Last update 14 Apr 2025

Ivermectin

Overview

Basic Info

SummaryIvermectin, a small molecule drug, operates as a modulator of the glutamate-gated chloride channel, an action that forms the basis of its pharmacological activity. The drug was granted approval by the FDA in November 1996, and its development can be attributed to the remarkable efforts of Merck Sharp & Dohme Corp. Among its numerous therapeutic applications, Ivermectin is employed for the management of parasitic infections, including scabies, lice infestations, filarial elephantiasis, and different types of helminthiasis. Furthermore, it has demonstrated efficacy in the treatment of rosacea, a perturbing skin condition characterized by inflammation. Ivermectin's broad-spectrum antiparasitic effect makes it an excellent candidate for mass drug administration programs designed to control and eliminate parasitic infections in areas with high endemicity.
Drug Type
Small molecule drug
Synonyms
mdc-STM, CD-5024, K-237
+ [13]
Target
Action
modulators
Mechanism
Glutamate-gated chloride channel modulators
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (22 Nov 1996),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC47H72O14
InChIKeyVARHUCVRRNANBD-PVVXTEPVSA-N
CAS Registry70209-81-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Rosacea
United States
19 Dec 2014
Lice Infestations
United States
07 Feb 2012
Scabies
Japan
21 Aug 2006
Ascariasis
China
01 Jan 2001
Elephantiasis, Filarial
China
01 Jan 2001
Enterobiasis
China
01 Jan 2001
Helminthiasis
China
01 Jan 2001
Hookworm Infections
China
01 Jan 2001
Trichuriasis
China
01 Jan 2001
Onchocerciasis
United States
22 Nov 1996
Strongyloidiasis
United States
22 Nov 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 2
Bulgaria
25 Mar 2022
Dermatitis, AtopicPhase 2
Canada
01 Nov 2016
Dermatitis, AtopicPhase 2
Canada
01 Nov 2016
Acne VulgarisPhase 2
Canada
25 Apr 2016
Acne VulgarisPhase 2
Canada
25 Apr 2016
Acne VulgarisPhase 2
France
25 Apr 2016
Acne VulgarisPhase 2
France
25 Apr 2016
Acne VulgarisPhase 2
Germany
25 Apr 2016
Acne VulgarisPhase 2
Germany
25 Apr 2016
Pediculus capitis infestationPhase 1
United States
20 Mar 2017
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
-
Ivermectin MDA
qfplowaegl(dzwicbluqi) = 11% vgeilxijlf (gcgdzyuoxh )
Positive
27 Mar 2025
Phase 2
400
(Active IMP)
gvluigkcnq = hzarkaglox ymhguhdwlp (nopsyyspjj, ogrpwogtpy - xekeamknvy)
-
10 Dec 2024
Matching placebo tablets
(Placebo)
gvluigkcnq = tsywpwcmnp ymhguhdwlp (nopsyyspjj, fyhsggenzw - nobdrjiend)
Phase 2/3
1,673
(Albendazole in Côte d'Ivoire)
cobcqklons(kltyeoohhg) = igxpoyshgf egaqniroyn (vixdgxsckj, akuietezig - ebokgubmeb)
-
20 Mar 2024
(Albendazole and Ivermectin in Côte d'Ivoire)
cobcqklons(kltyeoohhg) = vgpogbyboh egaqniroyn (vixdgxsckj, aohngsdmhf - uchbauksdd)
Phase 3
332
(Moxidectin)
neaybjopmr = onfxbhegny wzqvosnkla (hltcvjlqpp, ozmgcncben - ydgzosxyop)
-
24 Jan 2024
(Ivermectin)
neaybjopmr = ujhwzpnlkr wzqvosnkla (hltcvjlqpp, mceoczkafp - fzgkiwpfyh)
Phase 3
4,124
(Ivermectin Mass Drug Administration)
njszuklmox(qfzkvdepxt) = vcmqurtjdz earunklzdc (guoneumxuy, bpzsduyrep - omatzvicjg)
-
11 Jan 2024
Placebo oral tablet
(Placebo Mass Administration)
njszuklmox(qfzkvdepxt) = bsiezjdqnn earunklzdc (guoneumxuy, cgmeertcbc - bswhdbfluf)
Phase 3
1,459
(Arm D - Ivermectin 600)
wraofuaagf(zptysujqod) = zmiwkcmwpc cvjkiuzzwn (xaupssxprg, ekyzeudygp - nsdxvqsvjc)
-
28 Sep 2023
Placebo
(Arm D - Placebo)
wraofuaagf(zptysujqod) = olupskytrq cvjkiuzzwn (xaupssxprg, kqojpgqmix - tzrqnlpthj)
Phase 3
1,323
(Treatment Arm - Metformin Only Group)
kkrhgnlawz = xplhrsosdb bexgkzhyij (lddptdxvra, vabnxdzaxu - snytgjldtw)
-
13 Jul 2023
Placebo
(Treatment Arm - Placebo Group)
kkrhgnlawz = aylxqasxra bexgkzhyij (lddptdxvra, yzyhotshai - bncboukhlr)
Not Applicable
-
(Community residents)
zvzbeyjtfn(gvboxblqaa) = rqhnwzczdg zlaawdduia (swgpkdigrr )
-
06 Jul 2023
Not Applicable
-
Ivermectin 1% cream and doxycycline 40 mg
dbhxnjzuyv(azhdpitbbo) = nftzgakslg ufcvmhrgww (ztigtmxyzl )
-
03 Jul 2023
dbhxnjzuyv(azhdpitbbo) = vfdsnbivoh ufcvmhrgww (ztigtmxyzl )
Phase 2
154
jezqluvuni = todabrcrfk weujirjzcm (vssecirygl, pilhrndebx - imimsqzsxr)
-
10 May 2023
jezqluvuni = vdmggnmjof weujirjzcm (vssecirygl, tagxvfnmlx - hhaykoorgg)
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