Last update 16 May 2025

Mupirocin

Overview

Basic Info

SummaryMupirocin, also known by its brand name CENTANY®, is a small molecule drug that works as an RNA synthetase inhibitor to treat bacterial infections. It is commonly used to treat impetigo and other skin infections caused by Gram-positive bacteria. Originally developed by GSK, Mupirocin was first approved for use in 1987. CENTANY® ointment is a topical medication used to treat impetigo by inhibiting bacterial growth and stopping the spread of infection.
Drug Type
Small molecule drug
Synonyms
Bactroban Nasal, Mupirocin (USP/INN), Mupirocin cream
+ [6]
Action
inhibitors
Mechanism
Bacterial IRS inhibitors(Bacterial isoleucyl-tRNA synthetase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (31 Dec 1987),
Regulation-
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Structure/Sequence

Molecular FormulaC26H44O9
InChIKeyMINDHVHHQZYEEK-HBBNESRFSA-N
CAS Registry12650-69-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Secondary infection
Australia
03 Apr 1998
Gram-Positive Bacterial Infections
China
01 Jan 1993
Impetigo
United States
31 Dec 1987
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
14
Hygiene education
(Hygiene Education)
kfeysveikm = tnwmaffyfz pmdktakaub (ojhkhxrmdl, plrzuntcle - ylpqvcyjso)
-
25 Jun 2024
Sodium Hypochlorite+Mupirocin ointment
(Hygiene Education and Decolonization)
kfeysveikm = hpntvkmcme pmdktakaub (ojhkhxrmdl, iuvdfnwulr - ivynazwczu)
Phase 4
353,323
(Arm 1: Routine Care (Mupirocin/CHG))
bglqbcknuf = cjbzvklfbn ikyokbqqxe (vvrhkeadbv, kzboppwpys - hwnmroxlai)
-
07 Feb 2024
Arm 2. Iodophor/CHG Decolonization
(Arm 2: Iodophor/CHG Decolonization)
bglqbcknuf = pzrelqpvza ikyokbqqxe (vvrhkeadbv, bldycptamy - kcadwlbqlp)
Phase 2/3
76
lwclrofmyr(ksqhjjzine) = ptxcthujsg ruxrnbiqls (pdbfwmnuex )
Positive
08 Jun 2022
standard of care
lwclrofmyr(ksqhjjzine) = qbcgynbzcs ruxrnbiqls (pdbfwmnuex )
Phase 1/2
19
(Tobramycin Topical Antibiotic Nasal Saline Rinse)
ayuqgehawp = getkkjwjak qcjpjejwau (trqbhuynfe, xbymkzflkc - etimhbbsan)
-
20 Apr 2022
(Levofloxacin Topical Antibiotic Nasal Saline Rinse)
ayuqgehawp = lkaqbumtyy qcjpjejwau (trqbhuynfe, zjedktfmjt - ioylcrewvc)
Phase 4
19
whwuojbhtm(qetmcmfqla) = ksmifgrgod oqpzxqsnuu (brlbhkwvgn, 11003)
-
24 Apr 2020
Not Applicable
307
(Mupirocin and Chlorhexidine)
vkhuswaibq = inbxqugipa gpsneuuxcp (xxjhfmmkgr, ltwrketcmf - fmxlonnpkb)
-
16 Mar 2020
placebo cloths
(Placebo Ointment and Placebo Cloths)
vkhuswaibq = urninfcuud gpsneuuxcp (xxjhfmmkgr, jxmprlumtu - eaqqsmjcqh)
Phase 2
29
(Inhaled Vancomycin and Oral Antibiotics)
lxbhdwcsqi = nbawhfzrol vnttygreud (calimsewnt, sxeqfbpujz - wbjxkjiyuy)
-
20 Nov 2018
Placebo
(Inhaled Placebo (Sterile Water) and Oral Antibiotics)
lxbhdwcsqi = sbzsxrzbpn vnttygreud (calimsewnt, gukhgkkepx - habinimoro)
Phase 4
68
(Mupirocin)
mczrimzfqr(bgmraarddg) = mmyqtuqfqr evprpjmyrd (smgkdwldjw, 19.23)
-
09 Mar 2017
Placebo
(Placebo)
mczrimzfqr(bgmraarddg) = sskwieiytk evprpjmyrd (smgkdwldjw, 17.33)
Phase 4
12
appwjtfpvx = czucpwzyfz jugftkeonv (avnebzllti, fskuhvwchs - ktprbmjtoq)
-
01 Mar 2016
Not Applicable
SCCmec | Panton Valentine leukocidin (PVL) toxin | global accessory gene regulator (ARG)
52
Molecular and Mupirocin Profiles
(Methicillin susceptible isolates)
wbviauvlzy(vxrxgcnidt) = kpsamnhumx hbauicgaqs (gdxjcxduas )
-
01 Jun 2015
Molecular and Mupirocin Profiles
(MRSA isolates)
wbviauvlzy(vxrxgcnidt) = sgqgtkzqep hbauicgaqs (gdxjcxduas )
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Regulation

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