The focus of this study is on two types of mouthwashes - one containing a chlorhexidine (CHX) at 0.2% (CHX), and the other one containing CHX at a lower concentration of 0.12% with cetylpyridinium chloride (CPC). Both mouthwashes are used to help in the treatment of gum disease. CHX has been known for a long time for its effectiveness against plaque and mouth inflammation. It could inhibit and even kill them. However higher concentrations of CHX comes with unwanted side effect including altered taste, teeth staining and irritation in the mouth. Interestingly, these side effects seem to occur less frequently when a lower concentration CHX solution is used. CPC also combats bacteria by adhering quickly to the surfaces inside your mouth, although it has less substantivity than CHX, it has been shown to reduce plaque and gum inflammation effectively, and it typically causes fewer side effects than CHX. We hypothesize that this new formulation of CHX 0.12%+CPC mouthwash is non-inferior to CHX 0.2% in terms of its anti-plaque and anti-inflammatory properties while presenting with less side effects after 21 days of use. Microbiological samples and fluids from periodontal pockets will be collected before and after treatment for analysis of microbiological effects.

Start Date01 Jul 2025

Sponsor / Collaborator

The University of Hong Kong

[+1]

CTRI/2025/04/085327

/ Not yet recruitingPhase 4IIT

One-year Comparative evaluation of effect of emblica officinalis, Epigallactocatechin-3-gallate, chlorhexidine using selective etch technique on clinical performance of composite resin restoration in cases of Non carious cervical lesions: A randomized clinical study - NIL

Start Date15 May 2025

Sponsor / Collaborator-

CTRI/2025/04/085249

/ Not yet recruitingPhase 3IIT

Efficacy of Sodium Hypochlorite, Chitosan and Chlorhexidine Gluconate as non-activated and Endo-Activator activated irrigants on Microbial Load, Obturation Quality and Post-Endodontic Pain In Primary Teeth- A Randomized Comparative Clinical Study - NIL

Start Date06 May 2025

Sponsor / Collaborator-

100 Clinical Results associated with Chlorhexidine gluconate

100 Translational Medicine associated with Chlorhexidine gluconate

100 Patents (Medical) associated with Chlorhexidine gluconate

8,556

Literatures (Medical) associated with Chlorhexidine gluconate

01 Dec 2025·MOLECULAR BIOLOGY REPORTS

Evaluation of the effects of Andiz extract on the experimentally wound in rats by microbiological and gene expression methods

Article

Author: Kavut, Büşra Sümeyye ; Önalan, Şükrü ; Talmaç, Ahmet Cemil

OBJECTIVES:

This study aimed to investigate the effects of andiz extract on wound healing and compare it with saline and chlorhexidine gluconate. Microbial DNA load was used to evaluate its antibacterial effects, and gene expression methods were used to assess its contribution to cytokine release and wound healing.

METHODS AND RESULTS:

A standardized wound site was created with a 3 mm diameter punch on 32 male Wistar albino rats. The rats were divided into four groups: Control (n = 5), Saline (n = 9), Chlorhexidine gluconate (n = 9), and Andiz extract (n = 9). Five rats in the control group were euthanised without any treatment. Irrigations of the Saline, Chlorhexidine, and Extract groups were provided regularly. After the tissue samples were taken in the 1st week, 2nd week, and 3rd week, three rats were euthanized each week for each group. The total bacterial DNA load on the samples taken was determined by a nano spectrophotometer. β-actin was chosen as housekeeping, and target gene primers were created for TGF-β and IL-1β. Expression amounts of target genes were measured by Real-Time PCR with the application of the created primers. There is a significant difference between the Extract group and the other groups regarding total bacterial DNA load. The whole bacterial load was 185% less than the initial values. TGF-β and IL-1β genes evaluated regarding gene expression were measured at the highest value in the Extract group.

CONCLUSIONS:

This study showed the antibacterial effects of the Extract and its positive contributions to wound healing.

01 Sep 2025·COLLOIDS AND SURFACES B-BIOINTERFACES

Impact of different chemical debridement agents on early cellular responses to titanium dental implants: A transcriptome-based in vitro study on peri-implant tissue regeneration

Article

Author: Linke, Dirk ; Wang, Qiang ; Sigurjónsson, Ólafur Eysteinn ; Haugen, Håvard Jostein ; Ma, Qianli ; Lyngstadaas, Ståle Petter

BACKGROUND:

Poor peri-implant health leads to biofilm accumulation, peri-implantitis, and bone loss. Chemical debridement may help maintain peri-implant health, but its effects on peri-implant cells remain unclear.

METHODS:

Five cleaning agents-hydrogen peroxide (H2O2), Poloxamer, H2O2 +Poloxamer, Perisolv, and Paroex-were applied on titanium (Ti) surfaces. Mouse pre-osteoblasts (MC3T3-E1), human gingival fibroblasts (HGF), and human bone marrow stromal cells (hBMSC) were cultured on agent-treated Ti surfaces for up to 120 minutes to assess morphology, cytotoxicity, adhesion, and proliferation. RNA sequencing was performed on hBMSC.

RESULTS:

Except for Poloxamer, all treatments inhibited cellular spreading. Paroex increased cytotoxicity and inhibited proliferation. Perisolv impaired hBMSC adhesion and variably affected proliferation. H2O2, alone or with Poloxamer, elevated cytotoxicity and inhibited adhesion in hBMSCs but not MC3T3-E1 or HGF. In contrast, Poloxamer-treated Ti surfaces enhanced adhesion and proliferation across all cell types. RNA sequencing revealed that oxidant-based treatments (H2O2, H2O2 +Poloxamer, Perisolv) suppressed key genes for proliferation (HMGA2, JAG1, NOTCH1, YAP1, TBX3), anti-apoptosis (MCL1, BCL2L2), and adhesion (ITGA2, ITGB3, SPP1), while inhibiting MAPK, PI3K-Akt, and pluripotency pathways.

CONCLUSION:

Commercial agents like Perisolv and Paroex impair hBMSC function, with Paroex demonstrating significant cytotoxicity. H2O2 exhibits toxicity, particularly to hBMSCs. Poloxamer improves cell attachment and growth. Given these findings, careful selection of debridement agents is critical to balance cleaning efficacy and cytocompatibility. The adverse effects on hBMSCs necessitate prompt removal postapplication. Further research on biomaterials supporting tissue regeneration postdebridement is needed to restore peri-implant health.

01 Jul 2025·Journal of clinical orthopaedics and trauma

What is the most advantageous lavage solution to use for fungal prosthetic joint infections

Article

Author: Doub, James B ; Manchester, Maggie

Background:

Fungal prosthetic joint infections (PJI) are increasing yet we have a poor understanding on the proper treatment of these complex infections especially with respect to most advantageous lavage solutions to use clinically. Consequently, the objective of this study was to determine which commonly used lavage solutions are most advantageous at dispersing fungal biofilms.

Methods:

Nine clinical isolates from past fungal prosthetic joint infections were used to form biofilms in 24 microwell plates. Then different lavage solutions were instilled, and residual biofilm were measured and compared to normal saline lavage solutions. Moreover, fungal biofilms were directly observed with scanning electron microscopy.

Results:

All lavage solutions evaluated significantly (p < 0.05) reduced fungal biofilms compared to normal saline. However, chlorhexidine gluconate and sodium hypochlorite were able to disperse fungal biofilms significantly (p˂0.05) more than the other lavage solutions. As well, scanning electron microscopy showed fungal biofilms are typically composed of hyphae and yeast forms for most Candidal species.

Conclusion:

All lavage solutions can reduce Candidal biofilms, but chlorhexidine gluconate and sodium hypochlorite were the most advantageous agents in disrupting Candidal biofilms. Yet given the potential tissue toxicity associated with sodium hypochlorite should prioritize the use of chlorohexidine as lavage solutions in the clinical treatment of fungal PJI to help degrade biofilms on retained hardware and tissues. However, further studies are needed to determine the mechanism associated with degradation of fungal biofilms as well as evaluating novel ways to prevent Candidal hyphae formation in PJI.

News (Medical) associated with Chlorhexidine gluconate

29 Apr 2025

·www.businesswire.com

Expanded Real-World Data Presented at INS 2025 Reinforces Better Outcomes with Access Vascular’s Hydrophilic Midline Catheter

BILLERICA, Mass.--(BUSINESS WIRE)--Access Vascular, Inc. (AVI), a leader in advanced vascular access technology, today announced the presentation of new, expanded real-world data at the 2025 Infusion Nurses Society (INS) Annual Meeting in Las Vegas. The data reinforces significant improvements in midline catheter outcomes associated with AVI’s proprietary hydrophilic biomaterial (HBM), building on findings previously shared at the Association for Vascular Access Annual Meeting in 2024. The study was independently designed and conducted by an acute care hospital in Montana and evaluated outcomes across 288 patients. It compared a conventional chlorhexidine gluconate (CHG)-coated polyurethane catheter to Access Vascular’s HydroMID® HBM-based catheter. Key findings announced at INS 2025: 75% Lower Complication Rate: HydroMID® exhibited a 5.3% complication rate, compared with 21.8% for CHG polyurethane. Greater Therapy Completion: 95% of HydroMID® patients completed therapy with the original line in place, compared to just 80% for CHG polyurethane. Extended Dwell Time: HydroMID® remained in place nearly 40% longer than CHG polyurethane catheters. “With more than 125 catheters in each study arm, these findings add to the growing body of evidence that our hydrophilic biomaterial platform delivers tangible benefits where it matters most: improved outcomes for patients,” said Jim Biggins, CEO of Access Vascular. “Fewer complications, longer dwell times, and higher rates of therapy completion all support a safer, more efficient experience for patients and providers alike.” Unlike traditional polyurethane catheters, AVI’s devices are constructed from MIMIX®, a proprietary hydrogel-based material designed to reduce thrombus formation and bacterial adhesion. This fundamental material change targets the root causes of vascular access device failure. “Concerns relating to frequent complications with our previous midline device kept growing. We felt defeated in our efforts to get our patients to the end of their therapy – we knew we could do better for them,” said Kelsey Pearson, RN, VA-BC at Benefis Hospital. “We have noticed a significant improvement in our outcomes and provided a better patient experience since switching to the HydroMID® catheter.” About Access Vascular Access Vascular, Inc. (AVI) is redefining vascular access by engineering devices from a fundamentally better material. The MIMIX® hydrogel platform is designed to reduce the complications associated with traditional catheters, helping clinicians keep lines in place, improving the patient experience and delivering value to hospitals. For more information, please visit www.accessvascularinc.com, and follow us on LinkedIn.

Clinical ResultAHA

29 Aug 2024

·www.prnewswire.com

Irrimax Launches New IRRISEPT® Kits-Continues to Provide Irrigation Innovation

Completes Phase II of Promised Innovation Pipeline LAWRENCEVILLE, Ga., Aug. 21, 2024 /PRNewswire/ -- Medical device manufacturer Irrimax Corporation, known globally for its antimicrobial wound lavage product, IRRISEPT®, delivers promised innovation and enhancements in multiple healthcare market segments. Irrimax is now introducing new products and accessories to enable the use of the proprietary Irrisept solution with powered irrigation devices, continuing to expand on the company's mission to reduce infections and healthcare costs and improve patient outcomes. Continue Reading Irrisept Wound Solution Kit Irrisept Accessory Kit "Irrimax is committed to meeting the needs of its customers, which is at the core of our customer-centric approach," shares President and Chief Operating Officer Michael Gil. "While Irrisept has become a standard of care in many hospitals globally, our customers have expressed additional needs regarding how and when they could use Irrisept, especially in minimally invasive procedures. We developed these products in response to those customer needs and insights, and we're thrilled to be able to answer that market demand with these new product innovations." Irrimax announced that it would expand its portfolio by releasing a series of enhancements and new products, instituting a two-phase innovation pipeline, and releasing five new products within a two-year window. Phase one took the flagship IRRISEPT Antimicrobial Wound Lavage product design and considered features and applications for utilization across the continuum of care in settings ranging from pre-hospital to acute and post-acute. Now Irrimax has launched the second phase, unveiling two new kits, the 'IRRISEPT Accessory Kit' and 'IRRISEPT Wound Solution Kit.' These new kits are designed to be used in conjunction with the original IRRISEPT Antimicrobial Wound Lavage product. This gives clinicians flexibility and choice in their application of IRRISEPT by choosing to use manual compression for irrigation or by attaching an adapter and spiking the bottle for utilization with powered irrigation systems such as suction irrigation, pulse lavage, negative pressure wound therapy, and other systems. Both kits are now available in the US market. Irrimax is actively working to make its added portfolio options available globally and continues to execute additional projects in its innovative product and development pipeline. About Irrimax Corporation Established in 1994, Irrimax Corporation has been steadfast in its mission to reduce infections and healthcare costs while improving patient outcomes. Its flagship product is IRRISEPT Antimicrobial Wound Lavage, containing 0.05% Chlorhexidine Gluconate (CHG) in 99.95% Sterile Water for Irrigation, USP. For more information, visit . SOURCE Irrimax Corporation

Phase 2

23 Aug 2024

·pharma.economictimes.indiatimes.com

Govt bans 156 medicines including antibiotics, painkillers, multivitamins: Here is the full list

New Delhi: In a significant move aimed at safeguarding public health, the Indian government has banned 156 fixed-dose combination (FDC) drugs, including a variety of antibiotics, painkillers, multivitamins, and medications for treating fever and hypertension. This decision marks the largest crackdown on FDCs since 2016, when 344 such drugs were prohibited. The Union Ministry of Health and Family Welfare issued a gazette notification on Thursday, officially prohibiting the manufacture, sale, and distribution of the banned FDCs. The ban was based on the recommendations of an expert panel that reviewed a total of 324 FDCs. Impact on Pharmaceutical Industry The banned FDCs include popular combinations such as mefenamic acid and paracetamol injections, commonly used for pain relief and fever, and omeprazole magnesium with dicyclomine HCl, used to treat abdominal pain. The ban is expected to impact major pharmaceutical companies, including Sun Pharmaceuticals, Cipla, Dr. Reddy's Laboratories, Torrent Pharmaceuticals, and Alkem Laboratories. Fixed Dose Combinations Drug Banned List Here is a table listing all 156 banned Fixed Dose Combinations (FDCs) SN Fixed Dose Combination (FDC) 1 Amylase + Protease + Glucoamylase + Pectinase + Alpha Galactosidase + Lactase + Beta-Gluconase + Cellulase + Lipase + Bromelain + Xylanase + Hemicellulase + Malt diastase + Invertase + Papain 2 Antimony Potassium Tartrate + Dried Ferrous Sulphate 3 Benfotiamine + Silymarin + L-Ornithine L-aspartate + Sodium Selenite + Folic acid + Pyridoxine hydrochloride 4 Bismuth Ammonium Citrate + Papain 5 Cyproheptadine HCl + Thiamine HCl + Riboflavine + Pyridoxine HCl + Niacinamide 6 Cyproheptadine Hydrochloride + Tricholine Citrate + Thiamine Hydrochloride + Riboflavine + Pyridoxine Hydrochloride 7 Rabeprazole Sodium (As enteric coated tablet) + Clidinium Bromide + Dicyclomine HCl + Chlordiazepoxide 8 Fungal Diastase + Papain + Nux vomica Tincture + Cardamom Tincture + Casein Hydrolysed + Alcohol 9 Mefenamic Acid + Paracetamol Injection 10 Omeprazole Magnesium + Dicyclomine HCl 11 S-adenosyl methionine + Metadoxine + Ursodeoxycholicacid BP + L-Methylfolate Calcium eq. to L- Methylfolate + Choline bitartratee + Silymarin + L-ornithine Laspartate + Inositol + Taurine 12 Silymarin + Thiamine Mononitrate + Riboflavin + Pyridoxine HCl + Niacinamide + Calcium pantothenate + Vitamin B12 13 Silymarin + Pyridoxine HCl + Cyanocobalamin + Niacinamide + Folic Acid 14 Silymarin + Vitamin B6 + Vitamin B12 + Niacinamide + Folic acid + Tricholine Citrate 15 Sodium Citrate + Citric Acid Monohydrate Flavored with Cardamom Oil, Caraway Oil, Cinnamon Oil, Clove Oil, Ginger Oil + Alcohol 16 Sucralfate + Acelofenac 17 Sucralfate + Domperidone + Dimethicone 18 Sucralfate + Domperidone 19 Tincture Ipecacuanha + Tincture Urgenia + Camphorated Opium Tincture + Aromatic Spirit of Ammonia + Chloroform + Alcohol 20 Ursodeoxycholic Acid + Metformin HCl 21 Weak Ginger tincture + Aromatic Spirit of Ammonia + Peppermint Spirit + Chloroform + Sodium Bicarbonate + Compound Cardamom + Alcohol 22 Sucralfate + Pantoprazole Sodium + Zinc Gluconate + Light Magnesium Carbonate 23 Aloe + Vitamin E Soap 24 Povidone Iodine+ Metronidazole + Aloe 25 Azelaic acid + Tea Tree Oil + Salicylic acid + Allantoin + Zinc oxide + Aloe vera + Jojoba oil + Vitamin E + Soap noodles 26 Azithromycin + Adapalene 27 Calamine + Aloes + Allantoin 28 Calamine + Diphenhydramine Hydrochloride + Aloe + Glycerine + Camphor 29 Chlorphenesin + Zinc oxide + Starch 30 Clindamycin Phosphate + Zinc acetate 31 Gamma Benzene Hexachloride + Benzocaine 32 Glucosamine hydrochloride + Diacerein + Menthol + Camphor + Capsaicin 33 Hydroxyquinone 2.0%w/w + Octyl Methoxycinnamate 5.0% w/w + Oxybenzone 30 % w/w 34 Ketoconazole +Zinc Pyrithione +D-Panthenol +Tea Tree Oil +Aloes 35 Ketoconazole +Aloe vera+ Vitamin A Acetate 36 Ketoconazole +Aloes + ZPTO 37 Kojic Acid +Arbutin +Octinoxate +Vitamin E + Mulberry 38 Lornoxicam +capsaicin +menthol+ camphor 39 Lornoxicam + Thiocolchicoside +Oleum Lini +Menthol + Methyl salicylate 40 Menthol + Aloe vera Topical Spray 41 Menthol +Lignocaine HCl +Aloe vera gel +Clotrimazole +Diphenhydramine 42 Miconazole nitrate + Gentamicin + Fluocinolone Acetonide +Zinc Sulphate 43 Miconazole +Tinidazole 44 Minoxidil +Aminexil+ Alcohol 45 Minoxidil +Azelaic acid + saw palmetto 46 Minoxidil +Aminexil 47 Pine Bark extract+ Kojic acid +Sodium Ascorbyl Phosphate 48 Povidone Iodine +Tinidazole +Zinc sulphate 49 Povidone Iodine + Ornidazole + Dexpanthenol 50 Salicyclic acid +Aloe vera+ Allantoin +D-Panthenol 51 Silver sulphadiazine +Chlorhexidine Gluconate solution +Allantoin + Aloe vera gel +Vitamin E acetate 52 Sodium salicylate + Zinc gluconate + Pyridoxine HCl 53 Tetracycline + Colistin Sulphate 54 Clomiphene +Ubidecarenone 55 Combikit of Clomiphene Citrate + Estradiol Valerate 56 Flavoxate HCl +Ofloxacin 57 Clomiphene Citrate +N-Acetylcysteine 58 Primerose Oil +Cod liver oil 59 Sildenafil Citrate +Papaverine +L-Arginine 60 Tranexamic acid +Mefenamic acid + Vitamin K1 61 Divalproex Sodium +Oxcarbazepine 62 Divalproex Sodium + Levetiracitam 63 Ergotamine tartrate +Caffeine + Paracetamol +Prochlorperazine maleate 64 Piracetam + Ginkgo biloba extracts + Vinpocetin 65 Ginkgo biloba + methylcobalamin 66 Ginkgo biloba + methylcobalamin + Alpha lipoic acid +Pyridoxine HCl 67 Ginseng Extract +Dried extract of Ginkgo Biloba 68 Meclizine HCl+ Paracetamol + Caffeine 69 Nicergoline + Vinpocetine 70 Gamma Linolenic Acid + Methylcobalamin 71 Beclomethasone Dipropionate + Neomycin Sulphate + Clotrimazole + Lignocaine HCl 72 Boric acid+ Phenylephrine HCl + Naphazoline Nitrate + Menthol + Camphor 73 Naphazoline HCl + Chlorpheniramine Maleate + Zinc Sulphate + Hydroxy Propyl Methyl Cellulose 74 Chlorpheniramine Maleate + Naphazoline HCl + Zinc Sulphate + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 75 Chlorpheniramine Maleate + Naphazoline HCl + Hydroxy Propyl Methyl Cellulose 76 Chlorpheniramine Maleate + Sodium Chloride + Boric Acid + Tetrahydrozoline HCl 77 Chlorpheniramine Maleate + Phenylephrine HCl + Antipyrine 78 Ketorolac Tromethamine + Chlorpheniramine Maleate + Phenylephrine HCl + Hydroxy Propyl Methyl Cellulose 79 Ketorolac Tromethamine + Flurometholone 80 Naphazoline HCl + Zinc Sulphate + Boric Acid + Sodium Chloride+ Chlorpheniramine Maleate 81 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Boric Acid + Borax + Menthol + Camphor 82 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Chlorpheniramine Maleate SN Fixed Dose Combination (FDC) 83 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Menthol + Camphor 84 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 85 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Methylparaben 86 Methenamine + Sodium Benzoate + Benzyl Alcohol 87 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 88 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate + Caffeine 89 Propoxyphene + Chlorpheniramine Maleate 90 Propoxyphene + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 91 Propoxyphene + Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride 92 Sodium Benzoate + Sodium Citrate + Citric Acid 93 Vitamin A Palmitate + Vitamin C + Vitamin E + Vitamin B6 + Vitamin B12 94 Vitamin A Palmitate + Vitamin C + Vitamin E + Niacinamide 95 Vitamin B6 + Vitamin B12 + Vitamin C 96 Vitamin B6 + Vitamin B12 + Niacinamide 97 Vitamin B12 + Vitamin B6 + Vitamin C + Folic Acid 98 Vitamin B12 + Vitamin B6 + Niacinamide + Folic Acid 99 Vitamin C + Vitamin E + Vitamin A + Niacinamide 100 Vitamin D + Calcium + Magnesium 101 Vitamin D + Calcium + Magnesium + Zinc 102 Calcium + Vitamin D + Vitamin K 103 Calcium + Vitamin D + Magnesium + Zinc 104 Calcium + Vitamin D + Vitamin K + Magnesium 105 Calcium + Vitamin D + Vitamin K + Magnesium + Zinc 106 Vitamin E + Vitamin A + Vitamin C + Niacinamide 107 Vitamin E + Vitamin A + Vitamin C + Folic Acid 108 Vitamin E + Vitamin A + Vitamin C + Biotin 109 Vitamin E + Vitamin A + Vitamin C + Vitamin B12 110 Vitamin E + Vitamin C + Folic Acid 111 Vitamin E + Vitamin C + Biotin 112 Vitamin E + Vitamin C + Vitamin B12 113 Vitamin E + Vitamin C + Zinc 114 Calcium + Vitamin D + Omega-3 Fatty Acids 115 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K 116 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Magnesium 117 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Zinc 118 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene 119 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene + Zinc 120 Vitamin C + Vitamin E + Beta-Carotene 121 Vitamin C + Vitamin E + Beta-Carotene + Zinc 122 Vitamin C + Vitamin E + Selenium 123 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids 124 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Magnesium 125 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Zinc 126 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Biotin 127 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 128 Vitamin E + Vitamin A + Vitamin C + Zinc 129 Vitamin E + Vitamin A + Vitamin C + Selenium 130 Vitamin E + Vitamin A + Vitamin C + Biotin 131 Vitamin E + Vitamin A + Vitamin C + Folic Acid + Niacinamide 132 Vitamin E + Vitamin C + Beta-Carotene + Zinc 133 Vitamin C + Vitamin E + Biotin + Folic Acid 134 Vitamin C + Vitamin E + Beta-Carotene + Folic Acid 135 Vitamin C + Vitamin E + Beta-Carotene + Selenium 136 Vitamin E + Vitamin C + Beta-Carotene + Biotin 137 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Biotin 138 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 139 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B12 140 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B6 141 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Folate 142 Calcium + Vitamin D + Magnesium + Vitamin K + Omega-3 Fatty Acids 143 Calcium + Vitamin D + Magnesium + Vitamin K + Biotin 144 Calcium + Vitamin D + Magnesium + Vitamin K + Selenium 145 Calcium + Vitamin D + Magnesium + Vitamin K + Vitamin B12 146 Calcium + Vitamin D + Magnesium + Vitamin K + Folate 147 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B6 148 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B12 149 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Folic Acid 150 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Biotin 151 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Selenium 152 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids 153 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Zinc 154 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Biotin 155 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Selenium 156 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Vitamin B12

Drug Approval

100 Deals associated with Chlorhexidine gluconate

External Link

KEGG	Wiki	ATC	Drug Bank
D00858	Chlorhexidine gluconate	A01AB03 S03AA04 S02AA09	DB00878

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Periodontitis	United States	Dexcel Pharma Technologies Ltd.	15 May 1998
Infectious Diseases	Australia	Bridgewest Perth Pharma Pty Ltd.	13 Aug 1991
Skin Diseases, Bacterial	Australia	Bridgewest Perth Pharma Pty Ltd.	13 Aug 1991
Gingival Diseases	United States	3M Co.	13 Aug 1986
Gingival Hemorrhage	United States	3M Co.	13 Aug 1986
Gingivitis	United States	3M Co.	13 Aug 1986
Bacterial Infections	United States	Mölnlycke Health Care AB	17 Sep 1976
Disinfectants	Japan	Sumitomo Pharma Co., Ltd.	22 Sep 1959

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Peri-Implantitis	Phase 3	United States	Dexcel Pharma Technologies Ltd.	01 Jul 2014
Peri-Implantitis	Phase 3	Germany	Dexcel Pharma Technologies Ltd.	01 Jul 2014
Peri-Implantitis	Phase 3	Israel	Dexcel Pharma Technologies Ltd.	01 Jul 2014
Peri-Implantitis	Phase 3	United Kingdom	Dexcel Pharma Technologies Ltd.	01 Jul 2014
Chronic Periodontitis	Phase 3	Israel	Dexcel Pharma Technologies Ltd.	01 Dec 2010
Pneumonia, Ventilator-Associated	Clinical	United States	-	01 Jul 2010

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03326726 (CTgov)	Phase 2	-	30	chlorhexidine gluconate	johcoxtjwk(zjdgepwrgs) = mpwnvnokem pkirdixzum (nftxqovzlt, 0.0013) View more	-	28 Sep 2023
NCT03385304 (Aqueous-PREP, CTgov)	Phase 4	Surgical Wound Infection \| Fractures, Open	1,638	10% povidone-iodine (1% free iodine) in purified water+4% chlorhexidine gluconate (CHG) in purified water (10% Povidone-iodine (1% Free Iodine) in Purified Water)	zigeintmqn = zfqfyfecyd zxbktqawqf (racmstpwgj, avcwmynaed - bgqpacaybb) View more	-	31 Mar 2023
				10% povidone-iodine (1% free iodine) in purified water+4% chlorhexidine gluconate (CHG) in purified water (4% Chlorhexidine Gluconate (CHG) in Purified Water)	zigeintmqn = xzkkifsluq zxbktqawqf (racmstpwgj, ftylfybkel - uyxkvrhjpw) View more
NCT03423147 (PRACTICAL, CTgov)	Phase 2	Surgical Wound Infection \| Cross Infection	319	4% Chlorhexidine gluconate vaginal scrub (Chlorhexidine Gluconate Vaginal Scrub and Cloth)	udroosvjho = phrulglaso aimsilxnup (ehrdykgdjz, cmtjuwvnpt - sishvrwuiw) View more	-	23 Mar 2023
				2% chlorhexidine gluconate cloth (Standard Treatment)	udroosvjho = hpnogcmava aimsilxnup (ehrdykgdjz, gvruvuzzfv - wufuhdcfgj) View more
NCT03883828 (ASCO2022) Manual	Phase 2/3	Radiodermatitis	76	mupirocin+Chlorhexidine gluconate	cdpgailwwq(clxgpjosbg) = qityujjqlf nkihhnanzu (zhrbmvsown ) View more	Positive	08 Jun 2022
				standard of care	cdpgailwwq(clxgpjosbg) = jpkoexzypj nkihhnanzu (zhrbmvsown ) View more
NCT04748783 (COL, CTgov)	Phase 2	COVID-19	2	Water (Sterile Water)	lrvvxetriz(smyuerkekw) = ocuwcxkfaf dmafnwivdw (iuldgoltid, xgmzoztimc - qwziafhciw) View more	-	16 Feb 2022
				Peroxyl (Peroxyl)	lrvvxetriz(smyuerkekw) = kmbptnvcce dmafnwivdw (iuldgoltid, gonqgtwjgw - tqpwbhjtvr) View more
NCT02395614 (CTgov)	Not Applicable	Surgical Wound Infection \| Breast Cancer	88	Chlorhexidine irrigation (Chlorhexidine Irrigation)	wkkbgssgug(cdgvltxkrk) = smvvfvzdwi jvgiripxpt (llveyodcoo, jmdzytgrzs - ezmrqntggw) View more	-	26 Jan 2022
				cefazolin+bacitracin+gentamicin (Triple Antibiotic Irrigation)	wkkbgssgug(cdgvltxkrk) = qsjkwrcezt jvgiripxpt (llveyodcoo, bltumljozr - tbtrbzjspw) View more
NCT04373421 (CTgov)	Phase 4	Postoperative Complications	90	Chlorhexidine Gluconate+benzydamine hydrochloride (Chlorhexidine Gluconate Plus Benzydamine Hydrochloride)	cfnubcipsq(sgrjylutja) = rhrgbgjlyk bavybtiiky (mpdhgqvrss, 21.9) View more	-	01 Nov 2021
				St. John's wort oil (St. John's Wort Oil)	cfnubcipsq(sgrjylutja) = zqucfobzsj bavybtiiky (mpdhgqvrss, 24.1) View more
NCT02326467 (CTgov)	Phase 1	Hypersensitivity \| Exanthema \| Infectious Diseases	10	Chlorhexidine gluconate	jznnpbipjw = htswadugth comykkvsbu (cznsnktczl, wovcmwwiea - qyyzfppbhz) View more	-	27 Jul 2021
Pubmed \| Cancer	Not Applicable	Neoplasms \| Hematopoietic stem cell transplantation	177	Chlorhexidine gluconate	uleijxumem(lpfhikfegy) = gsdcseomwu gycgccgdiu (omsmjrkazb )	Negative	01 Jan 2021
				Chlorhexidine gluconate	uleijxumem(lpfhikfegy) = vzaveluvzq gycgccgdiu (omsmjrkazb )
NCT02589067 (CTgov)	Phase 2	Staphylococcal Infections	67	Chlorhexidine Gluconate (0.12% Chlorhexidine Gluconate Oral Rinse)	qhzllqspsu = uewptqczej bbknuydscj (scmlctkujd, kvsimpmoet - wowhrqwksp) View more	-	29 Dec 2020
				placebo+Chlorhexidine Gluconate (Saline Placebo Oral Rinse)	qhzllqspsu = wcnjlnfibl bbknuydscj (scmlctkujd, yopgeqgsuk - paqzpfdxmn) View more

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Chlorhexidine gluconate

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