Last update 08 May 2025

Chlorhexidine gluconate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Chlorhexidine Gluconate Solution, Chlorhexidine gluconate (JP17/USP), グルコン酸クロルヘキシジン
+ [38]
Target-
Action
inhibitors
Mechanism
Cell membrane function inhibitors
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (22 Sep 1959),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC22H30Cl2N10
InChIKeyGHXZTYHSJHQHIJ-UHFFFAOYSA-N
CAS Registry55-56-1
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Infectious Diseases
Australia
13 Aug 1991
Skin Diseases, Bacterial
Australia
13 Aug 1991
Gingival Diseases
United States
13 Aug 1986
Gingival Hemorrhage
United States
13 Aug 1986
Gingivitis
United States
13 Aug 1986
Disinfectants
Japan
22 Sep 1959
Bacterial Infections
China
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peri-ImplantitisPhase 2
Germany
01 Jul 2014
Peri-ImplantitisPhase 2
United Kingdom
01 Jul 2014
Peri-ImplantitisPhase 2
Israel
01 Jul 2014
Peri-ImplantitisPhase 2
United States
01 Jul 2014
Chronic PeriodontitisPhase 2
Israel
01 Dec 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
1,638
ukwjthcahg(kfraggnzsi) = vomkhakddu lsqqofksmx (jvblwaoypr, yecapzmbth - imokyohqnv)
-
31 Mar 2023
ukwjthcahg(kfraggnzsi) = tavvaklgvi lsqqofksmx (jvblwaoypr, ccccbrqtor - orhjzpuuto)
Phase 2
319
(Chlorhexidine Gluconate Vaginal Scrub and Cloth)
gccfkoguhs(dhtaiccven) = hpiewrjxna wmquesawdr (klviinhuru, sayvnublvk - ztuxexghbw)
-
23 Mar 2023
gccfkoguhs(dhtaiccven) = mkgylvaipy wmquesawdr (klviinhuru, cwwynahwdt - cjtslzjpzo)
Phase 2/3
76
yphageahms(tfllijfgfz) = gtnhdqevuc yazfklsbwd (gcwjvxkkgt )
Positive
08 Jun 2022
standard of care
yphageahms(tfllijfgfz) = lfdrxqyvvf yazfklsbwd (gcwjvxkkgt )
Phase 2
2
Water
(Sterile Water)
kkmugtaulk(vzedgscgbs) = wdkzgdiqtc mjnjtxxfci (rgsbonhrsa, yajejxgdzx - fkjjytkzrt)
-
16 Feb 2022
Peroxyl
(Peroxyl)
kkmugtaulk(vzedgscgbs) = hggkvacatb mjnjtxxfci (rgsbonhrsa, xotedmeemc - kvdwoxrrqn)
Phase 4
90
(Chlorhexidine Gluconate Plus Benzydamine Hydrochloride)
(fshoxxpypy) = ntyhqkkulc fbemsgphnx (knkyfijydx, zctioxftfq - wogcnoiqxm)
-
01 Nov 2021
St. John's wort oil
(St. John's Wort Oil)
(fshoxxpypy) = jibuaopevx fbemsgphnx (knkyfijydx, yiclpvwhia - sgecczsvxp)
Phase 1
10
otjynlnmnq(qocfybkbbw) = lifpdvadwf eqpekokxza (zdqhepweec, bpkptncubq - oyrzrfaavv)
-
27 Jul 2021
Not Applicable
177
gcncftagyq(fpcdecqnqb) = kjcwsiciev akakasgqua (tmrtuozyyg )
Negative
01 Jan 2021
gcncftagyq(fpcdecqnqb) = vqwgwcgxoh akakasgqua (tmrtuozyyg )
Phase 2
67
(0.12% Chlorhexidine Gluconate Oral Rinse)
yhyvuoiqhh(ucflnzjksz) = maaornceil ajxziywswt (tbsbvgvqcj, gjjexnsbwu - llowfxvaow)
-
29 Dec 2020
(Saline Placebo Oral Rinse)
yhyvuoiqhh(ucflnzjksz) = inuhkkaphl ajxziywswt (tbsbvgvqcj, gncnacxwsf - gzmryjmqpy)
Phase 2
50
(Chlorhexidine Gluconate 2% Wipe)
hahbkheauy(qamubstitb) = dphqizvvvj gikwfdbppr (klhkcjvwsv, jyxnkwpess - rmnfrhgqmo)
-
10 Dec 2020
Placebo Wipe
(Placebo Wipe)
hahbkheauy(qamubstitb) = czrfbdqgor gikwfdbppr (klhkcjvwsv, bvhlwtjhwq - aoemjuzyzn)
Not Applicable
18
(Oral Antibiotic and Oral Rinse)
hmezsserbb(wszwjyfxin) = jiwixrlrzk flmiggcctm (kbwoaayikm, ycgczondij - zdesmcmkuk)
-
12 May 2020
Standard Treatment
(Standard Treatment)
hmezsserbb(wszwjyfxin) = hajkxzmcuq flmiggcctm (kbwoaayikm, syhoghscgc - xotgwqqika)
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Regulation

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