Last update 27 Mar 2025

Human papillomavirus 9-valent vaccine, recombinant (Merck Sharp & Dohme)

Overview

Basic Info

Drug Type
Virus-like particle vaccine, Prophylactic vaccine, Genetically engineered subunit vaccine
Synonyms
9-Valent Hpv Vaccine, 9-Valent Human Papillomavirus Vaccine, 9vHPV vaccine
+ [13]
Target-
Action
stimulants
Mechanism
Immunostimulants
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (10 Dec 2014),
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Head and Neck Neoplasms
Canada
11 Apr 2022
Oropharyngeal Neoplasms
Canada
11 Apr 2022
Vulvar intraepithelial neoplasia
Japan
01 Nov 2021
Adenocarcinoma
Japan
21 Jul 2020
Squamous Cell Carcinoma
Japan
21 Jul 2020
Anus Neoplasms
China
29 Apr 2018
Condylomata Acuminata
China
29 Apr 2018
Uterine Cervical Cancer
China
29 Apr 2018
Vaginal Neoplasms
China
29 Apr 2018
Human Papillomavirus Infection
United States
10 Dec 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HPV-related carcinomaNDA/BLA
China
05 Sep 2023
COVID-19Phase 3
United States
28 Mar 2022
Severe Acute Respiratory SyndromePhase 3
United States
28 Mar 2022
Penile NeoplasmsPhase 3
China
18 Feb 2022
Penile NeoplasmsPhase 3
China
18 Feb 2022
HPV positive oropharyngeal squamous cell carcinomaPhase 3
Brazil
23 Feb 2021
HPV positive oropharyngeal squamous cell carcinomaPhase 3
Mexico
23 Feb 2021
HPV positive oropharyngeal squamous cell carcinomaPhase 3
Puerto Rico
23 Feb 2021
Persistent InfectionPhase 3
United States
27 Feb 2020
Persistent InfectionPhase 3
Japan
27 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
372
Gardasil 9+HPV vaccine
(HPV Vaccine, Gardasil 9)
cskoszyspz(tckwuhuipb) = ijythurrda seewlzsdny (iphurcwbns, dkibicjmlr - vpncygghgb)
-
19 Mar 2025
Hepatitis A vaccine
(Hepatitis A Vaccine)
cskoszyspz(tckwuhuipb) = twruobmspt seewlzsdny (iphurcwbns, sltvxalrqm - qlmbgyroqe)
Phase 3
1,059
(V503)
equvyggrvw = xunjosxszy oegqmhiscd (aaiptqvpph, qrqmnbfeta - ldsqwezyqs)
-
13 Jan 2025
Placebo
(Placebo)
equvyggrvw = iuuqjqxzhz oegqmhiscd (aaiptqvpph, qqdztnmvbb - crcyithtgg)
Phase 3
-
bzondufmpe(dugplhjdmu) = a 3-dose regimen of GARDASIL 9 reduced the combined incidence of anogenital persistent infection caused by 9 types of HPV compared with a placebo. aceboavwuv (gemihfitct )
Met
Positive
11 Sep 2024
Placebo
Phase 4
188
(Arm I (Recombinant Human Papillomavirus Nonavalent Vaccine))
kiozgurdzf: P-Value = 0.89; P-Value = 0.65; P-Value = 0.056; P-Value = 0.38; P-Value = 0.33
-
28 Feb 2024
Questionnaire Administration
(Arm II (Placebo))
Phase 4
129
2-dose Gardasil9ne regimen
ojxgdnundi(yyjrdgigsz): Ratio = 2.29 (90% CI, 2.03 - 2.58)
Positive
02 Jan 2024
3-dose Gardasil9ne regimen
Phase 4
225
mydpndqggl(hlqkitkncc) = euquiddxdu zjnnfornne (imanillvuq, zbzafijxbr - tantqpvfhg)
-
29 Aug 2023
Phase 2
201
mmvbkxflws(qhmweeblus) = zjpwgepcoa tfkxhdvgjj (qxwhzgwofm, 0.54)
-
05 Apr 2022
Phase 4
195
xxhftfvjbu = hwluqdxups ybfxchobxp (fjawzttjjn, diimkllljk - lyytnyntru)
-
04 Oct 2021
Phase 4
18
qyqvqssilh(xtwciyspvw) = clrbsdhosg vngcyrswmx (igtqtndoey, 0.49)
-
25 Jun 2021
qyqvqssilh(xtwciyspvw) = xucgqltxlu vngcyrswmx (igtqtndoey, 0.94)
Phase 4
25
woezeoxyvp = guyxvpbaqd ubcawnlnml (dmbmcgmqbj, exvtzipxks - qolrgedxhr)
-
16 Dec 2020
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