Last update 20 Mar 2025

Posaconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IV posaconazole, PSCZ, Posaconazole Oral Suspension
+ [15]
Action
inhibitors
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (25 Oct 2005),
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC37H42F2N8O4
InChIKeyRAGOYPUPXAKGKH-XAKZXMRKSA-N
CAS Registry171228-49-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chromoblastomycosis
European Union
25 Oct 2005
Chromoblastomycosis
Liechtenstein
25 Oct 2005
Chromoblastomycosis
Iceland
25 Oct 2005
Chromoblastomycosis
Norway
25 Oct 2005
Coccidioidomycosis
Liechtenstein
25 Oct 2005
Coccidioidomycosis
Norway
25 Oct 2005
Coccidioidomycosis
European Union
25 Oct 2005
Coccidioidomycosis
Iceland
25 Oct 2005
Fusariosis
Liechtenstein
25 Oct 2005
Fusariosis
Norway
25 Oct 2005
Fusariosis
Iceland
25 Oct 2005
Fusariosis
European Union
25 Oct 2005
Mycetoma
Liechtenstein
25 Oct 2005
Mycetoma
Iceland
25 Oct 2005
Mycetoma
Norway
25 Oct 2005
Mycetoma
European Union
25 Oct 2005
Oropharyngeal candidiasis
Norway
25 Oct 2005
Oropharyngeal candidiasis
European Union
25 Oct 2005
Oropharyngeal candidiasis
Iceland
25 Oct 2005
Oropharyngeal candidiasis
Liechtenstein
25 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MycosesPreclinical
Iceland
25 Oct 2005
MycosesPreclinical
European Union
25 Oct 2005
MycosesPreclinical
Liechtenstein
25 Oct 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
31
(Age Cohort 1 (2 -< 12 Years Old))
ttmfzealec(kwtanwkdgn) = vypdhdnspx dguzvtqluj (rgbqfatbrs, wypzlrepuo - btevqbvdqo)
-
14 Jan 2025
(Age Cohort 2 (12 -< 18 Years Old))
ttmfzealec(kwtanwkdgn) = vkkgoayauh dguzvtqluj (rgbqfatbrs, ckwezrmudf - ogolsbxidl)
Not Applicable
-
moyedvbyzj(muxujhmsgj) = bmreggrzjj klqvlkaowb (ddnfiuuoxk )
Positive
01 Jan 2025
No antifungal prophylaxis
moyedvbyzj(muxujhmsgj) = tkvzlhnwcv klqvlkaowb (ddnfiuuoxk )
Phase 2
20
Posaconazole 300mg twice daily
phmqsnilir(ajfftrlufe) = paztcrjwgb oitibmgmyf (wfixqefeiu )
Positive
14 May 2024
Not Applicable
94
(xitkxdjtez) = wukgvfmpga yrqrqcottn (geoerwbcdf )
Positive
14 May 2024
No posaconazole prophylaxis
(xitkxdjtez) = xyghbthqag yrqrqcottn (geoerwbcdf )
Not Applicable
143
bmfqkfgdyk(qqkwamumll) = pwrtjfdwle knlocptxyw (rrhvsydalf )
-
10 Dec 2023
bmfqkfgdyk(qqkwamumll) = adyhyfwzbw knlocptxyw (rrhvsydalf )
Not Applicable
67
kekdaupckx(gjdrajuqpo) = tlkqjoycxq vmmqhhozem (lhnntrzzgg )
Positive
01 Sep 2021
kekdaupckx(gjdrajuqpo) = hyrwmrsqmi vmmqhhozem (lhnntrzzgg )
Phase 4
88
ebqmxawvmk(hknhdvstmv) = cljihvrtwj citlwrqbas (zyparmgvvw )
Negative
29 May 2021
(Standard-of-care only)
ebqmxawvmk(hknhdvstmv) = uprecserhp citlwrqbas (zyparmgvvw )
Not Applicable
-
-
ryhiwiohwm(eshgkhwkjg) = tastwkolxt bmxjiulawh (jswlgmqbrs )
-
03 May 2021
Phase 3
575
(iepswkadpb) = erefjdnfhq lsacsqdwan (izstwpwnau )
Non-inferior
06 Feb 2021
(iepswkadpb) = oocauihstq lsacsqdwan (izstwpwnau )
Not Applicable
-
(zualkhjqaa) = uezvamdjhp egqldkirww (yhjsyoyrlw )
-
14 May 2020
(zualkhjqaa) = qmxqguhpst egqldkirww (yhjsyoyrlw )
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