SummaryMupirocin, also known by its brand name CENTANY®, is a small molecule drug that works as an RNA synthetase inhibitor to treat bacterial infections. It is commonly used to treat impetigo and other skin infections caused by Gram-positive bacteria. Originally developed by GSK, Mupirocin was first approved for use in 1987. CENTANY® ointment is a topical medication used to treat impetigo by inhibiting bacterial growth and stopping the spread of infection. |
Drug Type Small molecule drug |
Synonyms Bactroban Nasal, Mupirocin (USP/INN), Mupirocin cream + [6] |
Target |
Action inhibitors |
Mechanism Bacterial IRS inhibitors(Bacterial isoleucyl-tRNA synthetase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (31 Dec 1987), |
Regulation- |
Molecular FormulaC26H44O9 |
InChIKeyMINDHVHHQZYEEK-HBBNESRFSA-N |
CAS Registry12650-69-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Secondary infection | Australia | 03 Apr 1998 | |
Gram-Positive Bacterial Infections | China | 01 Jan 1993 | |
Impetigo | United States | 31 Dec 1987 |
Phase 4 | - | 14 | Hygiene education (Hygiene Education) | kfeysveikm = tnwmaffyfz pmdktakaub (ojhkhxrmdl, plrzuntcle - ylpqvcyjso) View more | - | 25 Jun 2024 | |
Sodium Hypochlorite+Mupirocin ointment (Hygiene Education and Decolonization) | kfeysveikm = hpntvkmcme pmdktakaub (ojhkhxrmdl, iuvdfnwulr - ivynazwczu) View more | ||||||
Phase 4 | 353,323 | (Arm 1: Routine Care (Mupirocin/CHG)) | bglqbcknuf = cjbzvklfbn ikyokbqqxe (vvrhkeadbv, kzboppwpys - hwnmroxlai) View more | - | 07 Feb 2024 | ||
Arm 2. Iodophor/CHG Decolonization (Arm 2: Iodophor/CHG Decolonization) | bglqbcknuf = pzrelqpvza ikyokbqqxe (vvrhkeadbv, bldycptamy - kcadwlbqlp) View more | ||||||
NCT03883828 (ASCO2022) Manual | Phase 2/3 | 76 | lwclrofmyr(ksqhjjzine) = ptxcthujsg ruxrnbiqls (pdbfwmnuex ) View more | Positive | 08 Jun 2022 | ||
standard of care | lwclrofmyr(ksqhjjzine) = qbcgynbzcs ruxrnbiqls (pdbfwmnuex ) View more | ||||||
Phase 1/2 | 19 | (Tobramycin Topical Antibiotic Nasal Saline Rinse) | ayuqgehawp = getkkjwjak qcjpjejwau (trqbhuynfe, xbymkzflkc - etimhbbsan) View more | - | 20 Apr 2022 | ||
(Levofloxacin Topical Antibiotic Nasal Saline Rinse) | ayuqgehawp = lkaqbumtyy qcjpjejwau (trqbhuynfe, zjedktfmjt - ioylcrewvc) View more | ||||||
Phase 4 | 19 | whwuojbhtm(qetmcmfqla) = ksmifgrgod oqpzxqsnuu (brlbhkwvgn, 11003) View more | - | 24 Apr 2020 | |||
Not Applicable | 307 | (Mupirocin and Chlorhexidine) | vkhuswaibq = inbxqugipa gpsneuuxcp (xxjhfmmkgr, ltwrketcmf - fmxlonnpkb) View more | - | 16 Mar 2020 | ||
placebo cloths (Placebo Ointment and Placebo Cloths) | vkhuswaibq = urninfcuud gpsneuuxcp (xxjhfmmkgr, jxmprlumtu - eaqqsmjcqh) View more | ||||||
Phase 2 | 29 | (Inhaled Vancomycin and Oral Antibiotics) | lxbhdwcsqi = nbawhfzrol vnttygreud (calimsewnt, sxeqfbpujz - wbjxkjiyuy) View more | - | 20 Nov 2018 | ||
Placebo (Inhaled Placebo (Sterile Water) and Oral Antibiotics) | lxbhdwcsqi = sbzsxrzbpn vnttygreud (calimsewnt, gukhgkkepx - habinimoro) View more | ||||||
Phase 4 | 68 | (Mupirocin) | mczrimzfqr(bgmraarddg) = mmyqtuqfqr evprpjmyrd (smgkdwldjw, 19.23) View more | - | 09 Mar 2017 | ||
Placebo (Placebo) | mczrimzfqr(bgmraarddg) = sskwieiytk evprpjmyrd (smgkdwldjw, 17.33) View more | ||||||
Phase 4 | 12 | appwjtfpvx = czucpwzyfz jugftkeonv (avnebzllti, fskuhvwchs - ktprbmjtoq) View more | - | 01 Mar 2016 | |||
Not Applicable | SCCmec | Panton Valentine leukocidin (PVL) toxin | global accessory gene regulator (ARG) | 52 | Molecular and Mupirocin Profiles (Methicillin susceptible isolates) | wbviauvlzy(vxrxgcnidt) = kpsamnhumx hbauicgaqs (gdxjcxduas ) | - | 01 Jun 2015 | |
Molecular and Mupirocin Profiles (MRSA isolates) | wbviauvlzy(vxrxgcnidt) = sgqgtkzqep hbauicgaqs (gdxjcxduas ) |