanced Prostate Cancer
8 December 2023
Ambrx Reports Progress on APEX-01 Trial, a Phase 1 / 2 Study Assessing Increasing Doses of ARX517, Its Own PSMA-Directed Antibody-Drug Conjugate, in Advanced Prostate Cancer Unresponsive to Hormonal Therapy.
Read →
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.