Collaborative Risk-stratified Investigation in Teen Inpatients With Critical Illness: Anticoagulation With LMWH in Kids for ThromboProphylaxis (CRITICAL-Kids-TP)

Critically ill adolescents are at greatest risk for developing hospital-acquired venous thromboembolism. To date, no phase 3 randomized controlled trials have been conducted for pharmacological thromboprophylaxis as primary venous thromboembolism prevention in children. The investigators will perform a United States definitive multicenter phase 3 randomized controlled trial of the low molecular weight heparin dalteparin as primary venous thromboembolism prophylaxis among critically ill adolescents who are classified a priori as high risk based upon the investigators validated risk prediction models.

Start Date31 Oct 2026

Sponsor / Collaborator

Johns Hopkins All Children's Hospital

[+1]

CTIS2025-521371-31-00

/ Not yet recruitingPhase 2IIT

PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial

Start Date01 Jan 2026

Sponsor / Collaborator

Assistance Publique Hopitaux De Paris

CTIS2023-509022-22-00

/ RecruitingPhase 3IIT

Antiplatelet therapy added to standard thromboprophylaxis to prevent thrombosis in pancreatic cancer patients - a randomized clinical trial (The PANART trial)

Start Date21 Aug 2025

Sponsor / Collaborator-

100 Clinical Results associated with Dalteparin Sodium

100 Translational Medicine associated with Dalteparin Sodium

100 Patents (Medical) associated with Dalteparin Sodium

1,293

Literatures (Medical) associated with Dalteparin Sodium

01 Mar 2026·JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The win ratio for evaluating edoxaban vs dalteparin for cancer-associated venous thromboembolism: an analysis of the randomized Hokusai Venous Thromboembolism Cancer trial

Article

Author: Sanfilippo, Kristen M ; Büller, Harry ; Lopes, Renato D ; Verhamme, Peter ; van Es, Nick ; Carrier, Marc ; Segers, Annelise ; Scheres, Luuk J J ; Redfors, Bjorn ; Weitz, Jeffrey I ; McIntyre, William F ; Bossuyt, Patrick M ; Di Nisio, Marcello ; Grosso, Michael ; Siegal, Deborah M

BACKGROUND:

The Hokusai Venous Thromboembolism (VTE) Cancer trial demonstrated that edoxaban was noninferior to dalteparin for the treatment of cancer-associated venous VTE.

OBJECTIVES:

We reanalyzed the trial using the win ratio, an approach that evaluates a composite of outcomes in a hierarchical order.

METHODS:

Forty-nine thrombosis experts ranked 10 outcomes in order of clinical importance from all-cause death (most important) to clinically relevant nonmajor bleeding (least important). We performed unmatched pairwise comparisons between participants on edoxaban and those on dalteparin at 6- and 12-month follow-up. Within each pair, edoxaban was assigned a win, loss, or tie according to the hierarchy of outcomes. We calculated the win ratio (total wins divided by total losses among edoxaban patients), with more wins than losses indicating the benefit of edoxaban, and the win difference (total wins minus total losses).

RESULTS:

Among 273 528 pairs (522 × 524 participants), edoxaban was associated with a win in 34.9%, a loss in 38.5%, and a tie in 26.6%. The win ratio was 0.91 (95% CI, 0.76-1.08), with a win difference of -3.55% (95% CI, -9.9% to 2.9%) at 12 months. The win ratio remained unchanged at 6 months (0.91; 95% CI, 0.75-1.11). The findings were consistent with a hierarchy of only death, recurrent VTE, and major bleeding (win ratio, 0.92; 95% CI, 0.76-1.11), or when replacing all-cause death with VTE-related death or fatal bleeding (win ratio, 0.83; 95% CI, 0.65-1.06).

CONCLUSION:

We observed no significant difference between edoxaban and dalteparin for the treatment of cancer-associated VTE when using the win ratio approach with a hierarchy of 10 prioritized outcomes.

22 Jan 2026·JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Piperazine-Based Quaternary Ammonium Macrocycle as a Universal Reversal Agent for Heparin Anticoagulants

Article

Author: Fang, Haodong ; Wang, Hui ; Zhang, Jiangshan ; Zhu, Yajie ; Zhang, Dan-Wei ; Zhou, Wei ; Dong, Xiaoyun ; Zhao, Gang ; Guo, Congying ; Zhang, Ru-Lei ; Gan, Shi-Xian ; Qi, Qiao-Yan ; Zhu, Haofeng ; Li, Zhan-Ting ; Yu, Shang-Bo

The development of a biocompatible antidote that can efficiently neutralize the anticoagulation activity of both unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) represents an unmet medical need. Here, we report that a piperazine-derived tetracationic macrocycle can efficiently neutralize both UFH and LMWHs, including dalteparin, enoxaparin, and nadroparin. In vitro and in vivo assays reveal that the compound outperforms protamine, exhibiting significantly improved neutralization activity, a broad therapeutic window for all heparins, and high biocompatibility, which is confirmed by its very low coagulation and hemolysis effect, as well as a high therapeutic index (20.5), defined as the ratio of the maximum tolerated dose to the effective therapeutic dose. Molecular dynamics simulations indicate that binding may occur through interlocked threading and direct contact patterns, which are stabilized by intermolecular hydrogen bonding and ion-pair electrostatic attraction.

01 Jan 2026·PEDIATRIC NEPHROLOGY

Overdose of low molecular weight heparin in an infant with stage 5 chronic kidney disease treated with hemofiltration

Article

Author: Watson, Liam ; O' Sullivan, Deirdre ; Shetty, Samikska ; Patel, Beejal ; Marlais, Matko ; Mathias, Mary

Low molecular weight heparin (LMWH) is widely used for the treatment and prevention of many venous thromboembolic disorders. LMWH acts through its ability to potentiate inhibition of factor Xa. LMWH undergoes primary renal excretion and therefore its elimination can be severely impacted by kidney disease. We report on the case of an infant with stage 5 chronic kidney disease (CKD) who received a prolonged accidental overdose of dalteparin. The infant was symptomatic with a falling haemoglobin, perinephric hematoma, and oozing venipuncture sites. Given the inability to predict drug clearance in this infant and her significant risk of bleeding, she underwent a successful trial of continuous veno-venous hemofiltration (CVVH) for the treatment of LMWH overdose. Whilst on CVVH, a steady downward trend in anti-Xa levels over 24 h was observed.

News (Medical) associated with Dalteparin Sodium

11 Feb 2025

·pipelinereview.com

Novartis bolsters late-stage cardiovascular pipeline with agreement to acquire Anthos Therapeutics for USD 925 million upfront

BASEL, Switzerland I February 11, 2025 I Novartis today announced that it has entered into an agreement to acquire Anthos Therapeutics, Inc., a Boston-based, privately held, clinical-stage biopharmaceutical company with abelacimab, a late-stage medicine in development for the prevention of stroke and systemic embolism in patients with atrial fibrillation. The transaction, which is subject to customary closing conditions, is fully in line with Novartis’ growth strategy and therapeutic area focus, leveraging the company’s strength and expertise in the cardiovascular area. Anthos Therapeutics, launched by Blackstone Life Sciences and Novartis in 2019, has advanced abelacimab through clinical development under a license from Novartis. Abelacimab is a novel, highly selective, fully human monoclonal antibody designed to induce effective hemostasis-sparing anticoagulation through Factor XI inhibition. Phase 2 data showed a significant reduction in bleeding events in patients taking abelacimab versus a standard of care direct-oral anticoagulant in patients with atrial fibrillation (AZALEA 1,2 ). Three Phase 3 clinical trials are ongoing for patients at risk of arterial and venous clots, one in patients with atrial fibrillation (LILAC-TIMI 76 3 ) and two in cancer associated thrombosis (ASTER 4 ) and (MAGNOLIA 5 ). “We are excited to join forces to advance the development of abelacimab, a potential first-in-class treatment and safer approach for stroke prevention in atrial fibrillation as well as cancer-associated thrombosis,” said Shreeram Aradhye, M.D., President, Development and Chief Medical Officer, Novartis. “Welcoming Anthos Therapeutics strengthens our focus in the cardiovascular space and complements our portfolio of life-changing treatments, comprehensive clinical programs, and strategic collaborations that help thousands of patients with heart disease around the world.” In July 2022 abelacimab received a Fast Track Designation from the FDA for the treatment of thrombosis associated with cancer. In September 2022 abelacimab was also granted a Fast Track Designation for the prevention of stroke and systemic embolism in patients with atrial fibrillation. “Abelacimab is a potential first-in-class medicine, which promises to be an effective and safer approach to preventing thrombosis and stroke than the current standards of care.” said David Soergel, M.D., Global Head, Cardiovascular, Renal and Metabolism Development Unit, Novartis. “We are proud that this medicine originated at Novartis and have been impressed with the Anthos Therapeutics team’s expertise and dedication and with the great progress they have made on the program. Now is the right time to bring abelacimab back into the Novartis CRM pipeline.” Transaction Details Under the terms of the agreement, Novartis will make an upfront payment of USD 925 million upon closing of the transaction, subject to certain customary adjustments, and potential additional payments of up to USD 2.15 billion upon achievement of specified regulatory and sales milestones. The transaction is expected to close in the first half of 2025, subject to satisfaction of customary closing conditions. About Abelacimab Abelacimab is a novel, investigational, highly selective, fully human monoclonal antibody that binds tightly to Factor XI to block its activation and prevent the generation of the activated form (Factor XIa). This mimics natural Factor XI deficiency, which is associated with protection from thromboembolic disease. About Novartis Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide. Reimagine medicine with us: Visit us at https://www.novartis.com and connect with us on LinkedIn , Facebook , X/Twitter and Instagram . References 1. Samer Al Said, et al. Bleeding with the FXI Inhibitor Abelacimab compared with Rivaroxaban in Patients on Antiplatelet therapy: A Prespecified Analysis of the AZALEA-TIMI 71 Trial. Available from: https://timi.org/wp-content/uploads/2024/11/Samer-Al-Said-Bleeding-with-the-FXI-Inhibitor-Abelacimab-compared-with-Rivaroxaban-in-Patients-on-Antiplatelet-therapy-A-Prespecified-Analysis-of-the-AZALEA-TIMI-71-Trial-.pdf . Accessed February 2024. 2. Ruff C, Patel S, et al. Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation. N Engl J Med. 2025; 392 (4):361-371.doi:10.1056/NEJMoa2406674 3. ClinicalTrials.gov . NCT05712200. Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76) (LILAC-TIMI 76). Available from: https://clinicaltrials.gov/study/NCT05712200?term=NCT05712200&rank=1 . Accessed February 2024. 4. ClinicalTrials.gov . NCT05171049. A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE. Available from: https://clinicaltrials.gov/study/NCT05171049 . Accessed February 2024. 5. ClinicalTrials.gov . NCT05171075. A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/ Genitourinary Cancer and Associated VTE (MAGNOLIA). Available from: https://clinicaltrials.gov/study/NCT05171075. Accessed February 2024 . SOURCE: Novartis

Clinical ResultFast TrackPhase 2Phase 3Acquisition

11 Feb 2025

·endpts.com

Novartis returns for its anticoagulant in up to $3.1B buy of Blackstone’s Anthos

Nearly six years to the day after offloading its factor XI inhibitor to Blackstone Life Sciences, Novartis is swooping up the monoclonal antibody for $925 million upfront and up to $3.1. billion total if certain regulatory and commercial milestones are met. The Wednesday move for Anthos Therapeutics’ abelacimab marks a key moment for multiple parties. The deal adds to the Swiss pharma giant’s late-stage cardiovascular pipeline with three Phase 3 trials underway. It brings another large pharma to the factor XI table, joining Bayer, the duo of Johnson & Johnson and Bristol Myers Squibb, and Regeneron, among others. It also lines up a successful exit for Blackstone Life Sciences just in time for it to pitch the story to investors: The alternative asset manager is currently fundraising another pool of capital to back late-stage clinical development companies, with a target that at a minimum matches its last fund of $5 billion. And for one individual, Bill Meury, it marks the second multibillion-dollar M&A exit in 14 months. Meury served as CEO of Karuna Therapeutics when Bristol Myers swarmed in with $14 billion to gain access to its schizophrenia medicine, which was subsequently approved. He joined Anthos as CEO last April and quickly brought in his right-hand man Will Kane — the former Karuna chief commercial officer — for the same role, plus the title of president. He had also tapped former Turnstone Biologics and Seagen executive Venkat Ramanan as chief financial officer. Novartis said it anticipates the deal will close before the second half of the year. It marks a potentially long sale process for the biotech, as Reuters reported in December 2023 that Blackstone was exploring an M&A exit for Anthos, according to unnamed sources. The “natural home for this has always been Novartis,” Nicholas Galakatos, Anthos chair and global leader of Blackstone Life Sciences, told Endpoints News on Wednesday morning. While “stroke prevention was not the highest priority” six years ago, it returned to favor, Galakatos said. Anthos means “flower” in Greek. “It blossomed and Novartis picked it,” he said. “We are proud that this medicine originated at Novartis and have been impressed with the Anthos Therapeutics team’s expertise and dedication and with the great progress they have made on the program,” David Soergel, who leads Novartis’ cardiovascular, renal and metabolism (CRM) drug development, said in a statement. “Now is the right time to bring abelacimab back into the Novartis CRM pipeline.” It follows another $3 billion deal from last week. Bain Capital said it would buy centuries-old Mitsubishi Tanabe Pharma to help boost the Japanese pharmaceutical industry. J&J , Eli Lilly and GSK also disclosed M&A moves during the JP Morgan Healthcare Conference. Aside from J&J’s $14 billion takeover of commercial drugmaker Intra-Cellular Therapies, all the deals have fallen into the tuck-in range that pharmas favored last year . While Anthos launched with $250 million from Blackstone, a behemoth with the firepower to provide additional capital, the biotech would likely eventually need a large pharma company to help it launch into a massive market that other top-tier drugmakers also seek to enter. Novartis, which had retained a minority stake in Anthos when it split ties with the antibody, has the capabilities of launching medicines worldwide and the wherewithal to finalize those three pivotal trials and regulatory interactions needed to get approval. Novo Holdings also held a minority stake. “With its deep roots in the cardiovascular space, Novartis is especially well positioned to advance abelacimab’s clinical development and bring this innovative product to healthcare providers and patients,” Meury said in a release. Anthos, Regeneron, Bayer and BMS-allied J&J are all developing forms of factor XI inhibitors, which seek to take advantage of genetic studies showing factor XI deficiency could reduce rates of myocardial infarction, stroke and other cardiovascular problems. For Anthos, the initial focus is on patients with atrial fibrillation and cancer-associated thrombosis. It has FDA fast track tags across both areas. All three Phase 3 trials are slated to wrap up in 2026, according to the federal clinical trial database. Blackstone said the trials should have data in the second half of 2026. The atrial fibrillation trial is comparing abelacimab to placebo on the rate of ischemic stroke or systemic embolism. It’s estimated to enroll 1,900 patients. Meanwhile, one of the late-stage cancer studies is comparing abelacimab to BMS and Pfizer’s factor Xa inhibitor Eliquis in 1,655 patients with cancer-associated venous thromboembolism (VTE). The other is testing Anthos’ candidate against the blood thinner dalteparin in 1,020 patients with gastrointestinal/genitourinary cancer-associated VTE. Editor’s note: This story was updated to include comments from Anthos chair Nicholas Galakatos.

Executive ChangePhase 3AcquisitionDrug Approval

08 Dec 2023

·synapse.patsnap.com

What are factor Xa inhibitors and how do you quickly get the latest development progress?

Factor Xa inhibitors are a class of anticoagulant drugs that work by inhibiting Factor Xa, a key enzyme in the coagulation cascade. The development of Factor Xa inhibitors began in the early 1980s, with the first inhibitor, antistasin, being isolated from the salivary glands of the Mexican leech Haementeria officinalis in 1987. Four drugs from this class are currently marketed worldwide. Rivaroxaban (Xarelto) was the first approved Factor Xa inhibitor, becoming commercially available in Europe and Canada in 2008. This was followed by the approval of apixaban (Eliquis) in Europe in 2011 and in the United States in 2012. Edoxaban (Lixiana, Savaysa) was approved in Japan in 2011 and in Europe and the US in 2015. The most recent addition to this class is betrixaban (Bevyxxa), which was approved in the US in 2017¹ Looking ahead, Factor Xa inhibitors are expected to continue to play a significant role in anticoagulant therapy. They are just as efficacious as low molecular weight heparin (LMWH) and warfarin but are given orally and don't need as strict monitoring. However, the emergence of resistance and the lack of an effective reversal drug when bleeding occurs are challenges that need to be addressed. Ongoing research and development efforts are focused on addressing these issues and expanding the clinical applications of Factor Xa inhibitors The analysis of target factor Xa in the pharmaceutical industry reveals a competitive landscape with multiple companies focusing on its development. Pfizer Inc., Bristol Myers Squibb Co., AstraZeneca PLC, Daiichi Sankyo Co., Ltd., and Bayer AG are among the companies growing the fastest under this target. The indications for drugs targeting factor Xa cover a wide range of cardiovascular and thrombotic conditions, indicating their potential in treating these diseases. Small molecule drugs, chemical drugs, and recombinant coagulation factors are progressing rapidly under this target. The European Union, the United States, and Japan are leading in terms of drug development, but China has also shown progress. Further analysis is required to understand the specific progress in China and its impact on the future development of target factor Xa. Overall, target factor Xa presents a promising opportunity in the pharmaceutical industry with a diverse range of companies, indications, drug types, and countries/locations involved in its development. The mechanism of action of factor Xa inhibitorsFactor Xa inhibitors are a type of medication that specifically target and inhibit the activity of factor Xa, which is a key enzyme involved in the blood clotting process. From a biomedical perspective, factor Xa is a crucial component of the coagulation cascade, a series of reactions that leads to the formation of blood clots. By inhibiting factor Xa, these medications prevent the formation of blood clots and reduce the risk of conditions such as deep vein thrombosis, pulmonary embolism, and stroke. Factor Xa inhibitors work by binding to factor Xa and blocking its ability to activate other clotting factors, ultimately preventing the formation of a stable blood clot. This mechanism of action makes them anticoagulant drugs, meaning they help to prevent the excessive formation of blood clots. These inhibitors are commonly used in the treatment and prevention of thromboembolic disorders, such as atrial fibrillation, venous thromboembolism, and post-operative prophylaxis. Examples of factor Xa inhibitors include rivaroxaban, apixaban, and edoxaban. It's important to note that factor Xa inhibitors carry a risk of bleeding, as they interfere with the normal clotting process. Therefore, their use should be carefully monitored, and patients may require regular blood tests to assess their coagulation status. Additionally, factor Xa inhibitors should be used with caution in individuals with certain medical conditions or those taking other medications that increase the risk of bleeding. Catalog of factor Xa InhibitorsThe currently marketed factor Xa inhibitors include: Andexanet alfaHuman Coagulation Factor X(Bio Products)ApixabanEdoxaban TosylateRivaroxabanArdeparin SodiumCertoparin sodiumParnaparin SodiumDanaparoid SodiumDalteparin SodiumFor more information, please click on the image below. What is the purpose of using factor Xa inhibitors?Factor Xa inhibitors that are used to prevent and treat thromboembolic disorders. For more information, please click on the image below to log in and search. How can I get the most recent advancements in factor Xa inhibitors?In the Synapse database, you can keep abreast of the latest research and development advances of factor Xa inhibitors anywhere and anytime, daily or weekly, through the "Set Alert" function. Click on the image below to embark on a brand new journey of drug discovery!

100 Deals associated with Dalteparin Sodium

External Link

KEGG	Wiki	ATC	Drug Bank
D03353	Dalteparin Sodium	B01AB04	DBSALT002488

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Angina, Unstable	United States	Pfizer Inc.	16 May 2019
Venous Thromboembolism	United States	Pfizer Inc.	16 May 2019
Myocardial Infarction	United States	Pfizer Inc.	10 Dec 2003
Coronary Artery Disease	China	Pfizer NV/SA	19 Mar 1999
Thrombosis	China	Pfizer NV/SA	19 Mar 1999
Venous Thrombosis	United States	Pfizer Inc.	22 Dec 1994
Disseminated Intravascular Coagulation	Japan	Pfizer Inc.	21 Jan 1992
Disseminated Intravascular Coagulation	Japan	Kissei Pharmaceutical Co., Ltd.	21 Jan 1992

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Kidney Failure, Chronic	Phase 3	Canada	Pfizer Inc.	01 Oct 2013
Peripheral arterial occlusive disease	Phase 3	Austria	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Belgium	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Canada	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Czechia	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Denmark	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Germany	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Greece	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Italy	Pfizer Inc.	01 Oct 2008
Peripheral arterial occlusive disease	Phase 3	Norway	Pfizer Inc.	01 Oct 2008

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03559114 (Pubmed \| BMJ Open)	Phase 3	Brain Injuries, Traumatic	348	Early dalteparin	pzjnzjmlgw(xdhsrfiyjk) = rnvowdfwyg iuofwlvvvd (nuzpeiadnw ) View more	Positive	01 Dec 2025
				Delayed dalteparin	wvnukqabsh(jmyvuukwqo) = kujuywswun xjggufvihj (gtblfikpqv ) View more
NCT04362085 (CTgov)	Phase 3	Post Acute COVID 19 Syndrome	465	Therapeutic Anticoagulation (Therapeutic Anticoagulation)	jlhvnujihd = isykjjqmjy rbmfujwrka (depshubkwg, qnnqyzbpmk - mvhihxtweh) View more	-	30 Jan 2025
				LMWH+fondaparinux+UFH (Standard Care)	jlhvnujihd = bzzykbegdo rbmfujwrka (depshubkwg, wckljeolxp - ocnmcwmrfc) View more
NCT02073682 (HOKUSAI VTE Cancer, Pubmed)	Phase 3	Thrombocytopenia \| Neoplasms platelet count ≤100 K/μL	-	Dalteparin	pqizeccxsk(thbxlucxme) = gyvmrggwmb rvkgkoniff (zewqzbbojp ) View more	Negative	01 Jun 2024
				Edoxaban	pqizeccxsk(thbxlucxme) = eefpsxzinz rvkgkoniff (zewqzbbojp ) View more
NCT02744092 (CANVAS, CTgov)	Not Applicable	Solid tumor \| Advanced Malignant Solid Neoplasm \| Pulmonary Embolism ... View more	811	rivaroxaban+Edoxaban+Apixaban+Dabigatran (Randomized Arm 1 (DOACs))	saavwuccjy = nrjrclmcpn dvjzxzojxw (ycsanwvjjz, ysjsqfqhlk - laxhgwehzf) View more	-	03 Oct 2023
				Warfarin+Fondaparinux+Enoxaparin+Dalteparin (Randomized Arm 2 (LMWH))	saavwuccjy = dcwlziqjyb dvjzxzojxw (ycsanwvjjz, vaycupzddb - wlociqqcik) View more
NCT02583191 \| NCT03139487 \| NCT02744092 \| NCT02746185 (Pubmed \| Mayo Clin Proc)	Phase 2/3	Thrombosis	2,894	Direct oral anticoagulants (DOACs)	lukspvipza(krdsalnyrh): P-Value = 1.34	Positive	01 Feb 2022
				Dalteparin
NCT03045406 (Caravaggio study, Pubmed \| J Thromb Haemost)	Phase 3	Neoplasms	-	Apixaban	bqjbnqbhjn(jerdwblmwy): HR = 1.43 (95% CI, 0.74 - 2.77) View more	-	01 Nov 2021
				Dalteparin
RIETECAT cohort study (ISTH2021)	Not Applicable	Venous Thromboembolism	-	Enoxaparin	zjqlnxafwg(zbcistlxvx) = tuxvlcmpps hfhoimfgpu (xryycznada ) View more	Positive	17 Jul 2021
				Tinzaparin or Dalteparin	zjqlnxafwg(zbcistlxvx) = mmakyteipg hfhoimfgpu (xryycznada ) View more
NCT00432796 (PERIOP2, Pubmed \| BMJ) Manual	Phase 3	Arterial embolism	1,471	dalteparin	rfwqibmkco(mysvmrdxge) = llufcnwdao fxoymunizw (fxobpzlbgs ) View more	Negative	09 Jun 2021
				Placebo	rfwqibmkco(mysvmrdxge) = nmbimvxzlw fxoymunizw (fxobpzlbgs ) View more
NCT00525057 (CTgov)	Not Applicable	Femoral Fractures \| Neoplasm Metastasis \| Multiple Myeloma ... View more	65	Dalteparin (Interventional (Dalteparin, Metastatic))	eugebkuhfv = zofqdyibhk lbwynjjusf (bgcarsgfuq, dyiqeoxaib - hdagfsgcyo) View more	-	22 Jan 2021
				Dalteparin (Interventional (Dalteparin, Sarcoma))	eugebkuhfv = vbfhoybumk lbwynjjusf (bgcarsgfuq, gknkfbwgtf - sjysdmhjai) View more
NCT02585713 (CTgov)	Phase 3	Thrombosis of cerebral veins \| Neoplasm Metastasis \| Pulmonary Embolism ... View more	300	Apixaban (Arm A (Apixaban))	vwrsoypnuw = sjvewrrxze bhhbtctxvt (ohfhosttbd, xxdzknvjkz - xdjrqgvhgz) View more	-	24 Dec 2019
				Dalteparin (Arm B (Dalteparin))	vwrsoypnuw = pcgcivooau bhhbtctxvt (ohfhosttbd, sbrvixczle - odktkozyni) View more

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