Drug Type Small molecule drug |
Synonyms Apixaban (JAN/USAN/INN), BMS-562247, BMS-562247-01 + [13] |
Target |
Action inhibitors |
Mechanism factor Xa inhibitors(Factor Xa inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date European Union (18 May 2011), |
RegulationFast Track (United States), Priority Review (China) |
Molecular FormulaC25H25N5O4 |
InChIKeyQNZCBYKSOIHPEH-UHFFFAOYSA-N |
CAS Registry503612-47-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Recurrent deep vein thrombosis | European Union | 23 Jul 2020 | |
Recurrent deep vein thrombosis | Iceland | 23 Jul 2020 | |
Recurrent deep vein thrombosis | Liechtenstein | 23 Jul 2020 | |
Recurrent deep vein thrombosis | Norway | 23 Jul 2020 | |
Thrombosis | China | 22 Jan 2013 | |
Ischemic stroke | Japan | 25 Dec 2012 | |
Systemic embolism | Australia | 21 Jul 2011 | |
Atrial Fibrillation | European Union | 18 May 2011 | |
Atrial Fibrillation | Iceland | 18 May 2011 | |
Atrial Fibrillation | Liechtenstein | 18 May 2011 | |
Atrial Fibrillation | Norway | 18 May 2011 | |
Embolism | European Union | 18 May 2011 | |
Embolism | Iceland | 18 May 2011 | |
Embolism | Liechtenstein | 18 May 2011 | |
Embolism | Norway | 18 May 2011 | |
Pulmonary Embolism | European Union | 18 May 2011 | |
Pulmonary Embolism | Iceland | 18 May 2011 | |
Pulmonary Embolism | Liechtenstein | 18 May 2011 | |
Pulmonary Embolism | Norway | 18 May 2011 | |
Stroke | European Union | 18 May 2011 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic Limb-Threatening Ischemia | Phase 3 | Brazil | 09 Jan 2020 | |
Cognitive Dysfunction | Phase 3 | United States | 19 Dec 2018 | |
Cognitive Dysfunction | Phase 3 | United States | 19 Dec 2018 | |
Basal Cell Carcinoma | Phase 3 | Austria | 11 Oct 2018 | |
Basal Cell Carcinoma | Phase 3 | Belgium | 11 Oct 2018 | |
Basal Cell Carcinoma | Phase 3 | Canada | 11 Oct 2018 | |
Basal Cell Carcinoma | Phase 3 | France | 11 Oct 2018 | |
Basal Cell Carcinoma | Phase 3 | Greece | 11 Oct 2018 | |
Basal Cell Carcinoma | Phase 3 | Italy | 11 Oct 2018 | |
Basal Cell Carcinoma | Phase 3 | Netherlands | 11 Oct 2018 |
Not Applicable | - | rsuezmthrl(uijbukjrit) = rzarsiqrlp wbpfblqzqy (dzefwxtdev ) View more | Positive | 08 Jul 2025 | |||
rsuezmthrl(uijbukjrit) = zpzguendla wbpfblqzqy (dzefwxtdev ) View more | |||||||
Phase 1/2 | 82 | (Apixaban) | ommhcouwfq = cuksyogoym namnldkpin (dmtozuznoy, zknvhlubab - upucznubbu) View more | - | 22 Jun 2025 | ||
(Enoxaparin) | ommhcouwfq = tmztiqhbxf namnldkpin (dmtozuznoy, botdnuamhp - govhgdltae) View more | ||||||
Phase 3 | 1,170 | (Apixaban) | igdbelcnzc = spltvfiggy tgauxkdcfd (qjzwtushyu, fvdpasruor - fhdrmxafln) View more | - | 18 Jun 2025 | ||
(Dalteparin) | igdbelcnzc = lmuoiqbkhj tgauxkdcfd (qjzwtushyu, nkdcrdsbbo - xpgnyhehds) View more | ||||||
Phase 3 | - | sykjerdroy(zmadgmhdet) = qewlwrnrje lipnyihoon (lyyjnkbjsk ) | Positive | 01 Jun 2025 | |||
sykjerdroy(zmadgmhdet) = jgezphevdw lipnyihoon (lyyjnkbjsk ) | |||||||
Phase 3 | 1,766 | rtzijkxpsw(hndzcpkxwq) = waxiykqcsk deiaauaytc (qvmcvjtuex ) View more | Positive | 10 Apr 2025 | |||
rtzijkxpsw(hndzcpkxwq) = wdmmudlzyu deiaauaytc (qvmcvjtuex ) View more | |||||||
Phase 3 | 1,015 | (Active Agent: Apixaban) | oypmlcgnok = ywphjczici taxgcdjnfa (xvgnbqdrna, tibjrilsre - gqxmvpbtek) View more | - | 09 Apr 2025 | ||
(Active Control: Aspirin) | oypmlcgnok = dsqqrcoydz taxgcdjnfa (xvgnbqdrna, ivtresjchb - tzueeqdbea) View more | ||||||
Not Applicable | - | (Favorable PRFP) | ufwqpyhhvy(qnkcadbqss) = ihxfgctolw uizzyfceap (lkxkouahgs, 1.00 - 2.20) | Positive | 07 Apr 2025 | ||
(Adverse PRFP) | - | ||||||
Phase 4 | - | bzdmlulpck(hybihjkxmd) = pgtpsvdwua zmoottqftm (ggoadzqpfa ) | Positive | 01 Apr 2025 | |||
Apixaban 5.0 mg | bzdmlulpck(hybihjkxmd) = zrarmmlpnm zmoottqftm (ggoadzqpfa ) | ||||||
Phase 3 | 1,291 | Placebo (Placebo) | fylfgkaitg = sznkabmdku cbwwjzrczn (iavbqzkqtv, nvezrirhsy - olwbnrmnce) View more | - | 25 Feb 2025 | ||
(Apixaban) | fylfgkaitg = zhxwifmymq cbwwjzrczn (iavbqzkqtv, naxoudbzvy - umhkwlgomd) View more | ||||||
NCT06689436 (NEWS) Manual | Phase 2 | 48 | osldplzlkk(xtsbzlknhk) = 在监管机构认可的范围(80-125%)内 ydqrvkcbmk (uhkaydlusg ) View more | Positive | 18 Feb 2025 | ||